alpha6-Tubulin Phospho-Regulation Antibody Sampler Kit
alpha6-Tubulin Phospho-Regulation
Reactivity
Human, Rat, Mouse, Chicken
Applications
Western Blot, ELISA
Synonyms
alpha6-Tubulin Phospho-Regulation; TubulinaK; alpha6-Tubulin Phospho-Regulation antibody sampler kit
Reactivity
Human, Rat, Mouse, Chicken
Form/Format
Mouse monoclonal and rabbit polyclonal antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide. The secondary reagents are supplied in the same buffer without azide.
Applicable Applications for alpha6-Tubulin Phospho-Regulation antibody sampler kit
Western Blot (WB), ELISA (EIA)
Preparation and Storage
Store all at -20 degree C.Stable for 1 year.
Related Product Information for alpha6-Tubulin Phospho-Regulation antibody sampler kit
Kit Summary: The alpha-tubulin phospho-regulation kit can be used to examine phosphorylation of alpha-tubulin (Ser-165) relative to the totalexpression of alpha-tubulin. The kit includes rabbit polyclonal and mouse monoclonal antibodies to detect total alpha-tubulin, andsecondary reagents for rabbit polyclonal and mouse monoclonal antibody detection.
Background: Microtubules (MTs) are cytoskeletal elements that play an essential role in cell division and cytoplasmic organization.MTs are dynamic polymers of a/beta-Tubulin heterodimers. At least two populations of MTs, called dynamic and stableaccording to their rates of turnover, are readily distinguishable in cells. The proteins associated with MTs (MAPs) areamong the best-known factors that regulate MT dynamics and stability. In addition, a variety of different post-translationalmodifications may also regulate MT dynamics and stability. Phosphorylation is one of these modifications and it can occuron serine, threonine, and tyrosine residues in alpha- and beta-Tubulin isoforms. Multiple kinases can phosphorylate Ser-444 atthe C-terminus of betaIII-Tubulin in vitro, and unphosphorylated Ser-444 may be an early marker for cells of neuronallineage. Cdk1 can phosphorylate Ser-172 in beta-Tubulin during mitosis and this may impair tubulin incorporation into microtubules. In alpha-tubulin, PKC can phosphorylate Ser-165 leading to increased cell motility in human breast cells.
Background: Microtubules (MTs) are cytoskeletal elements that play an essential role in cell division and cytoplasmic organization.MTs are dynamic polymers of a/beta-Tubulin heterodimers. At least two populations of MTs, called dynamic and stableaccording to their rates of turnover, are readily distinguishable in cells. The proteins associated with MTs (MAPs) areamong the best-known factors that regulate MT dynamics and stability. In addition, a variety of different post-translationalmodifications may also regulate MT dynamics and stability. Phosphorylation is one of these modifications and it can occuron serine, threonine, and tyrosine residues in alpha- and beta-Tubulin isoforms. Multiple kinases can phosphorylate Ser-444 atthe C-terminus of betaIII-Tubulin in vitro, and unphosphorylated Ser-444 may be an early marker for cells of neuronallineage. Cdk1 can phosphorylate Ser-172 in beta-Tubulin during mitosis and this may impair tubulin incorporation into microtubules. In alpha-tubulin, PKC can phosphorylate Ser-165 leading to increased cell motility in human breast cells.
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Product Notes
The Human, Rat, Mouse, Chicken alpha6-Tubulin Phospho-Regulation (Catalog #AAA474613) is an Antibody Sampler Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA474613 Antibody Sampler Kit recognizes Human, Rat, Mouse, Chicken alpha6-Tubulin Phospho-Regulation. AAA Biotech's alpha6-Tubulin Phospho-Regulation can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the alpha6-Tubulin Phospho-Regulation for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "alpha6-Tubulin Phospho-Regulation, Antibody Sampler Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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