WIPI2 cdna clone
WIPI2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]
Uniprot Description
WIPI2: Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. Interacts with TECPR1. Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. Belongs to the WD repeat SVP1 family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Autophagy
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: autophagic vacuole; cytoplasm; cytosol; extrinsic to membrane; membrane; nucleoplasm; pre-autophagosomal structure membrane; protein complex
Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding
Biological Process: autophagic vacuole formation; macroautophagy; mitochondrion degradation; protein amino acid lipidation
Research Articles on WIPI2
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Product Notes
The WIPI2 wipi2 (Catalog #AAA1267278) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaacctgg cgagccagag cggggaggcc ggcgccggcc agctgctctt cgccaacttc aaccaggaca acacgtccct agctgttggt agtaagtccg gttataaatt tttctccctt tcttctgtgg ataagctgga acagatctat gaatgcaccg atacggaaga tgtgtgcatt gtagagagat tgttctccag cagcctagtg gccatcgtga gccttaaagc accaaggaag ctaaaggttt gccactttaa gaagggaact gagatctgca actacagcta ctccaacacg attctggctg tgaagctcaa caggcagagg ctgatagtat gcctggagga gtccctgtac atccacaaca ttcgggacat gaaggtgctg catacgatca gggagacgcc tccaaaccct gcaggcctgt gtgcgctgtc aatcaacaac gacaactgct acttggcgta cccagggagc gcgaccatcg gagaggtgca ggtcttcgat accattaatt tgagagctgc aaacatgatt ccggctcacg acagtccttt agcggcactg gcctttgacg caagtggaac taaacttgcc acggcttcgg agaaggggac cgtgattagg gtattttcca ttccagaagg acaaaaactc tttgagtttc ggagaggagt aaagaggtgc gtgagcatct gctccctggc cttcagcatg gacggcatgt tcctctccgc ctccagcaac actgagaccg tgcacatctt caaactcgag actgtgaaag aaaaaccccc agaggagccc accacctgga ccgggtactt cgggaaagtg ctcatggcct ccaccagcta cctgccttcc caagtgacag aaatgttcaa ccagggcaga gccttcgcca cggtccgcct gccattctgc ggccacaaaa acatctgctc gctagccaca attcagaaga tcccgcggtt gttggtgggt gccgccgacg ggtacctgta catgtacaac ctggaccccc aggagggcgg cgagtgtgcc ctgatgaagc agcaccggct ggacggcagt ctggaaacga ccaatgagat cttggactct gcctctcacg actgcccctt agtcactcag acatacggcg cagctgcagg aaaaggtact tacgtgcctt catccccaac gagacttgcc tacacagacg acctgggtgc tgtgggtggc gcctgcctgg aggacgaggc cagcgccctg cgcctggatg aggacagcga gcacccgccc atgattcttc ggactgactg a. It is sometimes possible for the material contained within the vial of "WIPI2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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