TXNRD2 cdna clone
TXNRD2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
Uniprot Description
TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; EC 1.8.1.9; Nucleotide Metabolism - pyrimidine; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: protein binding; thioredoxin-disulfide reductase activity
Biological Process: response to oxygen radical; response to reactive oxygen species
Research Articles on TXNRD2
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Product Notes
The TXNRD2 txnrd2 (Catalog #AAA1269043) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGGCAA TGGCGGTGGC GCTGCGGGGA TTAGGAGGGC GCTTCCGGTG GCGGACGCAG GCCGTGGCGG GCGGGGTGCG GGGCGCGGCG CGGGGCGCAG CAGCAGGTCA GCGGGACTAT GATCTCCTGG TGGTCGGCGG GGGATCTGGT GGCCTGGCTT GTGCCAAGGA GGCCGCTCAG CTGGGAAGGA AGGTGGCCGT GGTGGACTAC GTGGAACCTT CTCCCCAAGG CACCCGGTGG GGCCTTGGCG GCACCTGCGT CAACGTGGGC TGCATCCCCA AGAAGCTGAT GCACCAGGCG GCACTGCTGG GAGGCCTGAT CCAAGATGCC CCCAACTATG GCTGGGAGGT GGCCCAGCCC GTGCCGCATG ACTGGAGGAA GATGGCAGAA GCTGTTCAAA ATCACGTGAA ATCCTTGAAC TGGGGCCACC GTGTCCAGCT TCAGGACAGA AAAGTCAAGT ACTTTAACAT CAAAGCCAGC TTTGTTGACG AGCACACGGT TTGCGGCGTT GCCAAAGGTG GGAAAGAGAT TCTGCTGTCA GCCGATCACA TCATCATTGC TACTGGAGGG CGGCCGAGAT ACCCCACGCA CATCGAAGGT GCCTTGGAAT ATGGAATCAC AAGTGATGAC ATCTTCTGGC TGAAGGAATC CCCTGGAAAA ACGTTGGTGG TCGGGGCCAG CTATGTGGCC CTGGAGTGTG CTGGCTTCCT CACCGGGATT GGGCTGGACA CCACCATCAT GATGCGCAGC ATCCCCCTCC GCGGCTTCGA CCAGCAAATG TCCTCCATGG TCATAGAGCA CATGGCATCT CATGGCACCC GGTTCCTGAG GGGCTGTGCC CCCTCGCGGG TCAGGAGGCT CCCTGATGGC CAGCTGCAGG TCACCTGGGA GGACCGCACC ACCGGCAAGG AGGACACGGG CACCTTTGAC ACCGTCCTGT GGGCCATAGC ACCTTGCATC TCTGCGTGTC TCCCCACCAC CGTGGGACAT GCTGGAAAAA ACCAGAGAAG AGACTGA. It is sometimes possible for the material contained within the vial of "TXNRD2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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