TEAD4 cdna clone
TEAD4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TEAD4: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12p13.3-p13.2
Cellular Component: nucleoplasm
Molecular Function: protein binding; transcription factor activity
Biological Process: muscle development; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; skeletal development; transcription initiation from RNA polymerase II promoter
Research Articles on TEAD4
Similar Products
Product Notes
The TEAD4 tead4 (Catalog #AAA1267011) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtatggtc ggaacgagct gattgcccgc tacatcaagc tccggacagg gaagacccgc accaggaagc aggtctccag ccacatccag gtgctggctc gtcgcaaagc tcgcgagatc caggccaagc taaaggacca ggcagctaag gacaaggccc tgcagagcat ggctgccatg tcgtctgcac agatcatctc cgccacggcc ttccacagta gcatggccct cgcccggggc cccggccgcc cagcagtctc agggttttgg caaggagctt tgccaggcca agccggaacg tcccatgatg tgaagccttt ctctcagcaa acctatgctg tccagcctcc gctgcctctg ccagggtttg agtctcctgc agggcccgcc ccatcgccct ctgcgccccc ggcaccccca tggcagggcc gcagcgtggc cagctccaag ctctggatgt tggagttctc tgccttcctg gagcagcagc aggacccgga cacgtacaac aagcacctgt tcgtgcacat tggccagtcc agcccaagct acagcgaccc ctacctcgaa gccgtggaca tccgccaaat ctatgacaaa ttcccggaga aaaagggtgg actcaaggat ctcttcgaac ggggaccctc caatgccttt tttcttgtga agttctgggc agacctcaac accaacatcg aggatgaagg cagctccttc tatggggtct ccagccagta tgagagcccc gagaacatga tcatcacctg ctccacgaag gtctgctctt tcggcaagca ggtggtggag aaagttgaga cagagtatgc tcgctatgag aatggacact actcttaccg catccaccgg tccccgctct gtgagtacat gatcaacttc atccacaagc tcaagcacct ccctgagaag tacatgatga acagcgtgct ggagaacttc accatcctgc aggtggtcac caacagagac acacaggaga ccttgctgtg cattgcctat gtctttgagg tgtcagccag tgagcacggg gctcagcacc acatctacag gctggtgaaa gaatga. It is sometimes possible for the material contained within the vial of "TEAD4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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