TRPM2 cdna clone
TRPM2 cDNA Clone
Gene Names
TRPM2; KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1
Synonyms
TRPM2; TRPM2 cDNA Clone; TRPM2 cdna clone
Sequence
ATGGAGCCCTCAGCCCTGAGGAAAGCTGGCTCGGAGCAGGAGGAGGGCTTTGAGGGGCTGCCCAGAAGGGTCACTGACCTGGGGATGGTCTCCAATCTCCGGCGCAGCAACAGCAGCCTCTTCAAGAGCTGGAGGCTACAGTGCCCCTTCGGCAACAATGACAAGCAAGAAAGCCTCAGTTCGTGGATTCCTGAAAACATCAAGAAGAAAGAATGCGTGTATTTTGTGGAAAGTTCCAAACTGTCTGATGCTGGGAAGGTGGTGTGTCAGTGTGGCTACACGCATGAGCAGCACTTGGAGGAGGCTACCAAGCCCCACACCTTCCAGGGCACACAGTGGGACCCAAAGAAACATGTCCAGGAGATGCCAACCGATGCCTTTGGCGACATCGTCTTCACGGGCCTGAGCCAGAAGGTGAAAAAGTACGTCCGAGTCTCCCAGGACACGCCCTCCAGCGTGATCTACCACCTCATGACCCAGCACTGGGGGCTGGACGTCCCCAATCTCTTGATCTCGGTGACCGGGGGGGCCAAGAACTTCAACATGAAGCCGCGGCTGAAGAGCATTTTCCGCAGAGGCCTGGTCAAGGTGGCTCAGACCACAGGGGCCTGGATCATCACAGGGGGGTCCCACACCGGCGTCATGAAGCAGGTAGGCGAGGCGGTGCGGGACTTCAGCCTGAGCAGCAGCTACAAGGAAGGCGAGCTCATCACCATCGGAGTCGCCACCTGGGGCACTGTCCACCGCCGCGAGGGCCTGATCCATCCCACGGGCAGCTTCCCCGCCGAGTACATACTGGATGAGGATGGCCAAGGGAACCTGACCTGCCTAGACAGCAACCACTCTCACTTCATCCTCGTGGACGACGGGACCCACGGCCAGTACGGGGTGGAGATTCCTCTGAGGACCAGGCTGGAGAAGTTCATATCGGAGCAGACCAAGGAAAGAGGAGGTGTGGCCATCAAGATCCCCATCGTGTGCGTGGTGCTGGAGGGCGGCCCGGGCACGTTGCACACCATCGACAACGCCACCACCAACGGCACCCCCTGTGTGGTTGTGGAGGGCTCGGGCCGCGTGGCCGACGTCATTGCCCAGGTGGCCAACCTGCCTGTCTCGGACATCACTATCTCCCTGATCCAGCAGAAACTGAGCGTGTTCTTCCAGGAGATGTTTGAGACCTTCACGGAAAGCAGGATTGTCGAGTGGACCAAAAAGATCCAAGATATCGTCCGGAGGCGGCAGCTGCTGACTGTCTTCCGGGAAGGCAAGGATGGTCAGCAGGACGTGGATGTGGCCATCTTGCAGGCCTTGCTGAAAGCCTCACGGAGCCAAGACCACTTTGGCCACGAGAACTGGGACCACCAGCTGAAACTGGCAGTGGCATGGAATCGCGTGGACATTGCCCGCAGTGAGATCTTCATGGATGAGTGGCAGTGGAAGCCTTCAGATCTGCACCCCACGATGACAGCTGCACTCATCTCCAACAAGCCTGAGTTTGTGAAGCTCTTCCTGGAGAACGGGGTGCAGCTGAAGGAGTTTGTCACCTGGGACACCTTGCTCTACCTGTACGAGAACCTGGACCCCTCCTGCCTGTTCCACAGCAAGCTGCAGAAGGTGCTGGTGGAGGATCCCGAGCGCCCGGCTTGCGCGCCCGCGGCGCCCCGCCTGCAGATGCACCACGTGGCCCAGGTGCTGCGGGAGCTGCTGGGGGACTTCACGCAGCCGCTTTATCCCCGGCCCCGGCACAACGACCGGCTGCGGCTCCTGCTGCCCGTTCCCCACGTCAAGCTCAACGTGCAGGGAGTGAGCCTCCGGTCCCTCTACAAGCGTTCCTCAGGCCATGTGACCTTCACCATGGACCCCATCCGTGACCTTCTCATTTGGGCCATTGTCCAGAACCGTCGGGAGCTGGCAGGAATCATCTGGGCTCAGAGCCAGGACTGCATCGCAGCGGCCTTGGCCTGCAGCAAGATCCTGAAGGAACTGTCCAAGGAGGAGGAGGACACGGACAGCTCGGAGGAGATGCTGGCGCTGGCGGAGGAGTATGAGCACAGAGCCATCGGGGTCTTCACCGAGTGCTACCGGAAGGACGAAGAGAGAGCCCAGAAACTGCTCACCCGCGTGTCCGAGGCCTGGGGGAAGACCACCTGCCTGCAGCTCGCCCTGGAGGCCAAGGACATGAAGTTTGTGTCTCACGGGGGCATCCAGGCCTTCCTGACCAAGGTGTGGTGGGGCCAGCTCTCCGTGGACAATGGGCTGTGGCGTGTGACCCTGTGCATGCTGGCCTTCCCGCTGCTCCTCACCGGCCTCATCTCCTTCAGGGAGAAGAGGCTGCAGGATGTGGGCACCCCCGCGGCCCGCGCCCGTGCCTTCTTCACCGCACCCGTGGTGGTCTTCCACCTGAACATCCTCTCCTACTTCGCCTTCCTCTGCCTGTTCGCCTACGTGCTCATGGTGGACTTCCAGCCTGTGCCCTCCTGGTGCGAGTGTGCCATCTACCTCTGGCTCTTCTCCTTGGTGTGCGAGGAGATGCGGCAGCTCTTCTATGACCCTGACGAGTGCGGGCTGATGAAGAAGGCAGCCTTGTACTTCAGTGACTTCTGGAATAAGCTGGACGTCGGCGCAATCTTGCTCTTCGTGGCAGGGCTGACCTGCAGGCTCATCCCGGCGACGCTGTACCCCGGGCGCGTCATCCTCTCTCTGGACTTCATCCTGTTCTGCCTCCGGCTCATGCACATTTTTACCATCAGTAAGACGCTGGGGCCCAAGATCATCATTGTGAAGCGGATGATGAAGGACGTCTTCTTCTTCCTCTTCCTGCTGGCTGTGTGGGTGGTGTCCTTCGGGGTGGCCAAGCAGGCCATCCTCATCCACAACGAGCGCCGGGTGGACTGGCTGTTCCGAGGGGCCGTCTACCACTCCTACCTCACCATCTTCGGGCAGATCCCGGGCTACATCGACGGTGTGAACTTCAACCCGGAGCACTGCAGCCCCAATGGCACCGACCCCTACAAGCCTAAGTGCCCCGAGAGCGACGCGACGCAGCAGAGGCCGGCCTTCCCTGAGTGGCTGACGGTCCTCCTACTCTGCCTCTACCTGCTCTTCACCAACATCCTGCTGCTCAACCTCCTCATCGCCATGTTCAACTACACCTTCCAGCAGGTGCAGGAGCACACGGACCAGATTTGGAAGTTCCAGCGCCATGACCTGATCGAGGAGTACCACGGCCGCCCCGCCGCGCCGCCCCCCTTCATCCTCCTCAGCCACCTGCAGCTCTTCATCAAGAGGGTGGTCCTGAAGACTCCGGCCAAGAGGCACAAGCAGCTCAAGAACAAGCTGGAGAAGAACGAGGAGGCGGCCCTGCTATCCTGGGAGATCTACCTGAAGGAGAACTACCTCCAGAACCGACAGTTCCAGCAAAAGCAGCGGCCCGAGCAGAAGATCGAGGACATCAGCAATAAGGCAGGGCTGGAGCTTTGGGGGTCAAGGACAAGCTCTGTCTGCAAATCTAGACAGTTCCTGCATCTCACGGTGGTGGAATCACGCGGGTCCGAGAAGGCTCCAGTAACCACCCTCGCATGTTTGCAAGGCTGTCTGGGAAAACATGGCAGGGTTGACGCCATGGTGGACCTGCTGGACCTGGACCCACTGAAGAGGTCGGGCTCCATGGAGCAGAGGTTGGCCTCCCTGGAGGAGCAGGTGGCCCAGACAGCCCGAGCCCTGCACTGGATCGTGAGGACGCTGCGGGCCAGCGGCTTCAGCTCGGAGGCGGACGTCCCCACTCTGGCCTCCCAGAAGGCCGCGGAGGAGCCGGATGCTGAGCCGGGAGGCAGGAAGAAGACGGAGGAGCCGGGCGACAGCTACCACGTGAATGCCCGGCACCTCCTCTACCCCAACTGCCCTGTCACGCGCTTCCCCGTGCCCAACGAGAAGGTGCCCTGGGAGACGGAGTTCCTGATCTATGACCCACCCTTTTACACGGCAGAGAGGAAGGACGCGGCCGCCATGGACCCCATGGGAGACACCCTGGAGCCACTGTCCACGATCCAGTACAACGTGGTGGATGGCCTGAGGGACCGCCGGAGCTTCCACGGGCCGTACACAGTGCAGGCCGGGTTGCCCCTGAACCCCATGGGCCGCACAGGACTGCGTGGGCGCGGGAGCCTCAGCTGCTTCGGACCCAACCACACGCTGTACCCCATGGTCACGCGGTGGAGGCGGAACGAGGATGGAGCCATCTGCAGGAAGAGCATAAAGAAGATGCTGGAAGTGCTGGTGGTGAAGCTCCCTCTCTCCGAGCACTGGGCCCTGCCTGGGGGCTCCCGGGAGCCAGGGGAGATGCTACCTCGGAAGCTGAAGCGGATCCTCCGGCAGGAGCACTGGCCGTCTTTTGAAAACTTGCTGAAGTGCGGCATGGAGGTGTACAAAGGCTACATGGATGACCCGAGGAACACGGACAATGCCTGGATCGAGACGGTGGCCGTCAGCGTCCACTTCCAGGACCAGAATGACGTGGAGCTGAACAGGCTGAACTCTAACCTGCACGCCTGCGACTCGGGGGCCTCCATCCGATGGCAGGTGGTGGACAGGCGCATCCCACTCTATGCGAACCACAAGACCCTCCTCCAGAAGGCAGCCGCTGAGTTCGGGGCTCACTACTGA
Sequence Length
4662
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
95,699 Da
NCBI Official Full Name
Homo sapiens transient receptor potential cation channel, subfamily M, member 2, mRNA
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily M member 2
NCBI Official Symbol
TRPM2
NCBI Official Synonym Symbols
KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1
NCBI Protein Information
transient receptor potential cation channel subfamily M member 2
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 2
Protein Family
UniProt Gene Name
TRPM2
UniProt Synonym Gene Names
EREG1; KNP3; LTRPC2; TRPC7; LTrpC-2; LTrpC2; TrpC7
UniProt Entry Name
TRPM2_HUMAN
NCBI Description
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
Uniprot Description
TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter; Channel, calcium; EC 3.6.1.13; Membrane protein, integral; Hydrolase
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: calcium channel activity
Biological Process: calcium ion transport
Research Articles on TRPM2
Similar Products
Product Notes
The TRPM2 trpm2 (Catalog #AAA1272757) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGCCCT CAGCCCTGAG GAAAGCTGGC TCGGAGCAGG AGGAGGGCTT TGAGGGGCTG CCCAGAAGGG TCACTGACCT GGGGATGGTC TCCAATCTCC GGCGCAGCAA CAGCAGCCTC TTCAAGAGCT GGAGGCTACA GTGCCCCTTC GGCAACAATG ACAAGCAAGA AAGCCTCAGT TCGTGGATTC CTGAAAACAT CAAGAAGAAA GAATGCGTGT ATTTTGTGGA AAGTTCCAAA CTGTCTGATG CTGGGAAGGT GGTGTGTCAG TGTGGCTACA CGCATGAGCA GCACTTGGAG GAGGCTACCA AGCCCCACAC CTTCCAGGGC ACACAGTGGG ACCCAAAGAA ACATGTCCAG GAGATGCCAA CCGATGCCTT TGGCGACATC GTCTTCACGG GCCTGAGCCA GAAGGTGAAA AAGTACGTCC GAGTCTCCCA GGACACGCCC TCCAGCGTGA TCTACCACCT CATGACCCAG CACTGGGGGC TGGACGTCCC CAATCTCTTG ATCTCGGTGA CCGGGGGGGC CAAGAACTTC AACATGAAGC CGCGGCTGAA GAGCATTTTC CGCAGAGGCC TGGTCAAGGT GGCTCAGACC ACAGGGGCCT GGATCATCAC AGGGGGGTCC CACACCGGCG TCATGAAGCA GGTAGGCGAG GCGGTGCGGG ACTTCAGCCT GAGCAGCAGC TACAAGGAAG GCGAGCTCAT CACCATCGGA GTCGCCACCT GGGGCACTGT CCACCGCCGC GAGGGCCTGA TCCATCCCAC GGGCAGCTTC CCCGCCGAGT ACATACTGGA TGAGGATGGC CAAGGGAACC TGACCTGCCT AGACAGCAAC CACTCTCACT TCATCCTCGT GGACGACGGG ACCCACGGCC AGTACGGGGT GGAGATTCCT CTGAGGACCA GGCTGGAGAA GTTCATATCG GAGCAGACCA AGGAAAGAGG AGGTGTGGCC ATCAAGATCC CCATCGTGTG CGTGGTGCTG GAGGGCGGCC CGGGCACGTT GCACACCATC GACAACGCCA CCACCAACGG CACCCCCTGT GTGGTTGTGG AGGGCTCGGG CCGCGTGGCC GACGTCATTG CCCAGGTGGC CAACCTGCCT GTCTCGGACA TCACTATCTC CCTGATCCAG CAGAAACTGA GCGTGTTCTT CCAGGAGATG TTTGAGACCT TCACGGAAAG CAGGATTGTC GAGTGGACCA AAAAGATCCA AGATATCGTC CGGAGGCGGC AGCTGCTGAC TGTCTTCCGG GAAGGCAAGG ATGGTCAGCA GGACGTGGAT GTGGCCATCT TGCAGGCCTT GCTGAAAGCC TCACGGAGCC AAGACCACTT TGGCCACGAG AACTGGGACC ACCAGCTGAA ACTGGCAGTG GCATGGAATC GCGTGGACAT TGCCCGCAGT GAGATCTTCA TGGATGAGTG GCAGTGGAAG CCTTCAGATC TGCACCCCAC GATGACAGCT GCACTCATCT CCAACAAGCC TGAGTTTGTG AAGCTCTTCC TGGAGAACGG GGTGCAGCTG AAGGAGTTTG TCACCTGGGA CACCTTGCTC TACCTGTACG AGAACCTGGA CCCCTCCTGC CTGTTCCACA GCAAGCTGCA GAAGGTGCTG GTGGAGGATC CCGAGCGCCC GGCTTGCGCG CCCGCGGCGC CCCGCCTGCA GATGCACCAC GTGGCCCAGG TGCTGCGGGA GCTGCTGGGG GACTTCACGC AGCCGCTTTA TCCCCGGCCC CGGCACAACG ACCGGCTGCG GCTCCTGCTG CCCGTTCCCC ACGTCAAGCT CAACGTGCAG GGAGTGAGCC TCCGGTCCCT CTACAAGCGT TCCTCAGGCC ATGTGACCTT CACCATGGAC CCCATCCGTG ACCTTCTCAT TTGGGCCATT GTCCAGAACC GTCGGGAGCT GGCAGGAATC ATCTGGGCTC AGAGCCAGGA CTGCATCGCA GCGGCCTTGG CCTGCAGCAA GATCCTGAAG GAACTGTCCA AGGAGGAGGA GGACACGGAC AGCTCGGAGG AGATGCTGGC GCTGGCGGAG GAGTATGAGC ACAGAGCCAT CGGGGTCTTC ACCGAGTGCT ACCGGAAGGA CGAAGAGAGA GCCCAGAAAC TGCTCACCCG CGTGTCCGAG GCCTGGGGGA AGACCACCTG CCTGCAGCTC GCCCTGGAGG CCAAGGACAT GAAGTTTGTG TCTCACGGGG GCATCCAGGC CTTCCTGACC AAGGTGTGGT GGGGCCAGCT CTCCGTGGAC AATGGGCTGT GGCGTGTGAC CCTGTGCATG CTGGCCTTCC CGCTGCTCCT CACCGGCCTC ATCTCCTTCA GGGAGAAGAG GCTGCAGGAT GTGGGCACCC CCGCGGCCCG CGCCCGTGCC TTCTTCACCG CACCCGTGGT GGTCTTCCAC CTGAACATCC TCTCCTACTT CGCCTTCCTC TGCCTGTTCG CCTACGTGCT CATGGTGGAC TTCCAGCCTG TGCCCTCCTG GTGCGAGTGT GCCATCTACC TCTGGCTCTT CTCCTTGGTG TGCGAGGAGA TGCGGCAGCT CTTCTATGAC CCTGACGAGT GCGGGCTGAT GAAGAAGGCA GCCTTGTACT TCAGTGACTT CTGGAATAAG CTGGACGTCG GCGCAATCTT GCTCTTCGTG GCAGGGCTGA CCTGCAGGCT CATCCCGGCG ACGCTGTACC CCGGGCGCGT CATCCTCTCT CTGGACTTCA TCCTGTTCTG CCTCCGGCTC ATGCACATTT TTACCATCAG TAAGACGCTG GGGCCCAAGA TCATCATTGT GAAGCGGATG ATGAAGGACG TCTTCTTCTT CCTCTTCCTG CTGGCTGTGT GGGTGGTGTC CTTCGGGGTG GCCAAGCAGG CCATCCTCAT CCACAACGAG CGCCGGGTGG ACTGGCTGTT CCGAGGGGCC GTCTACCACT CCTACCTCAC CATCTTCGGG CAGATCCCGG GCTACATCGA CGGTGTGAAC TTCAACCCGG AGCACTGCAG CCCCAATGGC ACCGACCCCT ACAAGCCTAA GTGCCCCGAG AGCGACGCGA CGCAGCAGAG GCCGGCCTTC CCTGAGTGGC TGACGGTCCT CCTACTCTGC CTCTACCTGC TCTTCACCAA CATCCTGCTG CTCAACCTCC TCATCGCCAT GTTCAACTAC ACCTTCCAGC AGGTGCAGGA GCACACGGAC CAGATTTGGA AGTTCCAGCG CCATGACCTG ATCGAGGAGT ACCACGGCCG CCCCGCCGCG CCGCCCCCCT TCATCCTCCT CAGCCACCTG CAGCTCTTCA TCAAGAGGGT GGTCCTGAAG ACTCCGGCCA AGAGGCACAA GCAGCTCAAG AACAAGCTGG AGAAGAACGA GGAGGCGGCC CTGCTATCCT GGGAGATCTA CCTGAAGGAG AACTACCTCC AGAACCGACA GTTCCAGCAA AAGCAGCGGC CCGAGCAGAA GATCGAGGAC ATCAGCAATA AGGCAGGGCT GGAGCTTTGG GGGTCAAGGA CAAGCTCTGT CTGCAAATCT AGACAGTTCC TGCATCTCAC GGTGGTGGAA TCACGCGGGT CCGAGAAGGC TCCAGTAACC ACCCTCGCAT GTTTGCAAGG CTGTCTGGGA AAACATGGCA GGGTTGACGC CATGGTGGAC CTGCTGGACC TGGACCCACT GAAGAGGTCG GGCTCCATGG AGCAGAGGTT GGCCTCCCTG GAGGAGCAGG TGGCCCAGAC AGCCCGAGCC CTGCACTGGA TCGTGAGGAC GCTGCGGGCC AGCGGCTTCA GCTCGGAGGC GGACGTCCCC ACTCTGGCCT CCCAGAAGGC CGCGGAGGAG CCGGATGCTG AGCCGGGAGG CAGGAAGAAG ACGGAGGAGC CGGGCGACAG CTACCACGTG AATGCCCGGC ACCTCCTCTA CCCCAACTGC CCTGTCACGC GCTTCCCCGT GCCCAACGAG AAGGTGCCCT GGGAGACGGA GTTCCTGATC TATGACCCAC CCTTTTACAC GGCAGAGAGG AAGGACGCGG CCGCCATGGA CCCCATGGGA GACACCCTGG AGCCACTGTC CACGATCCAG TACAACGTGG TGGATGGCCT GAGGGACCGC CGGAGCTTCC ACGGGCCGTA CACAGTGCAG GCCGGGTTGC CCCTGAACCC CATGGGCCGC ACAGGACTGC GTGGGCGCGG GAGCCTCAGC TGCTTCGGAC CCAACCACAC GCTGTACCCC ATGGTCACGC GGTGGAGGCG GAACGAGGAT GGAGCCATCT GCAGGAAGAG CATAAAGAAG ATGCTGGAAG TGCTGGTGGT GAAGCTCCCT CTCTCCGAGC ACTGGGCCCT GCCTGGGGGC TCCCGGGAGC CAGGGGAGAT GCTACCTCGG AAGCTGAAGC GGATCCTCCG GCAGGAGCAC TGGCCGTCTT TTGAAAACTT GCTGAAGTGC GGCATGGAGG TGTACAAAGG CTACATGGAT GACCCGAGGA ACACGGACAA TGCCTGGATC GAGACGGTGG CCGTCAGCGT CCACTTCCAG GACCAGAATG ACGTGGAGCT GAACAGGCTG AACTCTAACC TGCACGCCTG CGACTCGGGG GCCTCCATCC GATGGCAGGT GGTGGACAGG CGCATCCCAC TCTATGCGAA CCACAAGACC CTCCTCCAGA AGGCAGCCGC TGAGTTCGGG GCTCACTACT GA. It is sometimes possible for the material contained within the vial of "TRPM2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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