SPINT1 cdna clone

SPINT1 cDNA Clone

Gene Names

SPINT1; HAI; HAI1; MANSC2

Synonyms

SPINT1; SPINT1 cDNA Clone; SPINT1 cdna clone

Ordering
Cat. Num. AAA1272699 For Research Use Only!

Sequence

atggcccctgcgaggacgatggcccgcgcccgcctcgccccggccggcatccctgccgtcgccttgtggcttctgtgcacgctcggcctccagggcacccaggccgggccaccgcccgcgccccctgggctgcccgcgggagccgactgcctgaacagctttaccgccggggtgcctggcttcgtgctggacaccaacgcctcggtcagcaacggagctaccttcctggagtcccccaccgtgcgccggggctgggactgcgtgcgcgcctgctgcaccacccagaactgcaacttggcgctagtggagctgcagcccgaccgcggggaggacgccatcgccgcctgcttcctcatcaactgcctctacgagcagaacttcgtgtgcaagttcgcgcccagggagggcttcatcaactacctcacgagggaagtgtaccgctcctaccgccagctgcggacccagggctttggagggtctgggatccccaaggcctgggcaggcatagacttgaaggtacaaccccaggaacccctggtgctgaaggatgtggaaaacacagattggcgcctactgcggggtgacacggatgtcagggtagagaggaaagacccaaaccaggtggaactgtggggactcaaggaaggcacctacctgttccagctgacagtgactagctcagaccacccagaggacacggccaacgtcacagtcactgtgctgtccaccaagcagacagaagactactgcctcgcatccaacaaggtgggtcgctgccggggctctttcccacgctggtactatgaccccacggagcagatctgcaagagtttcgtttatggaggctgcttgggcaacaagaacaactaccttcgggaagaagagtgcattctagcctgtcggggtgtgcaaggcccctccatggaaaggcgccatccagtgtgctctggcacctgtcagcccacccagttccgctgcagcaatggctgctgcatcgacagtttcctggagtgtgacgacacccccaactgccccgacgcctccgacgaggctgcctgtgaaaaatacacgagtggctttgacgagctccagcgcatccatttccccagtgacaaagggcactgcgtggacctgccagacacaggactctgcaaggagagcatcccgcgctggtactacaaccccttcagcgaacactgcgcccgctttacctatggtggttgttatggcaacaagaacaactttgaggaagagcagcagtgcctcgagtcttgtcgcggcatctccaagaaggatgtgtttggcctgaggcgggaaatccccattcccagcacaggctctgtggagatggctgtcgcagtgttcctggtcatctgcattgtggtggtggtagccatcttgggttactgcttcttcaagaaccagagaaaggacttccacggacaccaccaccacccaccacccacccctgccagctccactgtctccactaccgaggacacggagcacctggtctataaccacaccacccggcccctctga

Sequence Length

1542

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

13278722

NCBI GeneID

6692

Molecular Weight

56,885 Da

NCBI Official Full Name

Homo sapiens serine peptidase inhibitor, Kunitz type 1, mRNA

NCBI Official Synonym Full Names

serine peptidase inhibitor, Kunitz type 1

NCBI Official Symbol

SPINT1

NCBI Official Synonym Symbols

HAI; HAI1; MANSC2

NCBI Protein Information

kunitz-type protease inhibitor 1

UniProt Protein Name

Kunitz-type protease inhibitor 1

Protein Family

Kunitz-type protease inhibitor

UniProt Gene Name

SPINT1

UniProt Synonym Gene Names

HAI1; HAI-1

UniProt Entry Name

SPIT1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

SPINT1: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: extracellular region; extracellular space; membrane

Research Articles on SPINT1

1. The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF/MET signalling and epithelial cohesion

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Product Notes

The SPINT1 spint1 (Catalog #AAA1272699) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcccctg cgaggacgat ggcccgcgcc cgcctcgccc cggccggcat ccctgccgtc gccttgtggc ttctgtgcac gctcggcctc cagggcaccc aggccgggcc accgcccgcg ccccctgggc tgcccgcggg agccgactgc ctgaacagct ttaccgccgg ggtgcctggc ttcgtgctgg acaccaacgc ctcggtcagc aacggagcta ccttcctgga gtcccccacc gtgcgccggg gctgggactg cgtgcgcgcc tgctgcacca cccagaactg caacttggcg ctagtggagc tgcagcccga ccgcggggag gacgccatcg ccgcctgctt cctcatcaac tgcctctacg agcagaactt cgtgtgcaag ttcgcgccca gggagggctt catcaactac ctcacgaggg aagtgtaccg ctcctaccgc cagctgcgga cccagggctt tggagggtct gggatcccca aggcctgggc aggcatagac ttgaaggtac aaccccagga acccctggtg ctgaaggatg tggaaaacac agattggcgc ctactgcggg gtgacacgga tgtcagggta gagaggaaag acccaaacca ggtggaactg tggggactca aggaaggcac ctacctgttc cagctgacag tgactagctc agaccaccca gaggacacgg ccaacgtcac agtcactgtg ctgtccacca agcagacaga agactactgc ctcgcatcca acaaggtggg tcgctgccgg ggctctttcc cacgctggta ctatgacccc acggagcaga tctgcaagag tttcgtttat ggaggctgct tgggcaacaa gaacaactac cttcgggaag aagagtgcat tctagcctgt cggggtgtgc aaggcccctc catggaaagg cgccatccag tgtgctctgg cacctgtcag cccacccagt tccgctgcag caatggctgc tgcatcgaca gtttcctgga gtgtgacgac acccccaact gccccgacgc ctccgacgag gctgcctgtg aaaaatacac gagtggcttt gacgagctcc agcgcatcca tttccccagt gacaaagggc actgcgtgga cctgccagac acaggactct gcaaggagag catcccgcgc tggtactaca accccttcag cgaacactgc gcccgcttta cctatggtgg ttgttatggc aacaagaaca actttgagga agagcagcag tgcctcgagt cttgtcgcgg catctccaag aaggatgtgt ttggcctgag gcgggaaatc cccattccca gcacaggctc tgtggagatg gctgtcgcag tgttcctggt catctgcatt gtggtggtgg tagccatctt gggttactgc ttcttcaaga accagagaaa ggacttccac ggacaccacc accacccacc acccacccct gccagctcca ctgtctccac taccgaggac acggagcacc tggtctataa ccacaccacc cggcccctct ga. It is sometimes possible for the material contained within the vial of "SPINT1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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SPINT1 cdna clone