ZEB1 cdna clone
ZEB1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Uniprot Description
TCF8: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Interacts (via N-terminus) with SMARCA4/BRG1. Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Protein type: Transcription, coactivator/corepressor; C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10p11.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: cell proliferation; immune response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; regulation of transcription from RNA polymerase II promoter
Disease: Corneal Dystrophy, Fuchs Endothelial, 6; Corneal Dystrophy, Posterior Polymorphous, 3
Research Articles on ZEB1
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Product Notes
The ZEB1 zeb1 (Catalog #AAA1274884) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGGATG GCCCCAGGTG TAAGCGCAGA AAGCAGGCGA ACCCGCGGCG CAATAACGTT ACAAATTATA ATACTGTGGT AGAAACAAAT TCAGATTCAG ATGATGAAGA CAAACTGCAT ATTGTGGAAG AAGAAAGTGT TACAGATGCA GCTGACTGTG AAGGTGTACC AGAGGATGAC CTGCCAACAG ACCAGACAGT GTTACCAGGG AGGAGCAGTG AAAGAGAAGG GAATGCTAAG AACTGCTGGG AGGATGACAC AGGAAAGGAA GGGCAAGAAA TCCTGGGGCC TGAAGCTCAG GCAGATGAAG CAGGATGTAC AGTAAAAGAT GATGAATGCG AGTCAGATGC AGAAAATGAG CAAAACCATG ATCCTAATGT TGAAGAGTTT CTACAACAAC AAGACACTGC TGTCATTTTT CCTGAGGCAC CTGAAGAGGA CCAGAGGCAG GGCACACCAG AAGCCAGTGG TCATGATGAA AATGGAACAC CAGATGCATT TTCACAATTA CTCACCTGTC CATATTGTGA TAGAGGCTAT AAACGCTTTA CCTCTCTGAA AGAACACATT AAATATCGTC ATGAAAAGAA TGAAGATAAC TTTAGTTGCT CCCTGTGCAG TTACACCTTT GCATACAGAA CCCAACTTGA ACGTCACATG ACATCACATA AATCAGGAAG AGATCAAAGA CATGTGACGC AGTCTGGGTG TAATCGTAAA TTCAAATGCA CTGAGTGTGG AAAAGCTTTC AAATACAAAC ATCACCTAAA AGAGCACTTA AGAATTCACA GTGGAGAGAA GCCATATGAA TGCCCAAACT GCAAGAAACG CTTTTCCCAT TCTGGCTCCT ATAGCTCACA CATAAGCAGT AAGAAATGTA TCAGCTTGAT ACCTGTGAAT GGGCGACCAA GAACAGGACT CAAGACATCT CAGTGTTCTT CACCGTCTCT TTCAGCATCA CCAGGCAGTC CCACACGACC ACAGATACGG CAAAAGATAG AGAATAAACC CCTTCAAGAA CAACTTTCTG TTAACCAAAT TAAAACTGAA CCTGTGGATT ATGAATTCAA ACCCATAGTG GTTGCTTCAG GAATCAACTG TTCAACCCCT TTACAAAATG GGGTTTTCAC TGGTGGTGGC CCATTACAGG CAACCAGTTC TCCTCAGGGC ATGGTGCAAG CTGTTGTTCT GCCAACAGTT GGTTTGGTGT CTCCCATAAG TATCAATTTA AGTGATATTC AGAATGTACT TAAAGTGGCG GTAGATGGTA ATGTAATAAG GCAAGTGTTG GAGAATAATC AAGCCAATCT TGCATCCAAA GAACAAGAAA CAATCAATGC TTCACCCATA CAACAAGGTG GCCATTCTGT TATTTCAGCC ATCAGTCTTC CTTTGGTTGA TCAAGATGGA ACAACCAAAA TTATCATCAA CTACAGTCTT GAGCAGCCTA GCCAACTTCA AGTTGTTCCT CAAAATTTAA AAAAAGAAAA TCCAGTCGCT ACAAACAGTT GTAAAAGTGA AAAGTTACCA GAAGATCTTA CTGTTAAGTC TGAGAAGGAC AAAAGCTTTG AAGGGGGGGT GAATGATAGC ACTTGTCTTC TGTGTGATGA TTGTCCAGGA GATATTAATG CACTTCCAGA ATTAAAGCAC TATGACCTAA AGCAGCCTAC TCAGCCTCCT CCACTCCCTG CAGCAGAAGC TGAGAAGCCT GAGTCCTCTG TTTCATCAGC TACTGGAGAT GGCAATTTGT CTCCTAGTCA GCCACCTTTA AAGAACCTCT TGTCTCTCCT AAAAGCATAT TATGCTTTGA ATGCACAACC AAGTGCAGAA GAGCTCTCAA AAATTGCTGA TTCAGTAAAC CTACCACTGG ATGTAGTAAA AAAGTGGTTT GAAAAGATGC AAGCTGGACA GATTTCAGTG CAGTCTTCTG AACCATCTTC TCCTGAACCA GGCAAAGTAA ATATCCCTGC CAAGAACAAT GATCAGCCTC AATCTGCAAA TGCAAATGAA CCCCAGGACA GCACAGTAAA TCTACAAAGT CCTTTGAAGA TGACTAACTC CCCAGTTTTA CCAGTGGGAT CAACCACCAA TGGTTCCAGA AGTAGTACAC CATCCCCATC ACCTCTAAAC CTTTCCTCAT CCAGAAATAC ACAGGGTTAC TTGTACACAG CTGAGGGTGC ACAAGAAGAG CCACAAGTAG AACCTCTTGA TCTTTCACTA CCAAAGCAAC AGGGAGAATT ATTAGAAAGG TCAACTATCA CTAGTGTTTA CCAGAACAGT GTTTATTCTG TCCAGGAAGA ACCCTTGAAC TTGTCTTGCG CAAAAAAGGA GCCACAAAAG GACAGTTGTG TTACAGACTC AGAACCAGTT GTAAATGTAA TCCCACCAAG TGCCAACCCC ATAAATATCG CTATACCTAC AGTCACTGCC CAGTTACCCA CAATCGTGGC CATTGCTGAC CAGAACAGTG TTCCATGCTT AAGAGCGCTA GCTGCCAATA AGCAAACGAT TCTGATTCCC CAGGTGGCAT ACACCTACTC AACTACGGTC AGCCCTGCAG TCCAAGAACC ACCCTTGAAA GTGATCCAGC CAAATGGAAA TCAGGATGAA AGACAAGATA CTAGCTCAGA AGGAGTATCA AATGTAGAGG ATCAGAATGA CTCTGATTCT ACACCGCCCA AAAAGAAAAT GCGGAAGACA GAAAATGGAA TGTATGCTTG TGATTTGTGT GACAAGATAT TCCAAAAGAG TAGTTCATTA TTGAGACATA AATATGAACA CACAGGTAAA AGACCTCATG AGTGTGGAAT CTGTAAAAAG GCATTTAAAC ACAAACATCA TTTGATTGAA CACATGCGAT TACATTCTGG AGAAAAGCCC TATCAATGTG ACAAATGTGG AAAGCGCTTC TCACACTCTG GGTCTTATTC TCAACACATG AATCATCGCT ACTCCTACTG TAAGAGAGAA GCGGAAGAAC GTGACAGCAC AGAGCAGGAA GAGGCAGGGC CTGAAATCCT CTCGAATGAG CACGTGGGTG CCAGGGCGTC TCCCTCACAG GGCGACTCGG ACGAGAGAGA GAGTTTGACA AGGGAAGAGG ATGAAGACAG TGAAAAAGAG GAAGAGGAGG AGGATAAAGA GATGGAAGAA TTGCAGGAAG AAAAAGAATG TGAAAAACCA CAAGGGGATG AGGAAGAGGA GGAGGAGGAG GAAGAAGTGG AAGAAGAAGA GGTAGAAGAG GCAGAGAATG AGGGAGAAGA AGCAAAAACT GAAGGTCTGA TGAAGGATGA CAGGGCTGAA AGTCAAGCAA GCAGCTTAGG ACAAAAAGTA GGCGAGAGTA GTGAGCAAGT GTCTGAAGAA AAGACAAATG AAGCCTAA. It is sometimes possible for the material contained within the vial of "ZEB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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