SPAM1 cdna clone
SPAM1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Description
SPAM1: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Belongs to the glycosyl hydrolase 56 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Cell surface; EC 3.2.1.35; Hydrolase; Glycan Metabolism - glycosaminoglycan degradation
Chromosomal Location of Human Ortholog: 7q31.3
Cellular Component: plasma membrane
Biological Process: binding of sperm to zona pellucida; sperm-egg recognition
Research Articles on SPAM1
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Product Notes
The SPAM1 spam1 (Catalog #AAA1275585) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggagtgc taaaattcaa gcacatcttt ttcagaagct ttgttaaatc aagtggagta tcccagatag ttttcacctt ccttctgatt ccatgttgct tgactctgaa tttcagagca cctcctgtta ttccaaatgt gcctttcctc tgggcctgga atgccccaag tgaattttgt cttggaaaat ttgatgagcc actagatatg agcctcttct ctttcatagg aagcccccga ataaacgcca ccgggcaagg tgttacaata ttttatgttg atagacttgg ctactatcct tacatagatt caatcacagg agtaactgtg aatggaggaa tcccccagaa gatttcctta caagaccatc tggacaaagc taagaaagac attacatttt atatgccagt agacaatttg ggaatggctg ttattgactg ggaagaatgg agacccactt gggcaagaaa ctggaaacct aaagatgttt acaagaatag gtctattgaa ttggttcagc aacaaaatgt acaacttagt ctcacagagg ccactgagaa agcaaaacaa gaatttgaaa aagcagggaa ggatttcctg gtagagacta taaaattggg aaaattactt cggccaaatc acttgtgggg ttattatctt tttccggatt gttacaacca tcactataag aaacccggtt acaatggaag ttgcttcaat gtagaaataa aaagaaatga tgatctcagc tggttgtgga atgaaagcac tgctctttac ccatccattt atttgaacac tcagcagtct cctgtagctg ctacactcta tgtgcgcaat cgagttcggg aagccatcag agtttccaaa atacctgatg caaaaagtcc acttccggtt tttgcatata cccgcatagt ttttactgat caagttttga aattcctttc tcaagatgaa cttgtgtata catttggcga aactgttgct ctgggtgctt ctggaattgt aatatgggga accctcagta taatgcgaag tatgaaatct tgcttgctcc tagacaatta catggagact atactgaatc cttacataat caacgtcaca ctagcagcca aaatgtgtag ccaagtgctt tgccaggagc aaggagtgtg tataaggaaa aactggaatt caagtgacta tcttcacctc aacccagata attttgctat tcaacttgag aaaggtggaa agttcacagt acgtggaaaa ccgacacttg aagacctgga gcaattttct gaaaaatttt attgcagctg ttatagcacc ttgagttgta aggagaaagc tgatgtaaaa gacactgatg ctgttgatgt gtgtattgct gatggtgtct gtatagatgc ttttctaaaa cctcccatgg agacagaaga acctcaaatt ttctacaatg cttcaccctc cacactatct gccacaatgt tcatttggag gctggaagtc tgggatcaag gtattagcag aattggtttc ttctga. It is sometimes possible for the material contained within the vial of "SPAM1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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