TP53BP2 cdna clone

TP53BP2 cDNA Clone

Gene Names

TP53BP2; BBP; 53BP2; ASPP2; P53BP2; PPP1R13A

Synonyms

TP53BP2; TP53BP2 cDNA Clone; TP53BP2 cdna clone

Ordering
Cat. Num. AAA1278986 For Research Use Only!

Sequence

ATGAACGCCCCCCTGGCAGGGACATTGGTAGTGAGTGGACCAAGATCTCAGGATCCAAGTTTAAAAAGAAATGGTGTAAAAGTTCCTGGTGAATATCGAAGAAAGGAGAACGGTGTTAATAGTCCTAGGATGGATCTGACTCTTGCTGAACTTCAGGAAATGGCATCTCGCCAGCAGCAACAGATTGAAGCCCAGCAACAATTGCTGGCAACTAAGGAACAGCGCTTAAAGTTTTTGAAACAACAAGATCAGCGACAACAGCAACAAGTTGCTGAGCAGGAGAAACTTAAAAGGCTAAAAGAAATAGCTGAGAATCAGGAAGCTAAGCTAAAAAAAGTGAGAGCACTTAAAGGCCACGTGGAACAGAAGAGACTAAGCAATGGGAAACTTGTGGAGGAAATTGAACAGATGAATAATTTGTTCCAGCAAAAACAGAGGGAGCTCGTCCTGGCTGTGTCAAAAGTAGAAGAACTGACCAGGCAGCTAGAGATGCTCAAGAACGGCAGGATCGACAGCCACCATGACAATCAGTCTGCAGTGGCTGAGCTTGATCGCCTCTATAAGGAGCTGCAGCTAAGAAACAAATTGAATCAAGAGCAGAATGCCAAGCTACAACAACAGAGGGAGTGTTTGAATAAGCGTAATTCAGAAGTGGCAGTCATGGATAAGCGTGTTAATGAGCTGAGGGACCGGCTGTGGAAGAAGAAGGCAGCTCTACAGCAAAAAGAAAATCTACCAGTTTCATCTGATGGAAATCTTCCCCAGCAAGCCGCGTCAGCCCCAAGCCGTGTGGCTGCAGTAGGTCCCTATATCCAGTCGTCTACTATGCCTCGGATGCCCTCAAGGCCTGAATTGCTGGTGAAGCCAGCCCTGCCGGATGGTTCCTTGGTCATTCAGGCTTCAGAGGGGCCGATGAAAATACAGACACTGCCCAACATGAGATCTGGGGCTGCTTCACAAACTAAAGGCTCTAAAATCCATCCAGTTGGCCCTGATTGGAGTCCTTCAAATGCAGATCTTTTCCCAAGCCAAGGCTCTGCTTCTGTACCTCAAAGCACTGGGAATGCTCTGGATCAAGTTGATGATGGAGAGGTTCCGCTGAGGGAGAAAGAGAAGAAAGTGCGTCCGTTCTCAATGTTTGATGCAGTAGACCAGTCCAATGCCCCACCTTCCTTTGGTACTCTGAGGAAGAACCAGAGCAGTGAAGATATCTTGCGGGATGCTCAGGTTGCAAATAAAAATGTGGCTAAAGTACCACCTCCTGTTCCTACAAAACCAAAACAGATTAATTTGCCTTATTTTGGACAAACTAATCAGCCACCTTCAGACATTAAGCCAGACGGAAGTTCTCAGCAGTTGTCAACAGTTGTTCCGTCCATGGGAACTAAACCAAAACCAGCAGGGCAGCAGCCGAGAGTGCTGCTATCTCCCAGCATACCTTCGGTTGGCCAAGACCAGACCCTTTCTCCAGGTTCTAAGCAAGAAAGTCCACCTGCTGCTGCCGTCCGGCCCTTTACTCCCCAGCCTTCCAAAGACACCTTACTTCCACCCTTCAGAAAACCCCAGACCGTGGCAGCAAGTTCAATATATTCCATGTATACGCAACAGCAGGCGCCAGGAAAAAACTTCCAGCAGGCTGTGCAGAGCGCGTTGACCAAGACTCATACCAGAGGGCCACACTTTTCAAGTGTATATGGTAAGCCTGTAATTGCTGCTGCCCAGAATCAACAGCAGCACCCAGAGAACATTTATTCCAATAGCCAGGGCAAGCCTGGCAGTCCAGAACCTGAAACAGAGCCTGTTTCTTCAGTTCAGGAGAACCATGAAAACGAAAGAATTCCTCGGCCACTCAGCCCAACTAAATTACTGCCTTTCTTATCTAATCCTTACCGAAACCAGAGTGATGCTGACCTAGAAGCCTTACGAAAGAAACTGTCTAACGCACCAAGGCCTCTAAAGAAACGTAGTTCTATTACAGAGCCAGAGGGTCCTAATGGGCCAAATATTCAGAAGCTTTTATATCAGAGGACCACCATAGCGGCCATGGAGACCATCTCTGTCCCATCATACCCATCCAAGTCAGCTTCTGTGACTGCCAGCTCAGAAAGCCCAGTAGAAATCCAGAATCCATATTTACATGTGGAGCCCGAAAAGGAGGTGGTCTCTCTGGTTCCTGAATCATTGTCCCCAGAGGATGTGGGGAATGCCAGTACAGAGAACAGTGACATGCCAGCTCCTTCTCCAGGCCTTGATTATGAGCCTGAGGGAGTCCCAGACAACAGCCCAAATCTCCAGAATAACCCAGAAGAACCAAATCCAGAGGCTCCACATGTGCTTGATGTGTACCTGGAGGAGTACCCTCCATACCCACCCCCACCATACCCATCTGGGGAGCCTGAAGGGCCCGGAGAAGACTCGGTGAGCATGCGCCCGCCTGAAATCACCGGGCAGGTCTCTCTGCCTCCTGGTAAAAGGACAAACTTGCGTAAAACTGGCTCAGAGCGTATCGCTCATGGAATGAGGGTGAAATTCAACCCCCTTGCTTTACTGCTAGATTCGTCTTTGGAGGGAGAATTTGACCTTGTACAGAGAATTATTTATGAGGTTGATGACCCAAGCCTCCCCAATGATGAAGGCATCACGGCTCTTCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAGTTCCTGGTACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAAGTGTGTAAGTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATGGAGGAAGGCTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGGGATTATGAACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAATGGTGGTGGGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGGGACTGTACCCAAGAATTAAACCAAGACAAAGGAGCTTGGCCTGA

Sequence Length

3147

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

25955664

NCBI GeneID

7159

Molecular Weight

126,323 Da

NCBI Official Full Name

Homo sapiens tumor protein p53 binding protein, 2, mRNA

NCBI Official Synonym Full Names

tumor protein p53 binding protein 2

NCBI Official Symbol

TP53BP2

NCBI Official Synonym Symbols

BBP; 53BP2; ASPP2; P53BP2; PPP1R13A

NCBI Protein Information

apoptosis-stimulating of p53 protein 2

UniProt Protein Name

Apoptosis-stimulating of p53 protein 2

Protein Family

Apoptosis-stimulating of p53 protein

UniProt Gene Name

TP53BP2

UniProt Synonym Gene Names

ASPP2; BBP; Bbp; 53BP2; p53-binding protein 2; p53BP2

UniProt Entry Name

ASPP2_HUMAN

NCBI Description

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3/SH2 adaptor activity

Biological Process: negative regulation of cell cycle; regulation of apoptosis; signal transduction

Research Articles on TP53BP2

1. ASSP2 expression is lower in cancerous tissues and decreased ASPP2 lead to higher cancer cells proliferation and autophagic flux, which contribute to the gemcitabine resistance.

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Product Notes

The TP53BP2 tp53bp2 (Catalog #AAA1278986) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAACGCCC CCCTGGCAGG GACATTGGTA GTGAGTGGAC CAAGATCTCA GGATCCAAGT TTAAAAAGAA ATGGTGTAAA AGTTCCTGGT GAATATCGAA GAAAGGAGAA CGGTGTTAAT AGTCCTAGGA TGGATCTGAC TCTTGCTGAA CTTCAGGAAA TGGCATCTCG CCAGCAGCAA CAGATTGAAG CCCAGCAACA ATTGCTGGCA ACTAAGGAAC AGCGCTTAAA GTTTTTGAAA CAACAAGATC AGCGACAACA GCAACAAGTT GCTGAGCAGG AGAAACTTAA AAGGCTAAAA GAAATAGCTG AGAATCAGGA AGCTAAGCTA AAAAAAGTGA GAGCACTTAA AGGCCACGTG GAACAGAAGA GACTAAGCAA TGGGAAACTT GTGGAGGAAA TTGAACAGAT GAATAATTTG TTCCAGCAAA AACAGAGGGA GCTCGTCCTG GCTGTGTCAA AAGTAGAAGA ACTGACCAGG CAGCTAGAGA TGCTCAAGAA CGGCAGGATC GACAGCCACC ATGACAATCA GTCTGCAGTG GCTGAGCTTG ATCGCCTCTA TAAGGAGCTG CAGCTAAGAA ACAAATTGAA TCAAGAGCAG AATGCCAAGC TACAACAACA GAGGGAGTGT TTGAATAAGC GTAATTCAGA AGTGGCAGTC ATGGATAAGC GTGTTAATGA GCTGAGGGAC CGGCTGTGGA AGAAGAAGGC AGCTCTACAG CAAAAAGAAA ATCTACCAGT TTCATCTGAT GGAAATCTTC CCCAGCAAGC CGCGTCAGCC CCAAGCCGTG TGGCTGCAGT AGGTCCCTAT ATCCAGTCGT CTACTATGCC TCGGATGCCC TCAAGGCCTG AATTGCTGGT GAAGCCAGCC CTGCCGGATG GTTCCTTGGT CATTCAGGCT TCAGAGGGGC CGATGAAAAT ACAGACACTG CCCAACATGA GATCTGGGGC TGCTTCACAA ACTAAAGGCT CTAAAATCCA TCCAGTTGGC CCTGATTGGA GTCCTTCAAA TGCAGATCTT TTCCCAAGCC AAGGCTCTGC TTCTGTACCT CAAAGCACTG GGAATGCTCT GGATCAAGTT GATGATGGAG AGGTTCCGCT GAGGGAGAAA GAGAAGAAAG TGCGTCCGTT CTCAATGTTT GATGCAGTAG ACCAGTCCAA TGCCCCACCT TCCTTTGGTA CTCTGAGGAA GAACCAGAGC AGTGAAGATA TCTTGCGGGA TGCTCAGGTT GCAAATAAAA ATGTGGCTAA AGTACCACCT CCTGTTCCTA CAAAACCAAA ACAGATTAAT TTGCCTTATT TTGGACAAAC TAATCAGCCA CCTTCAGACA TTAAGCCAGA CGGAAGTTCT CAGCAGTTGT CAACAGTTGT TCCGTCCATG GGAACTAAAC CAAAACCAGC AGGGCAGCAG CCGAGAGTGC TGCTATCTCC CAGCATACCT TCGGTTGGCC AAGACCAGAC CCTTTCTCCA GGTTCTAAGC AAGAAAGTCC ACCTGCTGCT GCCGTCCGGC CCTTTACTCC CCAGCCTTCC AAAGACACCT TACTTCCACC CTTCAGAAAA CCCCAGACCG TGGCAGCAAG TTCAATATAT TCCATGTATA CGCAACAGCA GGCGCCAGGA AAAAACTTCC AGCAGGCTGT GCAGAGCGCG TTGACCAAGA CTCATACCAG AGGGCCACAC TTTTCAAGTG TATATGGTAA GCCTGTAATT GCTGCTGCCC AGAATCAACA GCAGCACCCA GAGAACATTT ATTCCAATAG CCAGGGCAAG CCTGGCAGTC CAGAACCTGA AACAGAGCCT GTTTCTTCAG TTCAGGAGAA CCATGAAAAC GAAAGAATTC CTCGGCCACT CAGCCCAACT AAATTACTGC CTTTCTTATC TAATCCTTAC CGAAACCAGA GTGATGCTGA CCTAGAAGCC TTACGAAAGA AACTGTCTAA CGCACCAAGG CCTCTAAAGA AACGTAGTTC TATTACAGAG CCAGAGGGTC CTAATGGGCC AAATATTCAG AAGCTTTTAT ATCAGAGGAC CACCATAGCG GCCATGGAGA CCATCTCTGT CCCATCATAC CCATCCAAGT CAGCTTCTGT GACTGCCAGC TCAGAAAGCC CAGTAGAAAT CCAGAATCCA TATTTACATG TGGAGCCCGA AAAGGAGGTG GTCTCTCTGG TTCCTGAATC ATTGTCCCCA GAGGATGTGG GGAATGCCAG TACAGAGAAC AGTGACATGC CAGCTCCTTC TCCAGGCCTT GATTATGAGC CTGAGGGAGT CCCAGACAAC AGCCCAAATC TCCAGAATAA CCCAGAAGAA CCAAATCCAG AGGCTCCACA TGTGCTTGAT GTGTACCTGG AGGAGTACCC TCCATACCCA CCCCCACCAT ACCCATCTGG GGAGCCTGAA GGGCCCGGAG AAGACTCGGT GAGCATGCGC CCGCCTGAAA TCACCGGGCA GGTCTCTCTG CCTCCTGGTA AAAGGACAAA CTTGCGTAAA ACTGGCTCAG AGCGTATCGC TCATGGAATG AGGGTGAAAT TCAACCCCCT TGCTTTACTG CTAGATTCGT CTTTGGAGGG AGAATTTGAC CTTGTACAGA GAATTATTTA TGAGGTTGAT GACCCAAGCC TCCCCAATGA TGAAGGCATC ACGGCTCTTC ACAATGCTGT GTGTGCAGGC CACACAGAAA TCGTTAAGTT CCTGGTACAG TTTGGTGTAA ATGTAAATGC TGCTGATAGT GATGGATGGA CTCCATTACA TTGTGCTGCC TCATGTAACA ACGTCCAAGT GTGTAAGTTT TTGGTGGAGT CAGGAGCCGC TGTGTTTGCC ATGACCTACA GTGACATGCA GACTGCTGCA GATAAGTGCG AGGAAATGGA GGAAGGCTAC ACTCAGTGCT CCCAATTTCT TTATGGAGTT CAGGAGAAGA TGGGCATAAT GAATAAAGGA GTCATTTATG CGCTTTGGGA TTATGAACCT CAGAATGATG ATGAGCTGCC CATGAAAGAA GGAGACTGCA TGACAATCAT CCACAGGGAA GACGAAGATG AAATCGAATG GTGGTGGGCG CGCCTTAATG ATAAGGAGGG ATATGTTCCA CGTAACTTGC TGGGACTGTA CCCAAGAATT AAACCAAGAC AAAGGAGCTT GGCCTGA. It is sometimes possible for the material contained within the vial of "TP53BP2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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TP53BP2 cdna clone