UBD cdna clone
UBD cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
FAT10: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN).
Protein type: Ubiquitin-like modifier
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding
Biological Process: myeloid dendritic cell differentiation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein ubiquitination; ubiquitin-dependent protein catabolic process
Research Articles on UBD
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Product Notes
The UBD ubd (Catalog #AAA1273119) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctccca atgcttcctg cctctgtgtg catgtccgtt ccgaggaatg ggatttaatg acctttgatg ccaacccata tgacagcgtg aaaaaaatca aagaacatgt ccggtctaag accaaggttc ctgtgcagga ccaggttctt ttgctgggct ccaagatctt aaagccacgg agaagcctct catcttatgg cattgacaaa gagaagacca tccaccttac cctgaaagtg gtgaagccca gtgatgagga gctgcccttg tttcttgtgg agtcaggtga tgaggcaaag aggcacctcc tccaggtgcg aaggtccagc tcagtggcac aagtgaaagc aatgatcgag actaagacgg gtataatccc tgagacccag attgtgactt gcaatggaaa gagactggaa gatgggaaga tgatggcaga ttacggcatc agaaagggca acttactctt cctggcatgt tattgcattg gagggtga. It is sometimes possible for the material contained within the vial of "UBD, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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