Follicle-Stimulating Hormone alpha/beta Dimer Recombinant Protein | CGA recombinant protein

Recombinant Human Follicle-Stimulating Hormone alpha/beta Dimer Protein

Cat. Num. AAA2552685

• Gene Names: CGA; HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Follicle-Stimulating Hormone alpha/beta Dimer; Recombinant Human Follicle-Stimulating Hormone alpha/beta Dimer Protein; Follicle-stimulating hormone; FSH; FSH alpha/beta; CGA recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Ala25-Ser116 & Asn19-Glu129
• Sequence Length: 116

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CGA recombinant protein

Human Follicle-stimulating hormone (FSH) is a member of glycoprotein hormones subunit beta family, whichalso includes LH, chorionic gonadotropin (CG) and thyroid-stimulating hormone (TSH). FSH and its familymembers are heterodimers consisting of non-covalently linked alpha- and beta-subunits. They share an identical alphasubunit, and beta-subunits vary. FSH has a unique beta-subunit (FSHbeta), which confers its specific biologic activityand is responsible for interaction with the FSH-receptor which belongs to a subfamily of GPCRs calledleucine-rich-repeat-containing GPCRs (LGRs). FSH is secreted from the pituitary gland and regulatesreproduction in mammals. FSH stimulates sertoli cell proliferation in testes and supports spermatogenesis inmales, and induces the maturation of ovarian follicles in females.

NCBI and Uniprot Product Information

• NCBI GI #: 4502787
• NCBI GeneID: 1081
• NCBI Accession #: NP_000726.1
• NCBI GenBank Nucleotide #: NM_000735.3
• UniProt Accession #: P01215; P01225
• Molecular Weight: Molecular Mass: 10.2; 12.5 kDa; Actual Protein Molecular Mass: 20 kDa
• NCBI Official Full Name: glycoprotein hormones alpha chain isoform 2
• NCBI Official Synonym Full Names: glycoprotein hormones, alpha polypeptide
• NCBI Official Symbol: CGA
• NCBI Official Synonym Symbols: HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA
• NCBI Protein Information: glycoprotein hormones alpha chain
• UniProt Protein Name: Glycoprotein hormones alpha chain
• Protein Family: Glycoprotein hormones
• UniProt Gene Name: CGA
• UniProt Synonym Gene Names: CG-alpha; FSH-alpha; LSH-alpha; TSH-alpha

NCBI Description

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.