TMEM59 cdna clone
TMEM59 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Description
TMEM59: Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Belongs to the TMEM59 family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: Golgi cis cisterna; Golgi medial cisterna; Golgi trans cisterna; late endosome; lysosome
Molecular Function: protein binding
Biological Process: positive regulation of autophagy
Research Articles on TMEM59
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Product Notes
The TMEM59 tmem59 (Catalog #AAA1266626) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggcgc cgaaggggag cctctgggtg aggacccaac tggggctccc gccgctgctg ctgctgacca tggccttggc cggaggttcg gggaccgctt cggctgaagc atttgactcg gtcttgggtg atacggcgtc ttgccaccgg gcctgtcagt tgacctaccc cttgcacacc taccctaagg aagaggagtt gtacgcatgt cagagaggtt gcaggctgtt ttcaatttgt cagtttgtgg atgatggaat tgacttaaat cgaactaaat tggaatgtga atctgcatgt acagaagcat attcccaatc tgatgagcaa tatgcttgcc atcttggttg ccagaatcag ctgccattcg ctgaactgag acaagaacaa cttatgtccc tgatgccaaa aatgcaccta ctctttcctc taactctggt gaggtcattc tggagtgaca tgatggactc cgcacagagc ttcataacct cttcatggac tttttatctt caagccgatg acggaaaaat agttatattc cagtctaagc cagaaatcca gtacgcacca catttggagc aggagcctac aaatttgaga gaatcatctc taagcaaaat gtcctcagat ctgcaaatga gaaattcaca agcgcacagg aattttcttg aagatggaga aagtgatggc tttttaagat gcctctctct taactctggg tggattttaa ctacaactct tgtcctctcg gtgatggtat tgctttggat ttgttgtgca actgttgcta cagctgtgga gcagtatgtt ccctctgaga agctgagtat ctatggtgac ttggagttta tgaatgaaca aaagctaaac agatatccag cttcttctct tgtggttgtt agatctaaaa ctgaagatca tgaagaagca gggcctctac ctacaaaagt gaatcttgct cattctgaaa tttaa. It is sometimes possible for the material contained within the vial of "TMEM59, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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