Structure
Amentoflavone, Inhibitor
Amentoflavone
Purity
>98% (HPLC)
Synonyms
Amentoflavone; Didemethyl Ginkgetin; NSC 295677; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone
Target
COX
Receptor
COX; COX-2; kappa-opioid receptor; CYP2C9; CYP3A4; PLA2
Chemical Name
8-[5-(5, 7-Dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5, 7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
SMILES
O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3C4=CC(C5=CC(C6=C(O5)C=C(O)C=C6O)=O)=CC=C4O
Molecular Formula
C30H18O10
CAS Number
1617-53-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Amentoflavone, inhibitor
Amentoflavone can interact with many other medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are proteins used for drug metabolism in the body, is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted supression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
Product Categories/Family for Amentoflavone, inhibitor
References
1. Sakthivel KM, et al. Int Immunopharmacol. 2013 Nov; 17 (3):907-16.
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Product Notes
The Amentoflavone (Catalog #AAA3602366) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Amentoflavone, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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