TDP2 cdna clone
TDP2
Translation Sequence: MELGSCLEGG REAAEEEGEP EVKKRRLLCV EFASVASCDA AVAQCFLAEN DWEMERALNSYFEPPVEESA LERRPETISE PKTYVDLTNE ETTDSTTSKI SPSEDTQQEN GSMFSLITWNIDGLDLNNLS ERARGVCSYL ALYSPDVIFL QEVIPPYYSY LKKRSSNYEI ITGHEEGYFTAIMLKKSRVK LKSQEIIPFP STKMMRNLLC VHVNVSGNEL CLMTSHLEST RGHAAERMNQLKMVLKKMQE APESATVIFA GDTNLRDREV TRCGGLPNNI VDVWEFLGKP KHCQYTWDTQMNSNLGITAA CKLRFDRIFF RAAAEEGHII PRSLDLLGLE KLDCGRFPSD HWGLLCNLDIIL
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Uniprot Description
TTRAP: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'- tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'- tyrosyl-DNA phosphodiesterase in cells. Also acts as a 5'-tyrosyl- RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA. Also acts as an adapter by participating to the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF- beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non- canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress. Belongs to the CCR4/nocturin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Inhibitor; EC 3.1.4.-
Chromosomal Location of Human Ortholog: 6p22.3-p22.1
Cellular Component: nucleoplasm; PML body; intercellular bridge; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; nuclease activity; manganese ion binding; magnesium ion binding; transcription corepressor activity; single-stranded DNA binding
Biological Process: cell surface receptor linked signal transduction; double-strand break repair
Research Articles on TDP2
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Product Notes
The TDP2 tdp2 (Catalog #AAA200897) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGGAGTTGG GGAGTTGCCT GGAGGGCGGG AGGGAGGCGG CGGAGGAAGA GGGCGAGCCT GAGGTGAAAA AGCGGCGACT TCTGTGTGTG GAGTTTGCCT CGGTCGCAAG CTGCGATGCC GCAGTGGCTC AGTGCTTCCT GGCCGAGAAC GACTGGGAGA TGGAAAGGGC TCTGAACTCC TACTTCGAGC CTCCGGTGGA GGAGAGCGCC TTGGAACGCC GACCTGAAAC CATCTCTGAG CCCAAGACCT ATGTTGACCT AACCAATGAA GAAACAACTG ATTCCACCAC TTCTAAAATC AGCCCATCTG AAGATACTCA GCAAGAAAAT GGCAGCATGT TCTCTCTCAT TACCTGGAAT ATTGATGGAT TAGATCTAAA CAATCTGTCA GAGAGGGCTC GAGGGGTGTG TTCCTACTTA GCTTTGTACA GCCCAGATGT GATATTTCTA CAGGAAGTTA TTCCCCCATA TTATAGCTAC CTAAAGAAGA GATCAAGTAA TTATGAGATT ATTACAGGTC ATGAAGAAGG ATATTTCACA GCTATAATGT TGAAGAAATC AAGAGTGAAA TTAAAAAGCC AAGAGATTAT TCCTTTTCCA AGTACCAAAA TGATGAGAAA CCTTTTATGT GTGCATGTGA ACGTGTCAGG AAATGAGCTT TGCCTTATGA CATCCCATTT GGAGAGCACC AGAGGGCATG CTGCGGAACG AATGAATCAG TTAAAAATGG TTTTAAAGAA AATGCAAGAG GCTCCAGAGT CAGCTACAGT TATATTTGCA GGAGATACAA ATCTAAGGGA TCGAGAGGTT ACCAGATGTG GTGGTTTACC CAACAACATT GTGGATGTCT GGGAGTTTTT GGGCAAACCT AAACATTGCC AGTATACATG GGATACACAA ATGAACTCTA ATCTTGGAAT AACTGCTGCT TGTAAACTTC GTTTTGATCG AATATTTTTC AGAGCAGCAG CAGAAGAGGG ACACATTATT CCCCGAAGTT TGGACCTTCT TGGATTAGAA AAACTGGACT GTGGTAGATT TCCTAGTGAT CACTGGGGTC TTCTGTGCAA CTTAGATATA ATATTGTAA< br> Tra nslation Sequence: MELGSCLEGG REAAEEEGEP EVKKRRLLCV EFASVASCDA AVAQCFLAEN DWEMERALNS YFEPPVEESA LERRPETISE PKTYVDLTNE ETTDSTTSKI SPSEDTQQEN GSMFSLITWN IDGLDLNNLS ERARGVCSYL ALYSPDVIFL QEVIPPYYSY LKKRSSNYEI ITGHEEGYFT AIMLKKSRVK LKSQEIIPFP STKMMRNLLC VHVNVSGNEL CLMTSHLEST RGHAAERMNQ LKMVLKKMQE APESATVIFA GDTNLRDREV TRCGGLPNNI VDVWEFLGKP KHCQYTWDTQ MNSNLGITAA CKLRFDRIFF RAAAEEGHII PRSLDLLGLE KLDCGRFPSD HWGLLCNLDI IL. It is sometimes possible for the material contained within the vial of "TDP2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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