TCEB2 cdna clone
TCEB2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
Uniprot Description
TCEB2: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Protein type: Transcription, coactivator/corepressor; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 16p12.3
Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytosol; nucleoplasm; VCB complex
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: protein complex assembly; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Research Articles on TCEB2
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Product Notes
The TCEB2 tceb2 (Catalog #AAA1276125) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggacgtgt tcctcatgat ccggcgccac aagaccacca tcttcacgga cgccaaggag tccagcacgg tgttcgaact gaagcgcatc gtcgagggca tcctcaagcg gcctcctgac gagcagcggc tgtacaagga tgaccaactc ttggatgatg gcaagacact gggcgagtgt ggcttcacca gtcaaacagc acggccacag gccccagcca cagtggggct ggccttccgg gcagatgaca cctttgaggc cctgtgcatc gagccgtttt ccagcccgcc agagctgccc gatgtgatga agccccagga ctcgggaagc agtgccaatg aacaagccgt gcagtga. It is sometimes possible for the material contained within the vial of "TCEB2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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