UPP1 cdna clone
UPP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
Uniprot Description
UPP1: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.4.2.3; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 7p12.3
Cellular Component: cytosol
Molecular Function: uridine phosphorylase activity
Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage
Research Articles on UPP1
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Product Notes
The UPP1 upp1 (Catalog #AAA1269821) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcagagaa agctgaaagt cacaagtctg gagcccggca ctgtggtcat aacagagcag gcagtggata cctgcttcaa ggcagagttt gagcagattg tcctggggaa gcgggtcatc cggaaaacgg accttaacaa gaagctggtg caggagctgt tgctgtgttc tgcagagctg agcgagttca ccacagtggt ggggaacacc atgtgcacct tggacttcta tgaagggcaa ggccgtctgg atggggctct ctgctcctac acggagaagg acaagcaggc gtatctggag gcagcctatg cagccggcgt ccgcaatatc gagatggagt cctcggtgtt tgccgccatg tgcagcgcct gcggcctcca agcggccgtg gtgtgtgtca ccctcctgaa ccgcctggaa ggggaccaga tcagcagccc tcgcaatgtg ctcagcgagt accagcagag gccgcagcgg ctggtgagct acttcatcaa gaagaaactg agcaaggcct ga. It is sometimes possible for the material contained within the vial of "UPP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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