TANK cdna clone
TANK cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Description
TANK: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: cytoplasm; cytosol; protein complex
Molecular Function: protein binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; negative regulation of I-kappaB kinase/NF-kappaB cascade; response to DNA damage stimulus; signal transduction
Research Articles on TANK
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Product Notes
The TANK tank (Catalog #AAA1270192) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggataaaa acattggcga gcaactcaat aaagcgtatg aagccttccg gcaggcatgc atggatagag attctgcagt aaaagaatta cagcaaaaga ctgagaacta tgagcagaga atacgtgaac aacaggaaca gctgtcactt caacagacta ttattgacaa gctaaaatct cagttacttc ttgtgaattc cactcaagat aacaattatg gctgtgttcc tctgcttgaa gacagtgaaa caagaaagaa taatttgact cttgatcagc cacaagataa agtgatttca ggaatagcaa gagaaaaact accaaaggta agaagacaag aggtttcttc tcctagaaaa gaaacttcag caaggagtct tggcagtcct ttgctccatg aaaggggtaa tatagagaag actttctggg atctgaaaga agaatttcat aaaatatgca tgctagcaaa agcacagaaa gaccacttaa gcaaacttaa tataccagac actgcaactg aaacacagtg ctctgtgcct atacagtgta cggataaaac agataaacaa gaagcgctgt ttaagcctca ggctaaagat gatataaata gaggtgcacc atccatcaca tctgtcacac caagaggact gtgcagagat gaggaagaca cctcttttga atcactttct aaattcaatg tcaagtttcc acctatggac aatgactcaa ctttcttaca tagcactcca gagagacccg gcatccttag tcctgccacg tctgaggtag tgtgccaaga gaaatttaat atggagttca gagacaaccc agggaacttt gttaaaacag aagaaacttt atttgaaatt cagggaattg accccatagc ttcagctata caaaacctta aaacaactga caaaacaaag ccctcaaatc tcgtaaacac ttgtatcagg acaactctgg atagagctgc gtgtttgcca cctggagacc ataatgcatt atatgtaaat agcttcccac ttctggaccc atctgatgca ccttttccct cactcgattc cccgggaaaa gcaatccgag gaccacagca gcccatttgg aagccctttc ctaatcaaga cagtgactcg gtggtactaa gtggcacaga ctcagaactg catatacctc gagtatgtga attctgtcaa gcagttttcc caccatccat tacatccagg ggggatttcc ttcggcatct taattcacac ttcaatggag agacttaa. It is sometimes possible for the material contained within the vial of "TANK, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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