E-Selectin Active Protein | SELE active protein

Human E-Selectin

Cat. Num. AAA691646

• Gene Names: SELE; ELAM; ESEL; CD62E; ELAM1; LECAM2
• Reactivity: Human
• Purity: > 95% by SDS-PAGE gel & HPLC analyses
• Synonyms: E-Selectin; Human E-Selectin; Endothelial leukocyte adhesion molecule 1; ELAM1; CD62E; SELE; SELE active protein

• Host: CHO Cells
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE gel & HPLC analyses
• Form/Format: Lyophilized
• Sequence: WSYNTSTEAM TYDEASAYCQ QRYTHLVAIQ NKEEIEYLNS ILSYSP SYYW IGIRKVNNVW VWVGTQKPLT EEAKNWAPGE PNNRQKDEDC V EIYIKREKD VGMWNDERCS KKKLALCYTA ACTNTSCSGH GECVETI NNY TCKCDPGFSG LKCEQIVNCT ALESPEHGSL VCSHPLGNFS YN SSCSISCD RGYLPSSMET MQCMSSGEWS APIPACNVVE CDAVTNPA NG FVECFQNPGS FPWNTTCTFD CEEGFELMGA QSLQCTSSGN WDN EKPTCKA VTCRAVRQPQ NGSVRCSHSP AGEFTFKSSC NFTCEEGFM L QGPAQVECTT QGQWTQQIPV CEAFQCTALS NPERGYMNCL PSAS GSFRYG SSCEFSCEQG FVLKGSKRLQ CGPTGEWDNE KPTCEAVRCD AVHQPPKGLV RCAHSPIGEF TYKSSCAFSC EEGFELHGST QLECT SQGQW TEEVPSCQVV KCSSLAVPGK INMSCSGEPV FGTVCKFACP EGWTLNGSAA RTCGATGHWS GLLPTCEAPT ESNIP
• Sequence Length: 610

• Biological Activity: Measured by its ability to support adhesion of U937 cells, a human hystiocytic lymphoma cell line.

Related Product Information for SELE active protein

Selectins are a family of calcium-dependent type 1 transmembrane proteins. Endothelial (E)-selectin is a heavily glycosylated transmembrane protein expressed by activated endothelial cells in microvascular linings. E-selectin, along with P-selectin and L-selectin, initiate recruitment of circulating leukocytes from blood to sites of inflammation in the vascular lining through interaction with specific cell surface associated carbohydrate determinants. E-selectin consists of an N-terminal type 1 lectin domain, an EGF-like domain, 6 sushi (CCP/SCR) domains, a transmembrane sequence, and a short cytoplasmic domain. Recombinant human E-selectin is a 58.6 kDa protein containing 535 amino acid residues, corresponding to the extracellular portion of the full length protein. Due to glycosylation, E-selectin migrates at an apparent molecular weight of approximately 65-85 kDa by SDS-PAGE analysis under reducing conditions.

Product Categories/Family for SELE active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 187960042
• NCBI GeneID: 6401
• NCBI Accession #: NP_000441.2
• NCBI GenBank Nucleotide #: NM_000450.2
• UniProt Accession #: P16581; P16111; A2RRD6
• Molecular Weight: 66,655 Da
• NCBI Official Full Name: E-selectin
• NCBI Official Synonym Full Names: selectin E
• NCBI Official Symbol: SELE
• NCBI Official Synonym Symbols: ELAM; ESEL; CD62E; ELAM1; LECAM2
• NCBI Protein Information: E-selectin; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2
• UniProt Protein Name: E-selectin
• Protein Family: E-selectin
• UniProt Gene Name: SELE
• UniProt Synonym Gene Names: ELAM1; ELAM-1; LECAM2
• UniProt Entry Name: LYAM2_HUMAN

NCBI Description

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Ref.1

Subunit structure: Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction. Ref.9 Ref.12

Subcellular location: Membrane; Single-pass type I membrane protein.

Polymorphism: A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

Sequence similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 6 Sushi (CCP/SCR) domains.