SMG7 cdna clone
SMG7 cDNA Clone
Gene Names
SMG7; EST1C; SGA56M; C1orf16
Synonyms
SMG7; SMG7 cDNA Clone; SMG7 cdna clone
Sequence
atgagcctgcagagcgcgcagtacctccggcaggcagaagtcctgaaggctgacatgacagattctaagctgggtccagctgaagtctggacatccaggcaggctctgcaggacctgtaccagaaaatgctagttaccgatttggaatacgctttagacaagaaagtagaacaggatctctggaatcacgcctttaagaatcagatcacaacactacaaggccaggcaaagaatcgagcaaatccgaatcggagtgaagttcaggcaaacctttctctgttcctagaggcagctagtggcttctatactcagttattacaagaactgtgtacagtatttaatgtagatttaccatgccgtgtgaagtcttcccaattgggaattatcagcaataaacagacgcataccagcgccatagtgaagccacagtctagctcctgttcctatatctgccagcactgcctcgtccaccttggagacattgctcgatacagaaaccagaccagccaggcagagtcctactataggcatgcagctcagcttgtcccctccaatggtcagccttataatcagttggctatcttagcttcttccaaaggagaccatctgaccacaattttctactactgcagaagcattgctgtgaagttccctttcccagctgcctccactaatctgcaaaaagcactttctaaagcactggaaagccgagatgaggtgaaaaccaagtggggtgtttctgacttcatcaaggcctttattaaattccacggtcatgtgtacctgagtaagagcttggaaaagttgagccctcttcgagagaaattggaagaacagtttaagaggctgctattccaaaaagctttcaactctcagcagttagttcatgtcactgtcattaacctgtttcaacttcatcaccttcgtgactttagcaatgaaaccgagcagcacacttatagccaagatgagcagctatgttggacacagttgctggccctctttatgtcttttctcggcatcctgtgcaagtgtcctctacagaatgagtctcaggaggagtcctacaatgcctatcctcttccagcagtcaaggtctccatggactggctaagactcagacccagggtctttcaggaggcagtggtggatgaaagacagtacatttggccctggttgatttctcttctgaatagtttccatccccatgaagaggacctctcaagtattagtgcgacaccacttccagaggagtttgaattacaaggatttttggcattgagaccttctttcaggaacttggatttttccaaaggtcaccagggtattacaggggacaaagaaggccagcaacgacgaatacgacagcaacgcttgatctctataggcaaatggattgctgataatcagccaaggctgattcagtgtgaaaatgaggtagggaaattgttgtttatcacagaaatcccagaattaatactggaagaccccagtgaagccaaagagaacctcattctgcaagaaacatctgtgatagagtcgctggctgcagatgggagcccagggctaaaatcagtgctatctacaagccgaaatttaagcaacaactgtgacacaggagagaagccagtggttaccttcaaagaaaacattaagacacgagaagtgaacagagaccaaggaagaagttttcctcccaaagaggtaaaatcccagacagaactaagaaagactccagtgtctgaagccagaaaaacacctgtaactcaaaccccaactcaagcaagtaactcccagttcatccccattcatcaccctggagccttccctcctcttcccagcaggccagggtttccgcccccaacatatgttatccccccgcctgtggcattttctatgggctcaggttacaccttcccagctggtgtttctgtcccaggaacctttcttcagcctacagctcactctccagcaggaaaccaggtgcaagctgggaaacagtcccacattccttacagccagcaacggccctctggaccagggccaatgaaccagggacctcaacaatcacagccaccttcccagcaaccccttacatctttaccagctcagccaacagcacagtctacaagccagctgcaggttcaagctctaactcagcaacaacaatcccctacaaaagctgtgccggctttggggaaaagcccgcctcaccactctggattccagcagtatcaacaggcagatgcctccaaacagctgtggaatccccctcaggttcaaggcccattagggaaaattatgcctgtgaaacagccctactaccttcagacccaagaccccataaaactgtttgagccgtcattgcaacctcctgtaatgcagcagcagcctctagaaaaaaaaatgaagccttttcccatggagccatataaccataatccctcagaagtcaaggtcccagaattctactgggattcttcctacagcatggctgataacagatctgtaatggcacagcaagcaaacatagaccgcaggggcaaacggtcaccaggaatcttccgtccagagcaggatcctgtacccagaatgccgtttgaggaccccaagagctcccctctgcttcctccggacctgttaaagagtctggctgccttggaggaagaggaagagctgattttttctaacactcctgatctttacccggctctgctggggcctctcgcctctcttcctggacgaagcctttttaaatccttattggagaagccctcagagctcatgtcacattcatcctctttcctgtccctcaccggattctctctcaatcaggaaagatacccaaataatagtatgttcaatgaggtatatgggaaaaacctgacatccagctccaaagcagaactcagtccctcaatggccccccaggaaacatctctgtattccctttttgaagggactccgtggtctccatcacttcctgccagttcagatcattcaacaccagccagccagtctcctcattcctctaacccaagcagcctacccagctctcctccaacacacaaccataattctgttccattctccaattttggacccattgggactccagataacagggatagaaggactgcagatcggtggaaaactgataagccagccatgggtgggtttggcattgattatctctcagcaacgtcatcctctgagagcagttggcatcaggccagcactccgagtggcacctggacaggccatggcccttccatggaggattcctctgctgtcctcatggaaagcctaaagaagcaacagcatggggtccagcagttggggcccaaaagacagtctgaagaggaaggaagcagcagtatctgcgtagcccacagagggcccaggcccctgcccagctgcagtctcccagcctccactttcagagtgaaattcaaggcagcacggacatgtgcccatcaggcacagaagaaaacacgacgtcgtccattttggaagagacgaaagaaaggaaaataa
Sequence Length
3537
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
127,854 Da
NCBI Official Full Name
Homo sapiens Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), mRNA
NCBI Official Synonym Full Names
SMG7, nonsense mediated mRNA decay factor
NCBI Official Symbol
SMG7
NCBI Official Synonym Symbols
EST1C; SGA56M; C1orf16
NCBI Protein Information
protein SMG7
UniProt Protein Name
Protein SMG7
Protein Family
UniProt Gene Name
SMG7
UniProt Synonym Gene Names
C1orf16; EST1C; KIAA0250; hSMG-7
UniProt Entry Name
SMG7_HUMAN
NCBI Description
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Uniprot Description
SMG7: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; nucleus; telomerase holoenzyme complex
Molecular Function: protein binding; protein phosphatase 2A binding; ribonuclease activity; ribonucleoprotein binding; telomeric DNA binding
Biological Process: mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; regulation of dephosphorylation; regulation of RNA stability; telomere maintenance via telomerase
Research Articles on SMG7
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Product Notes
The SMG7 smg7 (Catalog #AAA1273803) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagcctgc agagcgcgca gtacctccgg caggcagaag tcctgaaggc tgacatgaca gattctaagc tgggtccagc tgaagtctgg acatccaggc aggctctgca ggacctgtac cagaaaatgc tagttaccga tttggaatac gctttagaca agaaagtaga acaggatctc tggaatcacg cctttaagaa tcagatcaca acactacaag gccaggcaaa gaatcgagca aatccgaatc ggagtgaagt tcaggcaaac ctttctctgt tcctagaggc agctagtggc ttctatactc agttattaca agaactgtgt acagtattta atgtagattt accatgccgt gtgaagtctt cccaattggg aattatcagc aataaacaga cgcataccag cgccatagtg aagccacagt ctagctcctg ttcctatatc tgccagcact gcctcgtcca ccttggagac attgctcgat acagaaacca gaccagccag gcagagtcct actataggca tgcagctcag cttgtcccct ccaatggtca gccttataat cagttggcta tcttagcttc ttccaaagga gaccatctga ccacaatttt ctactactgc agaagcattg ctgtgaagtt ccctttccca gctgcctcca ctaatctgca aaaagcactt tctaaagcac tggaaagccg agatgaggtg aaaaccaagt ggggtgtttc tgacttcatc aaggccttta ttaaattcca cggtcatgtg tacctgagta agagcttgga aaagttgagc cctcttcgag agaaattgga agaacagttt aagaggctgc tattccaaaa agctttcaac tctcagcagt tagttcatgt cactgtcatt aacctgtttc aacttcatca ccttcgtgac tttagcaatg aaaccgagca gcacacttat agccaagatg agcagctatg ttggacacag ttgctggccc tctttatgtc ttttctcggc atcctgtgca agtgtcctct acagaatgag tctcaggagg agtcctacaa tgcctatcct cttccagcag tcaaggtctc catggactgg ctaagactca gacccagggt ctttcaggag gcagtggtgg atgaaagaca gtacatttgg ccctggttga tttctcttct gaatagtttc catccccatg aagaggacct ctcaagtatt agtgcgacac cacttccaga ggagtttgaa ttacaaggat ttttggcatt gagaccttct ttcaggaact tggatttttc caaaggtcac cagggtatta caggggacaa agaaggccag caacgacgaa tacgacagca acgcttgatc tctataggca aatggattgc tgataatcag ccaaggctga ttcagtgtga aaatgaggta gggaaattgt tgtttatcac agaaatccca gaattaatac tggaagaccc cagtgaagcc aaagagaacc tcattctgca agaaacatct gtgatagagt cgctggctgc agatgggagc ccagggctaa aatcagtgct atctacaagc cgaaatttaa gcaacaactg tgacacagga gagaagccag tggttacctt caaagaaaac attaagacac gagaagtgaa cagagaccaa ggaagaagtt ttcctcccaa agaggtaaaa tcccagacag aactaagaaa gactccagtg tctgaagcca gaaaaacacc tgtaactcaa accccaactc aagcaagtaa ctcccagttc atccccattc atcaccctgg agccttccct cctcttccca gcaggccagg gtttccgccc ccaacatatg ttatcccccc gcctgtggca ttttctatgg gctcaggtta caccttccca gctggtgttt ctgtcccagg aacctttctt cagcctacag ctcactctcc agcaggaaac caggtgcaag ctgggaaaca gtcccacatt ccttacagcc agcaacggcc ctctggacca gggccaatga accagggacc tcaacaatca cagccacctt cccagcaacc ccttacatct ttaccagctc agccaacagc acagtctaca agccagctgc aggttcaagc tctaactcag caacaacaat cccctacaaa agctgtgccg gctttgggga aaagcccgcc tcaccactct ggattccagc agtatcaaca ggcagatgcc tccaaacagc tgtggaatcc ccctcaggtt caaggcccat tagggaaaat tatgcctgtg aaacagccct actaccttca gacccaagac cccataaaac tgtttgagcc gtcattgcaa cctcctgtaa tgcagcagca gcctctagaa aaaaaaatga agccttttcc catggagcca tataaccata atccctcaga agtcaaggtc ccagaattct actgggattc ttcctacagc atggctgata acagatctgt aatggcacag caagcaaaca tagaccgcag gggcaaacgg tcaccaggaa tcttccgtcc agagcaggat cctgtaccca gaatgccgtt tgaggacccc aagagctccc ctctgcttcc tccggacctg ttaaagagtc tggctgcctt ggaggaagag gaagagctga ttttttctaa cactcctgat ctttacccgg ctctgctggg gcctctcgcc tctcttcctg gacgaagcct ttttaaatcc ttattggaga agccctcaga gctcatgtca cattcatcct ctttcctgtc cctcaccgga ttctctctca atcaggaaag atacccaaat aatagtatgt tcaatgaggt atatgggaaa aacctgacat ccagctccaa agcagaactc agtccctcaa tggcccccca ggaaacatct ctgtattccc tttttgaagg gactccgtgg tctccatcac ttcctgccag ttcagatcat tcaacaccag ccagccagtc tcctcattcc tctaacccaa gcagcctacc cagctctcct ccaacacaca accataattc tgttccattc tccaattttg gacccattgg gactccagat aacagggata gaaggactgc agatcggtgg aaaactgata agccagccat gggtgggttt ggcattgatt atctctcagc aacgtcatcc tctgagagca gttggcatca ggccagcact ccgagtggca cctggacagg ccatggccct tccatggagg attcctctgc tgtcctcatg gaaagcctaa agaagcaaca gcatggggtc cagcagttgg ggcccaaaag acagtctgaa gaggaaggaa gcagcagtat ctgcgtagcc cacagagggc ccaggcccct gcccagctgc agtctcccag cctccacttt cagagtgaaa ttcaaggcag cacggacatg tgcccatcag gcacagaaga aaacacgacg tcgtccattt tggaagagac gaaagaaagg aaaataa. It is sometimes possible for the material contained within the vial of "SMG7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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