WHSC1L1 cdna clone

WHSC1L1 cDNA Clone

Gene Names

WHSC1L1; NSD3; WHISTLE; pp14328

Synonyms

WHSC1L1; WHSC1L1 cDNA Clone; WHSC1L1 cdna clone

Ordering
Cat. Num. AAA1269277 For Research Use Only!

Sequence

ATGGATTTCTCTTTCTCTTTCATGCAAGGGATCATGGGAAACACAATTCAGCAACCACCTCAACTCATTGACTCCGCCAACATCCGTCAGGAGGATGCCTTTGATAACAACAGTGACATTGCTGAAGATGGTGGCCAGACACCATATGAAGCTACTTTGCAGCAAGGCTTTCAGTACCCAGCTACAACAGAAGATCTTCCTCCACTCACAAATGGGTATCCATCATCAATCAGTGTGTATGAAACTCAAACCAAATACCAGTCATATAATCAGTATCCTAATGGGTCAGCCAATGGCTTTGGTGCAGTTAGAAACTTTAGCCCCACTGACTATTATCATTCAGAAATTCCAAACACAAGACCACATGAAATTCTGGAAAAACCTTCCCCTCCACAGCCACCACCTCCTCCTTCGGTACCACAAACTGTGATTCCAAAGAAGACTGGCTCACCTGAAATTAAACTAAAAATAACCAAAACTATCCAGAATGGCAGGGAATTGTTTGAGTCTTCCCTTTGTGGAGACCTTTTAAATGAAGTACAGGCAAGTGAGCACACGAAATCAAAGCATGAAAGCAGAAAAGAAAAGAGGAAAAAAAGCAACAAGCATGACTCATCAAGATCTGAAGAGCGCAAGTCACACAAAATCCCCAAATTAGAACCAGAGGAACAAAATAGACCAAATGAGAGGGTTGACACTGTATCAGAAAAACCAAGGGAAGAACCAGTACTAAAAGAGGAAGCCCCAGTTCAGCCAATACTATCTTCTGTTCCAACAACGGAAGTGTCCACTGGTGTTAAGTTTCAGGTTGGCGATCTTGTGTGGTCCAAGGTGGGAACCTATCCTTGGTGGCCTTGTATGGTTTCAAGTGATCCCCAGCTTGAGGTTCATACTAAAATTAACACAAGAGGTGCCCGAGAATATCATGTCCAGTTTTTTAGCAACCAGCCAGAGAGGGCGTGGGTTCATGAAAAACGGGTACGAGAGTATAAAGGTCATAAACAGTATGAAGAATTACTGGCTGAGGCAACCAAACAAGCCAGCAATCACTCTGAGAAACAAAAGATTCGGAAACCCCGACCTCAGAGAGAACGTGCTCAGTGGGATATTGGCATTGCCCATGCAGAGAAAGCATTGAAAATGACTCGAGAAGAAAGAATAGAACAGTATACTTTTATTTACATTGATAAACAGCCTGAAGAGGCTTTATCCCAAGCAAAAAAGAGTGTTGCCTCCAAAACCGAAGTTAAAAAAACCCGACGACCAAGATCTGTGCTGAATACTCAGCCAGAACAGACCAATGCAGGGGAGGTGGCCTCCTCACTCTCAAGTACTGAAATTCGGAGACATAGCCAGAGGCGGCACACAAGTGCGGAAGAGGAAGAGCCACCGCCTGTTAAAATAGCCTGGAAAACTGCGGCAGCAAGGAAATCCTTACCAGCTTCCATTACGATGCACAAAGGGAGCCTGGATTTGCAGAAGTGTAACATGTCTCCAGTTGTGAAAATTGAACAAGTGTTTGCTCTTCAGAATGCTACAGGGGATGGGAAATTTATCGATCAATTTGTTTATTCAACAAAGGGAATTGGTAACAAAACAGAAATAAGTGTCAGGGGGCAAGACAGGCTTATAATTTCTACACCAAACCAGAGAAATGAAAAGCCAACGCAGAGTGTATCATCTCCTGAAGCAACATCTGGTTCTACAGGCTCAGTAGAAAAGAAGCAACAGAGAAGATCAATTAGAACTCGTTCTGAATCAGAGAAATCCACTGAGGTTGTGCCAAAGAAGAAGATCAAAAAGGAGCAGGTTGAAACAGTTCCTCAGGCTACAGTGAAGACTGGATTACAGAAAGGTGCCAGCGAGATTTCAGATTCCTGTAAACCTCTAAAGAAAAGGAGTCGCGCCTCAACTGATGTAGAAATGACTAGTTCAGCATACAGAGACACATCTGACTCCGATTCTAGAGGACTGAGTGACCTGCAGGTAGGCTTTGGAAAGCAAGTAGATAGCCCTTCAGCTACTGCAGATGCAGACGTTTCTGATGTGCAGTCCATGGATTCAAGTTTGTCGAGAAGAGGCACTGGAATGAGTAAGAAGGACACTGTATGTCAGATTTGTGAAAGCTCTGGTGACTCTCTGATTCCTTGTGAGGGAGAGTGCTGCAAACACTTTCACCTGGAGTGCCTGGGATTGGCATCACTTCCTGATAGCAAGTTCATCTGCATGGAATGTAAAACTGGGCAGCACCCATGTTTTTCGTGTAAAGTGTCTGGTAAAGATGTGAAGCGTTGTTCTGTTGGTGCTTGTGGGAAATTTTATCATGAAGCCTGTGTCCGCAAATTCCCCACTGCCATCTTTGAATCAAAAGGATTCCGCTGTCCTCAGCACTGCTGCTCTGCCTGCTCTATGGAGAAAGATATCCACAAAGCAAGTAAAGGCCGCATGATGAGATGTTTAAGATGTCCAGTTGCCTATCACTCTGGAGATGCTTGCATTGCGGCCGGAAGCATGTTAGTATCCTCCTACATTCTCATCTGTAGTAATCATTCCAAACGGAGCAGTAATTCTTCTGCTGTAAATGTAGGCTTTTGTTTCGTTTGTGCCAGAGGGCTGATAGTTCAGGACCATTCAGACCCCATGTTCAGTTCATATGCCTATAAGTCCCACTACCTACTGAATGAATCAAATCGTGCTGAGTTGATGAAATTACCTATGATTCCTTCTTCGTCAGCTTCCAAAAAGAAATGTGAGAAAGGTGGAAGATTGCTCTGCTGTGAATCGTGCCCAGCTTCCTTCCACCCGGAATGCCTAAGCATAGAAATGCCAGAAGGCTGCTGGAATTGTAATGACTGTAAAGCTGGCAAGAAACTACATTACAAGCAGATTGTTTGGGTCAAATTGGGAAATTACAGATGGTGGCCAGCAGAGATCTGCAACCCCAGGTCTGTGCCACTGAACATCCAGGGCCTTAAACATGACTTGGGGGACTTCCCTGTATTCTTCTTTGGTTCTCATGACTACTACTGGGTACACCAGGGCAGAGTGTTCCCTTATGTTGAAGGAGACAAAAGCTTTGCTGAAGGGCAGACTAGTATTAACAAGACCTTCAAAAAGGCACTGGAAGAAGCTGCAAAACGTTTCCAGGAATTGAAAGCACAAAGAGAAAGTAAAGAAGCCCTAGAGATTGAAAAAAACTCAAGAAAACCCCCTCCCTACAAACACATCAAAGCTAACAAAGTAATAGGAAAGGTGCAGATCCAGGTTGCTGACCTGTCAGAGATTCCCCGCTGTAACTGCAAGCCAGCTGATGAAAACCCTTGTGGCTTGGAATCGGAGTGCCTGAACAGAATGTTGCAGTATGAATGCCACCCGCAGGTGTGCCCAGCTGGAGATCGTTGTCAGAACCAGTGCTTTACAAAGAGACTATACCCTGATGCAGAGATCATCAAAACGGAGCGGAGAGGCTGGGGCCTCAGGACCAAAAGGAGCATTAAGAAGGGTGAATTTGTAAATGAATACGTCGGTGAATTAATTGATGAAGAAGAATGCAGATTGCGAATCAAGCGAGCCCACGAGAACAGTGTAACTAATTTTTATATGTTAACTGTTACCAAGGACCGTATAATTGATGCCGGCCCAAAAGGAAATTATTCTCGCTTCATGAACCACAGTTGTAATCCCAACTGTGAAACACAAAAGTGGACAGTGAATGGAGATGTTCGAGTGGGACTATTTGCTCTCTGTGATATTCCTGCAGGGATGGAGTTAACATTTAATTATAACCTAGATTGTCTGGGCAACGGCAGAACGGAGTGCCACTGTGGAGCAGATAACTGCAGTGGTTTTCTAGGAGTGCGGCCAAAGTCGGCATGTGCGTCAACAAATGAAGAGAAGGCAAAAAATGCTAAGTTAAAACAGAAGAGACGAAAGATCAAAACAGAACCAAAGCAGATGCATGAAGATTACTGTTTTCAATGTGGAGATGGTGGAGAGCTGGTCATGTGTGACAAAAAAGACTGTCCCAAAGCATACCACCTCCTATGCCTTAACCTGACTCAGCCACCATATGGAAAGTGGGAGTGTCCGTGGCATCAGTGCGATGAGTGCAGCAGTGCAGCTGTTTCCTTCTGTGAATTCTGTCCACATTCATTTTGTAAAGATCATGAAAAGGGGGCCCTGGTTCCCTCTGCACTGGAAGGCCGCCTCTGCTGCTCGGAACATGACCCCATGGCTCCTGTGTCACCAGAATACTGGAGCAAGATAAAATGTAAATGGGAATCACAAGATCATGGAGAAGAAGTAAAAGAATAA

Sequence Length

4314

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

109731703

NCBI GeneID

54904

Molecular Weight

160,314 Da

NCBI Official Full Name

Homo sapiens Wolf-Hirschhorn syndrome candidate 1-like 1, mRNA

NCBI Official Synonym Full Names

Wolf-Hirschhorn syndrome candidate 1-like 1

NCBI Official Symbol

WHSC1L1

NCBI Official Synonym Symbols

NSD3; WHISTLE; pp14328

NCBI Protein Information

histone-lysine N-methyltransferase NSD3

UniProt Protein Name

Histone-lysine N-methyltransferase NSD3

Protein Family

Histone-lysine N-methyltransferase

UniProt Gene Name

WHSC1L1

UniProt Synonym Gene Names

NSD3; WHSC1-like protein 1

UniProt Entry Name

NSD3_HUMAN

NCBI Description

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]

Uniprot Description

WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.

Protein type: Histone-binding; Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; Oncoprotein; EC 2.1.1.43; Methyltransferase

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone-lysine N-methyltransferase activity; protein binding

Biological Process: histone methylation

Disease: Leukemia, Acute Myeloid

Research Articles on WHSC1L1

1. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

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Product Notes

The WHSC1L1 whsc1l1 (Catalog #AAA1269277) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGATTTCT CTTTCTCTTT CATGCAAGGG ATCATGGGAA ACACAATTCA GCAACCACCT CAACTCATTG ACTCCGCCAA CATCCGTCAG GAGGATGCCT TTGATAACAA CAGTGACATT GCTGAAGATG GTGGCCAGAC ACCATATGAA GCTACTTTGC AGCAAGGCTT TCAGTACCCA GCTACAACAG AAGATCTTCC TCCACTCACA AATGGGTATC CATCATCAAT CAGTGTGTAT GAAACTCAAA CCAAATACCA GTCATATAAT CAGTATCCTA ATGGGTCAGC CAATGGCTTT GGTGCAGTTA GAAACTTTAG CCCCACTGAC TATTATCATT CAGAAATTCC AAACACAAGA CCACATGAAA TTCTGGAAAA ACCTTCCCCT CCACAGCCAC CACCTCCTCC TTCGGTACCA CAAACTGTGA TTCCAAAGAA GACTGGCTCA CCTGAAATTA AACTAAAAAT AACCAAAACT ATCCAGAATG GCAGGGAATT GTTTGAGTCT TCCCTTTGTG GAGACCTTTT AAATGAAGTA CAGGCAAGTG AGCACACGAA ATCAAAGCAT GAAAGCAGAA AAGAAAAGAG GAAAAAAAGC AACAAGCATG ACTCATCAAG ATCTGAAGAG CGCAAGTCAC ACAAAATCCC CAAATTAGAA CCAGAGGAAC AAAATAGACC AAATGAGAGG GTTGACACTG TATCAGAAAA ACCAAGGGAA GAACCAGTAC TAAAAGAGGA AGCCCCAGTT CAGCCAATAC TATCTTCTGT TCCAACAACG GAAGTGTCCA CTGGTGTTAA GTTTCAGGTT GGCGATCTTG TGTGGTCCAA GGTGGGAACC TATCCTTGGT GGCCTTGTAT GGTTTCAAGT GATCCCCAGC TTGAGGTTCA TACTAAAATT AACACAAGAG GTGCCCGAGA ATATCATGTC CAGTTTTTTA GCAACCAGCC AGAGAGGGCG TGGGTTCATG AAAAACGGGT ACGAGAGTAT AAAGGTCATA AACAGTATGA AGAATTACTG GCTGAGGCAA CCAAACAAGC CAGCAATCAC TCTGAGAAAC AAAAGATTCG GAAACCCCGA CCTCAGAGAG AACGTGCTCA GTGGGATATT GGCATTGCCC ATGCAGAGAA AGCATTGAAA ATGACTCGAG AAGAAAGAAT AGAACAGTAT ACTTTTATTT ACATTGATAA ACAGCCTGAA GAGGCTTTAT CCCAAGCAAA AAAGAGTGTT GCCTCCAAAA CCGAAGTTAA AAAAACCCGA CGACCAAGAT CTGTGCTGAA TACTCAGCCA GAACAGACCA ATGCAGGGGA GGTGGCCTCC TCACTCTCAA GTACTGAAAT TCGGAGACAT AGCCAGAGGC GGCACACAAG TGCGGAAGAG GAAGAGCCAC CGCCTGTTAA AATAGCCTGG AAAACTGCGG CAGCAAGGAA ATCCTTACCA GCTTCCATTA CGATGCACAA AGGGAGCCTG GATTTGCAGA AGTGTAACAT GTCTCCAGTT GTGAAAATTG AACAAGTGTT TGCTCTTCAG AATGCTACAG GGGATGGGAA ATTTATCGAT CAATTTGTTT ATTCAACAAA GGGAATTGGT AACAAAACAG AAATAAGTGT CAGGGGGCAA GACAGGCTTA TAATTTCTAC ACCAAACCAG AGAAATGAAA AGCCAACGCA GAGTGTATCA TCTCCTGAAG CAACATCTGG TTCTACAGGC TCAGTAGAAA AGAAGCAACA GAGAAGATCA ATTAGAACTC GTTCTGAATC AGAGAAATCC ACTGAGGTTG TGCCAAAGAA GAAGATCAAA AAGGAGCAGG TTGAAACAGT TCCTCAGGCT ACAGTGAAGA CTGGATTACA GAAAGGTGCC AGCGAGATTT CAGATTCCTG TAAACCTCTA AAGAAAAGGA GTCGCGCCTC AACTGATGTA GAAATGACTA GTTCAGCATA CAGAGACACA TCTGACTCCG ATTCTAGAGG ACTGAGTGAC CTGCAGGTAG GCTTTGGAAA GCAAGTAGAT AGCCCTTCAG CTACTGCAGA TGCAGACGTT TCTGATGTGC AGTCCATGGA TTCAAGTTTG TCGAGAAGAG GCACTGGAAT GAGTAAGAAG GACACTGTAT GTCAGATTTG TGAAAGCTCT GGTGACTCTC TGATTCCTTG TGAGGGAGAG TGCTGCAAAC ACTTTCACCT GGAGTGCCTG GGATTGGCAT CACTTCCTGA TAGCAAGTTC ATCTGCATGG AATGTAAAAC TGGGCAGCAC CCATGTTTTT CGTGTAAAGT GTCTGGTAAA GATGTGAAGC GTTGTTCTGT TGGTGCTTGT GGGAAATTTT ATCATGAAGC CTGTGTCCGC AAATTCCCCA CTGCCATCTT TGAATCAAAA GGATTCCGCT GTCCTCAGCA CTGCTGCTCT GCCTGCTCTA TGGAGAAAGA TATCCACAAA GCAAGTAAAG GCCGCATGAT GAGATGTTTA AGATGTCCAG TTGCCTATCA CTCTGGAGAT GCTTGCATTG CGGCCGGAAG CATGTTAGTA TCCTCCTACA TTCTCATCTG TAGTAATCAT TCCAAACGGA GCAGTAATTC TTCTGCTGTA AATGTAGGCT TTTGTTTCGT TTGTGCCAGA GGGCTGATAG TTCAGGACCA TTCAGACCCC ATGTTCAGTT CATATGCCTA TAAGTCCCAC TACCTACTGA ATGAATCAAA TCGTGCTGAG TTGATGAAAT TACCTATGAT TCCTTCTTCG TCAGCTTCCA AAAAGAAATG TGAGAAAGGT GGAAGATTGC TCTGCTGTGA ATCGTGCCCA GCTTCCTTCC ACCCGGAATG CCTAAGCATA GAAATGCCAG AAGGCTGCTG GAATTGTAAT GACTGTAAAG CTGGCAAGAA ACTACATTAC AAGCAGATTG TTTGGGTCAA ATTGGGAAAT TACAGATGGT GGCCAGCAGA GATCTGCAAC CCCAGGTCTG TGCCACTGAA CATCCAGGGC CTTAAACATG ACTTGGGGGA CTTCCCTGTA TTCTTCTTTG GTTCTCATGA CTACTACTGG GTACACCAGG GCAGAGTGTT CCCTTATGTT GAAGGAGACA AAAGCTTTGC TGAAGGGCAG ACTAGTATTA ACAAGACCTT CAAAAAGGCA CTGGAAGAAG CTGCAAAACG TTTCCAGGAA TTGAAAGCAC AAAGAGAAAG TAAAGAAGCC CTAGAGATTG AAAAAAACTC AAGAAAACCC CCTCCCTACA AACACATCAA AGCTAACAAA GTAATAGGAA AGGTGCAGAT CCAGGTTGCT GACCTGTCAG AGATTCCCCG CTGTAACTGC AAGCCAGCTG ATGAAAACCC TTGTGGCTTG GAATCGGAGT GCCTGAACAG AATGTTGCAG TATGAATGCC ACCCGCAGGT GTGCCCAGCT GGAGATCGTT GTCAGAACCA GTGCTTTACA AAGAGACTAT ACCCTGATGC AGAGATCATC AAAACGGAGC GGAGAGGCTG GGGCCTCAGG ACCAAAAGGA GCATTAAGAA GGGTGAATTT GTAAATGAAT ACGTCGGTGA ATTAATTGAT GAAGAAGAAT GCAGATTGCG AATCAAGCGA GCCCACGAGA ACAGTGTAAC TAATTTTTAT ATGTTAACTG TTACCAAGGA CCGTATAATT GATGCCGGCC CAAAAGGAAA TTATTCTCGC TTCATGAACC ACAGTTGTAA TCCCAACTGT GAAACACAAA AGTGGACAGT GAATGGAGAT GTTCGAGTGG GACTATTTGC TCTCTGTGAT ATTCCTGCAG GGATGGAGTT AACATTTAAT TATAACCTAG ATTGTCTGGG CAACGGCAGA ACGGAGTGCC ACTGTGGAGC AGATAACTGC AGTGGTTTTC TAGGAGTGCG GCCAAAGTCG GCATGTGCGT CAACAAATGA AGAGAAGGCA AAAAATGCTA AGTTAAAACA GAAGAGACGA AAGATCAAAA CAGAACCAAA GCAGATGCAT GAAGATTACT GTTTTCAATG TGGAGATGGT GGAGAGCTGG TCATGTGTGA CAAAAAAGAC TGTCCCAAAG CATACCACCT CCTATGCCTT AACCTGACTC AGCCACCATA TGGAAAGTGG GAGTGTCCGT GGCATCAGTG CGATGAGTGC AGCAGTGCAG CTGTTTCCTT CTGTGAATTC TGTCCACATT CATTTTGTAA AGATCATGAA AAGGGGGCCC TGGTTCCCTC TGCACTGGAA GGCCGCCTCT GCTGCTCGGA ACATGACCCC ATGGCTCCTG TGTCACCAGA ATACTGGAGC AAGATAAAAT GTAAATGGGA ATCACAAGAT CATGGAGAAG AAGTAAAAGA ATAA. It is sometimes possible for the material contained within the vial of "WHSC1L1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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WHSC1L1 cdna clone