Chorionic Gonadotropin/CGA Recombinant Protein | CGA recombinant protein

Chorionic Gonadotropin/CGA Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120569

• Gene Names: CGA; HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Chorionic Gonadotropin/CGA; Chorionic Gonadotropin/CGA Protein; Human; Recombinant (His Tag); Human FSH alpha/TSH alpha/CGA Protein (His Tag); CG-ALPHA Protein; FSH alpha Protein; FSHA Protein; GPHa Protein; GPHA1 Protein; HCG Protein; LHA Protein; TSHA Protein; glycoprotein hormones; alpha polypeptide; CGA recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ser116

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Ala 25
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human CGA (NP_000726.1)(Met1-Ser116) was expressed with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 4502787
• NCBI GeneID: 1081
• NCBI Accession #: NP_000726.1
• NCBI GenBank Nucleotide #: NM_000735.3
• UniProt Accession #: P01215
• Molecular Weight: 13,075 Da
• NCBI Official Full Name: glycoprotein hormones alpha chain isoform 2
• NCBI Official Synonym Full Names: glycoprotein hormones, alpha polypeptide
• NCBI Official Symbol: CGA
• NCBI Official Synonym Symbols: HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA
• NCBI Protein Information: glycoprotein hormones alpha chain; FSH-alpha; LSH-alpha; TSH-alpha; anterior pituitary glycoprotein hormones common subunit alpha; choriogonadotropin alpha chain; chorionic gonadotrophin subunit alpha; chorionic gonadotropin, alpha polypeptide; follicle-s
• UniProt Protein Name: Glycoprotein hormones alpha chain
• Protein Family: Glycoprotein hormones
• UniProt Gene Name: CGA
• UniProt Synonym Gene Names: CG-alpha; FSH-alpha; LSH-alpha; TSH-alpha
• UniProt Entry Name: GLHA_HUMAN

NCBI Description

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

CGA: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6q12-q21

Cellular Component: extracellular region

Molecular Function: protein binding; hormone activity

Biological Process: cellular protein metabolic process; cell-cell signaling; peptide hormone processing; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of cell migration