TRPC4 cdna clone
TRPC4 cDNA Clone
Gene Names
TRPC4; TRP4; HTRP4; HTRP-4
Synonyms
TRPC4; TRPC4 cDNA Clone; TRPC4 cdna clone
Sequence
ATGGCTCAGTTCTATTACAAAAGAAATGTTAATGCTCCCTATAGAGACCGCATCCCTCTAAGGATAGTAAGAGCAGAATCAGAACTCTCGCCATCAGAAAAAGCCTACTTGAATGCTGTGGAAAAGGGAGATTATGCCAGTGTCAAGAAATCCCTAGAGGAAGCTGAAATTTATTTTAAAATCAATATTAATTGCATTGATCCTCTCGGAAGAACTGCTCTCCTCATTGCAATTGAAAATGAGAACTTGGAGCTCATCGAACTACTCTTAAGCTTTAATGTCTATGTTGGAGATGCTCTATTACATGCTATCAGAAAAGAAGTCGTCGGAGCTGTTGAGCTGTTATTGAACCACAAAAAACCTAGTGGAGAAAAACAGGTGCCTCCTATACTCCTTGATAAGCAGTTCTCTGAATTCACTCCAGACATTACACCAATCATTTTGGCAGCCCATACAAATAATTATGAGATAATAAAACTCTTGGTTCAGAAAGGAGTCTCAGTGCCTCGACCCCACGAGGTCCGCTGTAACTGTGTGGAATGCGTGTCCAGTTCAGATGTGGACAGCCTCCGTCACTCACGCTCCAGACTCAACATCTACAAGGCCTTGGCCAGTCCCTCTCTCATTGCACTGTCAAGCGAAGATCCTTTTCTCACAGCCTTTCAGTTAAGTTGGGAACTTCAGGAACTGAGCAAGGTGGAAAATGAATTCAAGTCGGAGTATGAAGAGCTGTCACGGCAGTGCAAACAATTTGCTAAGGACCTACTGGATCAGACGAGAAGTTCCAGAGAACTGGAAATCATTCTTAATTACCGAGATGACAATAGTCTCATAGAAGAACAAAGTGGAAATGATCTTGCAAGACTAAAATTGGCCATTAAGTACCGTCAAAAAGAGTTTGTTGCCCAGCCCAATTGTCAACAGCTGCTGGCATCTCGCTGGTACGATGAGTTTCCAGGCTGGAGGAGAAGACACTGGGCAGTGAAGATGGTGACATGTTTCATAATAGGACTTCTTTTTCCTGTCTTCTCTGTGTGCTACCTGATAGCTCCCAAAAGCCCACTTGGACTGTTCATCAGGAAGCCATTTATCAAGTTTATCTGCCACACAGCCTCCTATTTGACTTTTTTGTTCCTGCTGCTGCTTGCCTCTCAGCACATCGACAGGTCAGACTTGAACAGGCAAGGTCCACCACCAACCATCGTCGAGTGGATGATATTACCGTGGGTCCTGGGCTTCATATGGGGAGAAATTAAACAGATGTGGGATGGCGGACTTCAGGACTACATCCATGATTGGTGGAATCTAATGGACTTTGTAATGAACTCCTTATATTTAGCAACAATCTCCTTGAAAATTGTTGCATTTGTAAAGTACAGTGCCCTTAATCCACGAGAATCATGGGACATGTGGCATCCCACTCTGGTGGCAGAGGCTTTATTTGCTATTGCAAACATCTTCAGTTCTCTGCGTCTGATCTCACTGTTTACTGCAAATTCTCACCTGGGACCTCTGCAAATATCTCTGGGAAGAATGCTCCTGGACATTTTGAAGTTTCTATTCATATACTGCCTTGTGTTGCTAGCATTTGCAAATGGCCTAAATCAATTGTACTTCTATTATGAAGAAACGAAAGGGTTAACCTGCAAAGGCATAAGATGTGAAAAGCAGAATAATGCATTTTCAACGTTATTTGAGACACTGCAGTCCCTGTTTTGGTCAATATTTGGGCTCATCAATTTATATGTGACCAATGTCAAAGCACAGCATGAATTTACTGAGTTTGTTGGTGCCACCATGTTTGGGACATACAATGTCATCTCTCTGGTTGTTCTACTCAACATGTTAATAGCTATGATGAATAATTCTTACCAACTGATTGCTGACCATGCAGATATAGAATGGAAATTTGCACGAACAAAGCTTTGGATGAGTTATTTTGAAGAAGGAGGTACTCTGCCTACTCCCTTCAATGTCATCCCGAGCCCCAAGTCTCTCTGGTACCTGATCAAATGGATCTGGACACACTTGTGCAAGAAAAAGATGAGAAGAAAGCCAGAAAGTTTTGGAACAATAGGGAGGCGAGCTGCTGATAACTTGAGAAGACATCACCAATACCAAGAAGTTATGAGGAACCTGGTGAAGCGATACGTTGCTGCAATGATTAGAGATGCTAAAACTGAAGAAGGCCTGACCGAAGAGAACTTTAAGGAACTAAAGCAAGACATTTCTAGTTTCCGCTTTGAAGTCCTGGGATTACTAAGAGGAAGCAAACTTTCCACAATACAATCTGCGAATGCCTCGAAGGAGTCTTCAAATTCGGCAGACTCAGATGAAAAGAGTGATAGCGAAGGTAATAGCAAGGACAAGAAAAAGAATTTCAGCCTTTTTGATTTAACCACCCTGATTCATCCGAGATCAGCAGCAATTGCCTCTGAAAGACATAACATAAGCAATGGCTCTGCCCTGGTGGTTCAGGAGCCGCCCAGGGAGAAGCAGAGAAAAGTGAATTTTGTGACCGATATCAAAAACTTTGGGTTATTTCATAGACGATCAAAACAAAATGCTGCTGAGCAAAATGCAAACCAAATCTTCTCTGTTTCAGAAGAAGTTGCTCGTCAACAGGCTGCAGGACCACTTGAGAGAAATATTCAACTGGAATCTCGAGGATTAGCTTCACGGGGTGACCTGAGCATTCCCGGTCTCAGTGAACAATGTGTGTTAGTAGACCATAGAGAAAGGAATACGGACACACTGGGGTTACAGGTAGGAAAGAGAGTGTGTCCATTCAAGTCAGAGAAGGTGGTGGTGGAGGACACGGTTCCTATAATACCAAAGGAGAAACATGCAAAAGAAGAGGACTCTAGTATAGACTATGATCTAAACCTCCCAGACACAGTCACCCACGAAGATTACGTGACCACAAGATTGTGA
Sequence Length
2934
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
36,759 Da
NCBI Official Full Name
Homo sapiens transient receptor potential cation channel, subfamily C, member 4, mRNA
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily C member 4
NCBI Official Symbol
TRPC4
NCBI Official Synonym Symbols
TRP4; HTRP4; HTRP-4
NCBI Protein Information
short transient receptor potential channel 4
UniProt Protein Name
Short transient receptor potential channel 4
Protein Family
UniProt Gene Name
TRPC4
UniProt Synonym Gene Names
TrpC4; hTrp-4; hTrp4
UniProt Entry Name
TRPC4_HUMAN
NCBI Description
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
TRPC4: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q13.3
Cellular Component: basolateral plasma membrane; cell surface; cortical cytoskeleton; integral to plasma membrane; intercellular junction; plasma membrane
Molecular Function: beta-catenin binding; cadherin binding; calcium channel activity; protein binding; store-operated calcium channel activity
Biological Process: calcium ion transport; cytosolic calcium ion homeostasis; manganese ion transport
Research Articles on TRPC4
Similar Products
Product Notes
The TRPC4 trpc4 (Catalog #AAA1268207) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCTCAGT TCTATTACAA AAGAAATGTT AATGCTCCCT ATAGAGACCG CATCCCTCTA AGGATAGTAA GAGCAGAATC AGAACTCTCG CCATCAGAAA AAGCCTACTT GAATGCTGTG GAAAAGGGAG ATTATGCCAG TGTCAAGAAA TCCCTAGAGG AAGCTGAAAT TTATTTTAAA ATCAATATTA ATTGCATTGA TCCTCTCGGA AGAACTGCTC TCCTCATTGC AATTGAAAAT GAGAACTTGG AGCTCATCGA ACTACTCTTA AGCTTTAATG TCTATGTTGG AGATGCTCTA TTACATGCTA TCAGAAAAGA AGTCGTCGGA GCTGTTGAGC TGTTATTGAA CCACAAAAAA CCTAGTGGAG AAAAACAGGT GCCTCCTATA CTCCTTGATA AGCAGTTCTC TGAATTCACT CCAGACATTA CACCAATCAT TTTGGCAGCC CATACAAATA ATTATGAGAT AATAAAACTC TTGGTTCAGA AAGGAGTCTC AGTGCCTCGA CCCCACGAGG TCCGCTGTAA CTGTGTGGAA TGCGTGTCCA GTTCAGATGT GGACAGCCTC CGTCACTCAC GCTCCAGACT CAACATCTAC AAGGCCTTGG CCAGTCCCTC TCTCATTGCA CTGTCAAGCG AAGATCCTTT TCTCACAGCC TTTCAGTTAA GTTGGGAACT TCAGGAACTG AGCAAGGTGG AAAATGAATT CAAGTCGGAG TATGAAGAGC TGTCACGGCA GTGCAAACAA TTTGCTAAGG ACCTACTGGA TCAGACGAGA AGTTCCAGAG AACTGGAAAT CATTCTTAAT TACCGAGATG ACAATAGTCT CATAGAAGAA CAAAGTGGAA ATGATCTTGC AAGACTAAAA TTGGCCATTA AGTACCGTCA AAAAGAGTTT GTTGCCCAGC CCAATTGTCA ACAGCTGCTG GCATCTCGCT GGTACGATGA GTTTCCAGGC TGGAGGAGAA GACACTGGGC AGTGAAGATG GTGACATGTT TCATAATAGG ACTTCTTTTT CCTGTCTTCT CTGTGTGCTA CCTGATAGCT CCCAAAAGCC CACTTGGACT GTTCATCAGG AAGCCATTTA TCAAGTTTAT CTGCCACACA GCCTCCTATT TGACTTTTTT GTTCCTGCTG CTGCTTGCCT CTCAGCACAT CGACAGGTCA GACTTGAACA GGCAAGGTCC ACCACCAACC ATCGTCGAGT GGATGATATT ACCGTGGGTC CTGGGCTTCA TATGGGGAGA AATTAAACAG ATGTGGGATG GCGGACTTCA GGACTACATC CATGATTGGT GGAATCTAAT GGACTTTGTA ATGAACTCCT TATATTTAGC AACAATCTCC TTGAAAATTG TTGCATTTGT AAAGTACAGT GCCCTTAATC CACGAGAATC ATGGGACATG TGGCATCCCA CTCTGGTGGC AGAGGCTTTA TTTGCTATTG CAAACATCTT CAGTTCTCTG CGTCTGATCT CACTGTTTAC TGCAAATTCT CACCTGGGAC CTCTGCAAAT ATCTCTGGGA AGAATGCTCC TGGACATTTT GAAGTTTCTA TTCATATACT GCCTTGTGTT GCTAGCATTT GCAAATGGCC TAAATCAATT GTACTTCTAT TATGAAGAAA CGAAAGGGTT AACCTGCAAA GGCATAAGAT GTGAAAAGCA GAATAATGCA TTTTCAACGT TATTTGAGAC ACTGCAGTCC CTGTTTTGGT CAATATTTGG GCTCATCAAT TTATATGTGA CCAATGTCAA AGCACAGCAT GAATTTACTG AGTTTGTTGG TGCCACCATG TTTGGGACAT ACAATGTCAT CTCTCTGGTT GTTCTACTCA ACATGTTAAT AGCTATGATG AATAATTCTT ACCAACTGAT TGCTGACCAT GCAGATATAG AATGGAAATT TGCACGAACA AAGCTTTGGA TGAGTTATTT TGAAGAAGGA GGTACTCTGC CTACTCCCTT CAATGTCATC CCGAGCCCCA AGTCTCTCTG GTACCTGATC AAATGGATCT GGACACACTT GTGCAAGAAA AAGATGAGAA GAAAGCCAGA AAGTTTTGGA ACAATAGGGA GGCGAGCTGC TGATAACTTG AGAAGACATC ACCAATACCA AGAAGTTATG AGGAACCTGG TGAAGCGATA CGTTGCTGCA ATGATTAGAG ATGCTAAAAC TGAAGAAGGC CTGACCGAAG AGAACTTTAA GGAACTAAAG CAAGACATTT CTAGTTTCCG CTTTGAAGTC CTGGGATTAC TAAGAGGAAG CAAACTTTCC ACAATACAAT CTGCGAATGC CTCGAAGGAG TCTTCAAATT CGGCAGACTC AGATGAAAAG AGTGATAGCG AAGGTAATAG CAAGGACAAG AAAAAGAATT TCAGCCTTTT TGATTTAACC ACCCTGATTC ATCCGAGATC AGCAGCAATT GCCTCTGAAA GACATAACAT AAGCAATGGC TCTGCCCTGG TGGTTCAGGA GCCGCCCAGG GAGAAGCAGA GAAAAGTGAA TTTTGTGACC GATATCAAAA ACTTTGGGTT ATTTCATAGA CGATCAAAAC AAAATGCTGC TGAGCAAAAT GCAAACCAAA TCTTCTCTGT TTCAGAAGAA GTTGCTCGTC AACAGGCTGC AGGACCACTT GAGAGAAATA TTCAACTGGA ATCTCGAGGA TTAGCTTCAC GGGGTGACCT GAGCATTCCC GGTCTCAGTG AACAATGTGT GTTAGTAGAC CATAGAGAAA GGAATACGGA CACACTGGGG TTACAGGTAG GAAAGAGAGT GTGTCCATTC AAGTCAGAGA AGGTGGTGGT GGAGGACACG GTTCCTATAA TACCAAAGGA GAAACATGCA AAAGAAGAGG ACTCTAGTAT AGACTATGAT CTAAACCTCC CAGACACAGT CACCCACGAA GATTACGTGA CCACAAGATT GTGA. It is sometimes possible for the material contained within the vial of "TRPC4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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