TBCD cdna clone
TBCD cDNA Clone
Gene Names
TBCD; tfcD; SSD-1
Synonyms
TBCD; TBCD cDNA Clone; TBCD cdna clone
Sequence
atggccctgagcgacgaaccggccgcgggtggccccgaggaggaggcggaggacgagacactggcctttggcgcggcgctggaagcgttcggcgagagcgcggagacccgggcgctgctgggccgcctgcgggaggtgcacggcggcggcgcggagcgcgaggtggccctggagcggttccgcgtaataatggacaaataccaggagcagcctcatctgttggacccgcaccttgaatggatgatgaacttgttgttggacatagtgcaagatcagacatctccagcttcccttgtacatctggcttttaaatttctttacatcatcaccaaggttcgaggctataaaacatttcttcgtttatttcctcatgaagttgccgatgtagagcctgttttagatttggtcacaattcagaatcccaaggaccatgaagcttgggaaacccgctacatgcttttgctctggctctccgtgacctgcctgatcccttttgatttttctcgccttgacgggaacctcctcacccagcctgggcaagcacgaatgtccataatggaccgtattctccaaatagcagagtcctacttgattgtcagtgacaaggcccgagatgcagctgctgtccttgtgtccagatttatcacacgtcctgatgtcaagcaaagcaagatggctgagttcctggactggagcctgtgcaatctggcccgttcctccttccagaccatgcagggggtcatcaccatggatgggacgctgcaggccctggcacaaatatttaaacatggaaaacgtgaagactgtttgccctatgctgccactgtcctcaggtgcctcgatggctgcagactccctgagagcaaccagaccctgctgcggaagctgggggtgaagcttgtgcagcgactggggctgacattcctgaagccgaaggtggcagcatggaggtaccagcgtggctgccgatctttggctgcaaatctgcagctcctcactcagggtcagagtgagcagaagccactcatcctgaccgaagatgacgacgaagatgacgacgtcccagagggggtggagcgtgtgatagagcagctgctggtcgggctgaaggacaaggacacggtcgtgcggtggtctgcagccaagggcatcggtaggatggctggcaggcttcccagagccctggcggatgatgtggtcgggtctgtgctggactgcttcagtttccaggagactgacaaggcgtggcatgggggatgtctggcgctggcagagctgggcaggagaggcctgttgctgccgtctcgactcgtggatgttgtcgccgtgatcctgaaggcgctgacctacgacgagaagcggggtgcctgcagcgtgggcaccaacgtcagggacgccgcctgctacgtgtgctgggccttcgcgcgtgcctatgagcctcaggagctgaagccctttgtgactgcaatctcgagtgcactggtgattgctgcggtgtttgaccgagacataaactgcagaagagcagcctctgccgccttccaggagaatgtggggagacagggcactttccctcatggtattgatattttgaccacagctgactattttgccgtcggtaacagatccaactgtttcctggttataagtgtgtttattgccggctttcctgagtacacgcagccaatgatagaccacctggttaccatgaagatcagccactgggatggggtcatccgagagttggctgcgagggcgctgcacaacctggcccagcaggcacccgagttcagcgccacgcaagtcttcccgaggctgctgtccatgacactgagtccagatcttcacatgaggcatgggtcgattctcgcctgcgcagaagttgcttacgccttgtacaaacttgcagcccaagagaacaggcccgtcacggaccatctggacgagcaggcagtgcagggcctgaagcagattcaccagcagctctatgatcgtcagttatacaggggtctgggaggacagctcatgagacaagcagtgtgtgttttaatagaaaagttgtcactttccaaaatgccctttagaggtgacaccgtaattgatggttggcaatggctgataaatgacactttgagacatctccatctcatctcaagtcactcccgccagcagatgaaggatgcagcagtctcggccctggctgctctatgcagtgaatattacatgaaggagccgggggaggcagatcccgcaattcaggaggagctgatcacgcagtacctggctgagcttcggaaccccgaggagatgactcgctgtggcttctcgttggccttgggcgcccttccaggcttccttctgaaaggccggctccagcaggttctcacaggtttaagagcagttacccacacttcccccgaggacgtaagttttgctgagtccaggagagacggcttgaaggccattgcgaggatttgccagactgttggtgtgaaagcaggagccccagacgaagctgtgtgcggagagaatgtttcccagatttactgtgcgctgctgggctgcatggacgactacaccacggacagcagaggggacgtgggcacctgggtccgcaaggccgccatgaccagtctgatggatctgacacttctgctggctcggagccagcctgagctgatcgaggcccatacctgtgagcgcatcatgtgctgtgtggcccagcaggccagtgagaagattgaccgtttccgtgctcacgccgccagcgtgttcctgacgctcctgcactttgacagccctcccatcccccacgtgccccaccgaggagaactggaaaagctgtttcccaggtccgatgtggcctccgtgaactggagtgcaccttcccaggccttcccacgcatcacccagctccttgggctgcccacctaccgctaccacgtcctgctggggctagtcgtgtccctgggcggcttgacggagtcgacgatccggcactccacccagagcctctttgagtacatgaagggcattcagagcgacccgcaggccctgggcagcttcagcgggacccttctgcagatctttgaggacaaccttctgaatgagagggtgtccgtgccgctgctgaagacgctggaccacgtgctcacccacggctgcttcgacatcttcaccacggaggaggaccacccctttgctgtgaagttgcttgcgctctgtaagaaagaaatcaagaattcaaaagatatccagaagctcctgtcaggcatcgcagtgttctgcgggatggtgcagttccccggcgacgtgaggaggcaggccctcctgcagctgtgtctgctcctctgccaccgtttcccgctgatccggaagaccacggccagccaggtgtacgagacattgctcacctacagtgacgtcgtgggcgcggatgtgctggacgaggtggtgactgtgctcagtgacactgcgtgggacgcggagcttgcagtggtgagagagcagcgcaaccgtctgtgtgaccttctgggcgtacccaggccccagctggtgccccagcctggtgcctgctga
Sequence Length
3579
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
84,263 Da
NCBI Official Full Name
Homo sapiens tubulin folding cofactor D, mRNA
NCBI Official Synonym Full Names
tubulin folding cofactor D
NCBI Official Symbol
TBCD
NCBI Official Synonym Symbols
tfcD; SSD-1
NCBI Protein Information
tubulin-specific chaperone D
UniProt Protein Name
Tubulin-specific chaperone D
Protein Family
UniProt Gene Name
TBCD
UniProt Synonym Gene Names
KIAA0988; SSD1; TFCD; tfcD
UniProt Entry Name
TBCD_HUMAN
NCBI Description
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Uniprot Description
TBCD: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase- activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Belongs to the TBCD family. 5 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: adherens junction; lateral plasma membrane; microtubule; tight junction
Molecular Function: beta-tubulin binding; chaperone binding; GTPase activator activity; protein binding
Biological Process: negative regulation of microtubule polymerization; post-chaperonin tubulin folding pathway; protein folding; tubulin folding
Research Articles on TBCD
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Product Notes
The TBCD tbcd (Catalog #AAA1277773) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccctga gcgacgaacc ggccgcgggt ggccccgagg aggaggcgga ggacgagaca ctggcctttg gcgcggcgct ggaagcgttc ggcgagagcg cggagacccg ggcgctgctg ggccgcctgc gggaggtgca cggcggcggc gcggagcgcg aggtggccct ggagcggttc cgcgtaataa tggacaaata ccaggagcag cctcatctgt tggacccgca ccttgaatgg atgatgaact tgttgttgga catagtgcaa gatcagacat ctccagcttc ccttgtacat ctggctttta aatttcttta catcatcacc aaggttcgag gctataaaac atttcttcgt ttatttcctc atgaagttgc cgatgtagag cctgttttag atttggtcac aattcagaat cccaaggacc atgaagcttg ggaaacccgc tacatgcttt tgctctggct ctccgtgacc tgcctgatcc cttttgattt ttctcgcctt gacgggaacc tcctcaccca gcctgggcaa gcacgaatgt ccataatgga ccgtattctc caaatagcag agtcctactt gattgtcagt gacaaggccc gagatgcagc tgctgtcctt gtgtccagat ttatcacacg tcctgatgtc aagcaaagca agatggctga gttcctggac tggagcctgt gcaatctggc ccgttcctcc ttccagacca tgcagggggt catcaccatg gatgggacgc tgcaggccct ggcacaaata tttaaacatg gaaaacgtga agactgtttg ccctatgctg ccactgtcct caggtgcctc gatggctgca gactccctga gagcaaccag accctgctgc ggaagctggg ggtgaagctt gtgcagcgac tggggctgac attcctgaag ccgaaggtgg cagcatggag gtaccagcgt ggctgccgat ctttggctgc aaatctgcag ctcctcactc agggtcagag tgagcagaag ccactcatcc tgaccgaaga tgacgacgaa gatgacgacg tcccagaggg ggtggagcgt gtgatagagc agctgctggt cgggctgaag gacaaggaca cggtcgtgcg gtggtctgca gccaagggca tcggtaggat ggctggcagg cttcccagag ccctggcgga tgatgtggtc gggtctgtgc tggactgctt cagtttccag gagactgaca aggcgtggca tgggggatgt ctggcgctgg cagagctggg caggagaggc ctgttgctgc cgtctcgact cgtggatgtt gtcgccgtga tcctgaaggc gctgacctac gacgagaagc ggggtgcctg cagcgtgggc accaacgtca gggacgccgc ctgctacgtg tgctgggcct tcgcgcgtgc ctatgagcct caggagctga agccctttgt gactgcaatc tcgagtgcac tggtgattgc tgcggtgttt gaccgagaca taaactgcag aagagcagcc tctgccgcct tccaggagaa tgtggggaga cagggcactt tccctcatgg tattgatatt ttgaccacag ctgactattt tgccgtcggt aacagatcca actgtttcct ggttataagt gtgtttattg ccggctttcc tgagtacacg cagccaatga tagaccacct ggttaccatg aagatcagcc actgggatgg ggtcatccga gagttggctg cgagggcgct gcacaacctg gcccagcagg cacccgagtt cagcgccacg caagtcttcc cgaggctgct gtccatgaca ctgagtccag atcttcacat gaggcatggg tcgattctcg cctgcgcaga agttgcttac gccttgtaca aacttgcagc ccaagagaac aggcccgtca cggaccatct ggacgagcag gcagtgcagg gcctgaagca gattcaccag cagctctatg atcgtcagtt atacaggggt ctgggaggac agctcatgag acaagcagtg tgtgttttaa tagaaaagtt gtcactttcc aaaatgccct ttagaggtga caccgtaatt gatggttggc aatggctgat aaatgacact ttgagacatc tccatctcat ctcaagtcac tcccgccagc agatgaagga tgcagcagtc tcggccctgg ctgctctatg cagtgaatat tacatgaagg agccggggga ggcagatccc gcaattcagg aggagctgat cacgcagtac ctggctgagc ttcggaaccc cgaggagatg actcgctgtg gcttctcgtt ggccttgggc gcccttccag gcttccttct gaaaggccgg ctccagcagg ttctcacagg tttaagagca gttacccaca cttcccccga ggacgtaagt tttgctgagt ccaggagaga cggcttgaag gccattgcga ggatttgcca gactgttggt gtgaaagcag gagccccaga cgaagctgtg tgcggagaga atgtttccca gatttactgt gcgctgctgg gctgcatgga cgactacacc acggacagca gaggggacgt gggcacctgg gtccgcaagg ccgccatgac cagtctgatg gatctgacac ttctgctggc tcggagccag cctgagctga tcgaggccca tacctgtgag cgcatcatgt gctgtgtggc ccagcaggcc agtgagaaga ttgaccgttt ccgtgctcac gccgccagcg tgttcctgac gctcctgcac tttgacagcc ctcccatccc ccacgtgccc caccgaggag aactggaaaa gctgtttccc aggtccgatg tggcctccgt gaactggagt gcaccttccc aggccttccc acgcatcacc cagctccttg ggctgcccac ctaccgctac cacgtcctgc tggggctagt cgtgtccctg ggcggcttga cggagtcgac gatccggcac tccacccaga gcctctttga gtacatgaag ggcattcaga gcgacccgca ggccctgggc agcttcagcg ggacccttct gcagatcttt gaggacaacc ttctgaatga gagggtgtcc gtgccgctgc tgaagacgct ggaccacgtg ctcacccacg gctgcttcga catcttcacc acggaggagg accacccctt tgctgtgaag ttgcttgcgc tctgtaagaa agaaatcaag aattcaaaag atatccagaa gctcctgtca ggcatcgcag tgttctgcgg gatggtgcag ttccccggcg acgtgaggag gcaggccctc ctgcagctgt gtctgctcct ctgccaccgt ttcccgctga tccggaagac cacggccagc caggtgtacg agacattgct cacctacagt gacgtcgtgg gcgcggatgt gctggacgag gtggtgactg tgctcagtga cactgcgtgg gacgcggagc ttgcagtggt gagagagcag cgcaaccgtc tgtgtgacct tctgggcgta cccaggcccc agctggtgcc ccagcctggt gcctgctga. It is sometimes possible for the material contained within the vial of "TBCD, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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