UBE2E3 cdna clone
UBE2E3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Description
UBE2E3: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 2q32.1
Molecular Function: protein binding; ubiquitin-protein ligase activity
Research Articles on UBE2E3
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Product Notes
The UBE2E3 ube2e3 (Catalog #AAA1269547) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtccagtg ataggcaaag gtccgatgat gagagcccca gcaccagcag tggcagttca gatgcggacc agcgagaccc agccgctcca gagcctgaag aacaagagga aagaaaacct tctgccaccc agcagaagaa aaacaccaaa ctctctagca aaaccactgc taagttatcc actagtgcta aaagaattca gaaggagcta gctgaaataa cccttgatcc tcctcctaat tgcagtgctg ggcctaaagg agataacatt tatgaatgga gatcaactat acttggtcca ccgggttctg tatatgaagg tggtgtgttt tttctggata tcacattttc atcagattat ccatttaagc caccaaaggt tactttccgc accagaatct atcactgcaa catcaacagt cagggagtca tctgtctgga catccttaaa gacaactgga gtcccgcttt gactatttca aaggttttgc tgtctatttg ttcccttttg acagactgca accctgcgga tcctctggtt ggaagcatag ccactcagta tttgaccaac agagcagaac acgacaggat agccagacag tggaccaaga gatacgcaac ataa. It is sometimes possible for the material contained within the vial of "UBE2E3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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