TRPC1 cdna clone
TRPC1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
TRPC1: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 3q23
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: calcium channel activity; cation channel activity; protein binding; store-operated calcium channel activity
Biological Process: calcium ion transport; cytosolic calcium ion homeostasis; manganese ion transport; melanin biosynthetic process; positive regulation of release of sequestered calcium ion into cytosol; response to calcium ion
Research Articles on TRPC1
Similar Products
Product Notes
The TRPC1 trpc1 (Catalog #AAA1271531) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGATGGCGG CCCTGTACCC GAGCACGGAC CTCTCGGGCG CCTCCTCCTC CTCCCTGCCT TCCTCTCCAT CCTCTTCCTC GCCGAACGAG GTGATGGCGC TGAAGGATGT GCGGGAGGTG AAGGAGGAGA ATACGCTGAA TGAGAAGCTT TTCTTGCTGG CGTGCGACAA GGGTGACTAT TATATGGTTA AAAAGATTTT GGAGGAAAAC AGTTCAGGTG ACTTGAACAT AAATTGCGTA GATGTGCTTG GGAGAAATGC TGTTACCATA ACTATTGAAA ACGAAAACTT GGATATACTG CAGCTTCTTT TGGACTACGG TTGTCAGAAA CTAATGGAAC GAATTCAGAA TCCTGAGTAT TCAACAACTA TGGATGTTGC ACCTGTCATT TTAGCTGCTC ATCGTAACAA CTATGAAATT CTTACAATGC TCTTAAAACA GGATGTATCT CTACCCAAGC CCCATGCAGT TGGCTGTGAA TGCACATTGT GTTCTGCAAA AAACAAAAAG GATAGCCTCC GGCATTCCAG GTTTCGTCTT GATATATATC GATGTTTGGC CAGTCCAGCT CTAATAATGT TAACAGAGGA GGATCCAATT CTGAGAGCAT TTGAACTTAG TGCTGATTTA AAAGAACTAA GTCTTGTGGA GGTGGAATTC AGGAATGATT ATGAGGAACT AGCCCGGCAA TGTAAAATGT TTGCTAAGGA TTTACTTGCA CAAGCCCGGA ATTCTCGTGA ATTGGAAGTT ATTCTAAACC ATACGTCTAG TGACGAGCCT CTTGACAAAC GGGGATTATT AGAAGAAAGA ATGAATTTAA GTCGTCTAAA ACTTGCTATC AAATATAACC AGAAAGAGTT TGTCTCCCAG TCTAACTGCC AGCAGTTCCT GAACACTGTT TGGTTTGGAC AGATGTCGGG TTACCGACGC AAGCCCACCT GTAAGAAGAT AATGACTGTT TTGACAGTAG GCATCTTTTG GCCAGTTTTG TCACTTTGTT ATTTGATAGC TCCCAAATCT CAGTTTGGCA GAATCATTCA CACACCTTTT ATGAAATTTA TCATTCATGG AGCATCATAT TTCACATTTC TGCTGTTGCT TAATCTATAC TCTCTTGTCT ACAATGAGGA TAAGAAAAAC ACAATGGGGC CAGCCCTTGA AAGAATAGAC TATCTTCTTA TTCTGTGGAT TATTGGGATG ATTTGGTCAG ACATTAAAAG ACTCTGGTAT GAAGGGTTGG AAGACTTTTT AGAAGAATCT CGTAATCAAC TCAGTTTTGT CATGAATTCT CTTTATTTGG CAACCTTTGC CCTCAAAGTG GTTGCTCACA ACAAGTTTCA TGATTTTGCT GATCGGAAGG ATTGGGATGC ATTCCATCCT ACACTGGTGG CAGAAGGGCT TTTTGCATTT GCAAATGTTC TAAGTTATCT TCGTCTCTTT TTTATGTATA CAACCAGCTC TATCTTGGGT CCATTACAGA TTTCAATGGG ACAGATGTTA CAAGATTTTG GAAAATTTCT TGGGATGTTT CTTCTTGTTT TGTTTTCTTT CACAATTGGA CTGACACAAC TGTATGATAA AGGATATACT TCAAAGGAGC AGAAGGACTG TGTAGGCATC TTCTGTGAAC AGCAAAGCAA TGATACCTTC CATTCGTTCA TTGGCACCTG CTTTGCTTTG TTCTGGTATA TTTTCTCCTT AGCGCATGTG GCAATCTTTG TCACAAGATT TAGCTATGGA GAAGAACTGC AGTCCTTTGT GGGAGCTGTC ATTGTTGGTA CATACAATGT CGTGGTTGTG ATTGTGCTTA CCAAACTGCT GGTGGCAATG CTTCATAAAA GCTTTCAGTT GATAGCAAAT CATGAAGACA AAGAATGGAA GTTTGCTCGA GCAAAATTAT GGCTTAGCTA CTTTGATGAC AAATGTACGT TACCTCCACC TTTCAACATC ATTCCCTCAC CAAAGACTAT CTGCTATATG ATTAGTAGCC TCAGTAAGTG GATTTGCTCT CATACATCAA AAGGCAAGGT CAAACGGCAA AACAGTTTAA AGGAATGGAG GAATTTGAAA CAGAAGAGAG ATGAAAACTA TCAAAAAGTG ATGTGCTGCC TAGTGCATCG TTACTTGACT TCCATGAGAC AGAAGATGCA AAGTACAGAT CAGGCAACTG TGGAAAATCT AAACGAACTG CGCCAAGATC TGTCAAAATT CCGAAATGAA ATAAGGGATT TACTTGGCTT TCGGACTTCT AAATATGCTA TGTTTTATCC AAGAAATTAA. It is sometimes possible for the material contained within the vial of "TRPC1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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