SYVN1 cdna clone
SYVN1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]
Uniprot Description
SYVN1: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin conjugating system; Membrane protein, multi-pass; Ubiquitin ligase; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleoplasm; smooth endoplasmic reticulum
Molecular Function: ATPase binding; chaperone binding; protein binding; unfolded protein binding
Biological Process: ER-associated protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein stabilization; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; retrograde protein transport, ER to cytosol; unfolded protein response
Research Articles on SYVN1
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Product Notes
The SYVN1 syvn1 (Catalog #AAA1270951) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgttccgca cggcagtgat gatggcggcc agcctggcgc tgaccggggc tgtggtggct cacgcctact acctcaaaca ccagttctac cccactgtgg tgtacctgac caagtccagc cccagcatgg cagtcctgta catccaggcc tttgtccttg tcttccttct gggcaaggtg atgggcaagg tgttctttgg gcaactgagg gcagcagaga tggagcacct tctggaacgt tcctggtacg ccgtcacaga gacttgtctg gccttcaccg tttttcggga tgacttcagc ccccgctttg ttgcactctt cactcttctt ctcttcctca aatgtttcca ctggctggct gaggaccgtg tggactttat ggaacgcagc cccaacatct cctggctctt tcactgccgc attgtctctc ttatgttcct cctgggcatc ctggacttcc tcttcgtcag ccacgcctat cacagcatcc tgacccgtgg ggcctctgtg cagctggtgt ttggctttga gtatgccatc ctgatgacga tggtgctcac catcttcatc aagtatgtgc tgcactccgt ggacctccag agtgagaacc cctgggacaa caaggctgtg tacatgctct acacagagct gtttacaggc ttcatcaagg ttctgctgta catggccttc atgaccatca tgatcaaggt gcacaccttc ccactctttg ccatccggcc catgtacctg gccatgagac agttcaagaa agctgtgaca gatgccatca tgtctcgccg agccatccgc aacatgaaca ccctgtatcc agatgccacc ccagaggagc tccaggcaat ggacaatgtc tgcatcatct gccgagaaga gatggtgact ggtgccaaga gactgccctg caaccacatt ttccatacca gctgcctgcg ctcctggttc cagcggcagc agacctgccc cacctgccgt atggatgtcc ttcgtgcatc gctgccagcg cagtcaccac cacccccgga gcctgcggat caggggccac cccctgcccc ccacccccca ccactcttgc ctcagccccc caacttcccc cagggcctcc tgcctccttt tcctccaggc atgttcccac tgtggccccc catgggcccc tttccacctg tcccgcctcc ccccagctca ggagaggctg tggctcctcc atccaccagt gcagcagccc tttctcggcc cagtggagca gctacaacca cagctgctgg caccagtgct actgctgctt ctgccacagc atctggccca ggctctggct ctgccccaga ggctggccct gcccctggtt tccccttccc tcctccctgg atgggtatgc ccctgcctcc accctttgcc ttccccccaa tgcctgtgcc ccctgcgggc tttgctgggc tgaccccaga ggagctacga gctctggagg gccatgagcg gcagcacctg gaggcccggc tgcagagcct gcgtaacatc cacacactgc tggacgccgc catgctgcag atcaaccagt acctcaccgt gctggcctcc ttggggcccc cccggcctgc cacttcagtc aactccactg aggagactgc cactacagtt gttgctgctg cctcctccac cagcatccct agctcagagg ccacgacccc aaccccagga gcctccccac cagcccctga aatggaaagg cctccagctc ctgagtcagt gggcacagag gagatgcctg aggatggaga gcccgatgca gcagagctcc gccggcgccg cctgcagaag ctggagtctc ctgttgccca ctga. It is sometimes possible for the material contained within the vial of "SYVN1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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