SORBS3 cdna clone
SORBS3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhesion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.
Protein type: Cell adhesion; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: cytosol; focal adhesion
Molecular Function: protein binding; structural constituent of cytoskeleton; vinculin binding
Biological Process: cell adhesion; muscle contraction; positive regulation of stress fiber formation
Research Articles on SORBS3
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Product Notes
The SORBS3 sorbs3 (Catalog #AAA1270618) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCAGGGCC CACCCCGCAG CCTCCGCGCT GGGCTCAGCC TGGACGACTT CATCCCTGGC CACCTCCAGT CCCACATAGG GTCTTCCTCC CGGGGGACAC GGGTGCCCGT GATCCGGAAT GGTGGCTCCA ACACCCTTAA TTTCCAGTTC CACGACCCCG CGCCCAGGAC TGTGTGCAAT GGGGGCTACA CACCAAGACG AGATGCTTCC CAGCACCCGG ACCCTGCGTG GTATCAGACC TGGCCAGGCC CTGGGAGCAA GCCCTCTGCA AGCACAAAGA TCCCTGCCTC CCAGCACACC CAGAACTGGT CAGCCACGTG GACCAAGGAC AGCAAGCGTC GGGACAAGCG CTGGGTCAAG TACGAGGGAA TCGGGCCCGT GGACGAGAGC GGCATGCCCA TTGCCCCCCG ATCCAGCGTT GACAGACCCA GAGACTGGTA CCGGAGAATG TTCCAGCAGA TTCACCGGAA AATGCCAGAC TTGCAGCTGG ACTGGACCTT CGAGGAGCCA CCCAGAGACC CCAGGCATCT AGGAGCCCAG CAAAGACCTG CCCACAGGCC CGGCCCGGCA ACATCTTCCA GTGGAAGAAG CTGGGACCAC TCTGAAGAGT TACCTAGAAG CACCTTCAAC TACAGACCTG GAGCATTCTC CACTGTGCTG CAGCCCTCAA ATCAGGTGCT CAGACGCCGG GAAAAAGTAG ACAATGTCTG GACGGAAGAG TCCTGGAACC AGTTTCTGCA GGAACTAGAG ACTGGGCAGA GGCCCAAGAA ACCGCTGGTG GACGACCCTG GTGAGAAGCC CTCCCAGCCC ATTGAGGTGC TGCTGGAGAG AGAGCTGGCC GAGCTGAGCG CCGAGCTGGA CAAGGACCTG CGGGCAATTG AGACCCGACT GCCGTCCCCC AAGAGCTCGC CGGCGCCCCG ACGGGCCCCG GAGCAGCGGC CCCCGGCCGG CCCGGCCTCA GCCTGGAGCT CCAGCTACCC ACATGCACCT TACCTGGGTT CCGCCCGGTC CCTGAGTCCC CACAAAATGG CTGATGGAGG AAGCCCCTTC CTAGGTCGGA GGGACTTTGT CTACCCTTCC TCAACCCGAG ACCCTAGTGC CTCTAACGGA GGGGGCAGCC CAGCCAGGAG GGAAGAGAAG AAGAGAAAGG CCGCCAGGCT CAAGTTTGAC TTCCAGGCGC AGTCCCCCAA GGAGCTGACT CTGCAGAAGG GTGACATTGT CTACATCCAC AAGGAGGTGG ACAAGAACTG GCTGGAGGGA GAGCACCACG GCCGCCTGGG CATCTTCCCT GCTAATTATG TGGAGGTGCT GCCCGCAGAT GAGATCCCTA AGCCCATCAA GCCCCCGACC TACCAGGTGC TGGAGTATGG AGAGGCTGTG GCCCAGTACA CCTTCAAGGG GGACCTGGAG GTGGAGCTGT CCTTCCGCAA GGGAGAGCAC ATCTGCCTGA TCCGCAAGGT GAACGAGAAC TGGTACGAGG GACGCATCAC GGGCACGGGG CGCCAAGGCA TATTCCCTGC CAGCTACGTG CAGGTGTCTC GTGAACCCCG GCTCCGGCTC TGTGACGACG GCCCCCAGCT CCCCACGTCT CCCCGCCTGA CCGCTGCCGC CCGCTCAGCC CGTCACCCCA GCTCCCCCTC AGCCCTGCGC AGCCCAGCTG ACCCCACCGA CTTGGGGGGA CAGACCTCCC CCCGTCGCAC TGGCTTCTCC TTCCCCACCC AGGAGCCTAG ACCCCAGACC CAGAATCTTG GCACCCCTGG TCCAGCTCTG TCCCACTCTC GAGGTCCCAG CCATCCCCTG GACCTGGGGA CCTCCTCTCC TAACACCTCT CAGATACACT GGACCCCGTA CCGGGCGATG TACCAGTACA GGCCCCAGAA CGAAGACGAG CTGGAGCTGC GCGAGGGGGA CAGGGTGGAT GTCATGCAGC AGTGTGACGA TGGCTGGTTT GTGGGTGTCT CCCGGAGGAC CCAGAAATTC GGAACGTTCC CTGGAAATTA CGTTGCCCCG GTGTGA. It is sometimes possible for the material contained within the vial of "SORBS3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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