CD66b (CEACAM8) Recombinant Protein | CD66 recombinant protein
Human CD66b Recombinant (CEACAM8)
Purity
>95%, as determined by SDS-PAGE and HPLC
Synonyms
CD66b (CEACAM8); Human CD66b Recombinant (CEACAM8); Human CD66b Recombinant (CEACAM1) ; cd66b BGP; BGP1; BGPI; CEACAM8 cd66; CD66 recombinant protein
Host
HEk293 Cells
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Form/Format
Recombinant human CD66b (CEACAM-8) is supplied as a 0.2 um filtered PBS solution, pH7.2.
Sequence Length
349
Domain
Ig-like C2
Host Note
Optimized DNA sequence encoding extracellular domain of human CD66b including a C-terminal 6His tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant human CD66b (CEACAM8) is a monomer protein consisting of 405 amino acid residue subunits, due to glycosylation migrates as an approximately 65-85 kDa protein on SDS-PAGE.
Preparation and Storage
Recombinant human CD66b, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
Avoid repeated freeze/thaw cycles.
Related Product Information for CD66 recombinant protein
CEACAM6 (CD66c) and CEACAM8 (CD66b) are cell-adhesion proteins onneutrophils that belong to the human carcinoembryonic antigen (CEA) family. CEACAM6 reveals homophilic adhesion and heterophilic adhesionto other CEACAM family antigens including CEACAM8, CEACAM1, and CEA,whereas CEACAM8 exhibits only heterophilic adhesion to CEACAM6. ach CEACAM protein consists of several domains similar to theimmunoglobulin (Ig) V or C domains: one NH2- terminalIgV-like domain (N- domain) of 108 amino acids and zero to six IgC2- likedomains (A- and B- domains) followed by a glycolipid membrane anchor ora transmembrane-spanning region with a cytoplasmic tail. The N-domains of CEACAM familyproteins reveal sequence similarity with 70- 90% identity to eachother. CEA, CEACAM1, and CEACAM6 exhibit homophilic adhesion and heterophilic adhesion amongst them.Conversely, CEACAM8 binds only CEACAM6 relatively strongly comparedwith the binding activities of the other CEACAM members without showing homophilic-adhesion activity.
Product Categories/Family for CD66 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,154 Da
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 8
UniProt Protein Name
Carcinoembryonic antigen-related cell adhesion molecule 8
UniProt Gene Name
CEACAM8
UniProt Synonym Gene Names
CGM6
UniProt Entry Name
CEAM8_HUMAN
Uniprot Description
CEACAM8: Belongs to the immunoglobulin superfamily. CEA family.
Protein type: Immunoglobulin superfamily; Membrane protein, integral; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: extracellular space; integral to plasma membrane; plasma membrane
Biological Process: immune response; blood coagulation; leukocyte migration
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Product Notes
The CD66 ceacam8 (Catalog #AAA553242) is a Recombinant Protein produced from HEk293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CD66b (CEACAM8), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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