NCBI Description
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhesion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.
Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cell adhesion; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: cytosol; focal adhesion
Molecular Function: protein binding; structural constituent of cytoskeleton; vinculin binding
Biological Process: cell adhesion; muscle contraction; positive regulation of stress fiber formation
Product Notes
The SORBS3 sorbs3 (Catalog #
AAA1273058) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctgatg gaggaagccc cttcctaggt cggagggact ttgtctaccc ttcctcaacc cgagacccta gtgcctctaa cggagggggc agcccagcca ggagggaaga gaagaagaga aaggccgcca ggctcaagtt tgacttccag gcgcagtccc ccaaggagct gactctgcag aagggtgaca ttgtctacat ccacaaggag gtggacaaga actggctgga gggagagcac cacggccgcc tgggcatctt ccctgctaat tatgtggagg tgctgcccgc agatgagatc cctaagccca tcaagccccc gacctaccag gtgctggagt atggagaggc tgtggcccag tacaccttca agggggacct ggaggtggag ctgtccttcc gcaagggaga gcacatctgc ctgatccgca aggtgaacga gaactggtac gagggacgca tcacgggcac ggggcgccaa ggcatattcc ctgccagcta cgtgcaggtg tctcgtgaac cccggctccg gctctgtgac gacggccccc agctccccac gtctccccgc ctgaccgctg ccgcccgctc agcccgtcac cccagctccc cctcagccct gcgcagccca gctgacccca tcgacttggg gggacagacc tccccccgtc gcactggctt ctccttcccc acccaggagc ctagacccca gacccagaat cttggcaccc ctggtccagc tctgtcccac tctcgaggtc ccagccatcc cctggacctg gggacctcct ctcctaacac ctctcagata cactggaccc cgtaccgggc gatgtaccag tacaggcccc agaacgaaga cgagctggag ctgcgcgagg gggacagggt ggatgtcatg cagcagtgtg acgatggctg gtttgtgggt gtctcccgga ggacccagaa attcggaacg ttccctggaa attacgttgc cccggtgtga.
It is sometimes possible for the material contained within the vial of
"SORBS3, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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