Chicken c-ros oncogene 1, receptor tyrosine kinase (ROS1) ELISA Kit | ROS1 elisa kit

Chicken c-ros oncogene 1, receptor tyrosine kinase (ROS1) ELISA Kit

Cat. Num. AAA7230557

• Gene Names: ROS1; ROS; MCF3; c-ros-1
• Reactivity: Chicken
• Synonyms: c-ros oncogene 1; receptor tyrosine kinase (ROS1); Chicken c-ros oncogene 1; receptor tyrosine kinase (ROS1) ELISA Kit; ROS1 elisa kit

• Reactivity: Chicken

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 187252527
• NCBI GeneID: 6098
• Molecular Weight: 263,915 Da
• NCBI Official Full Name: C-ros oncogene 1 , receptor tyrosine kinase
• NCBI Official Synonym Full Names: ROS proto-oncogene 1 , receptor tyrosine kinase
• NCBI Official Symbol: ROS1
• NCBI Official Synonym Symbols: ROS; MCF3; c-ros-1
• NCBI Protein Information: proto-oncogene tyrosine-protein kinase ROS; proto-oncogene c-Ros-1; c-ros oncogene 1 , receptor tyrosine kinase; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1
• UniProt Protein Name: Proto-oncogene tyrosine-protein kinase ROS
• Protein Family: Protein
• UniProt Gene Name: ROS1
• UniProt Synonym Gene Names: MCF3; ROS
• UniProt Entry Name: ROS1_HUMAN

NCBI Description

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

ROS: a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma.

Protein type: Oncoprotein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Sev family

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding

Biological Process: cell proliferation; peptidyl-tyrosine phosphorylation; spermatogenesis; cell differentiation; columnar/cuboidal epithelial cell development; cell growth; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of TOR signaling pathway