SLC6A5 cdna clone
SLC6A5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Description
SLC6A5: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. Defects in SLC6A5 are the cause of hyperekplexia type 3 (HKPX3). HKPX3 is a neurologic disorder characterized by neonatal hypertonia, an exaggerated startle response to tactile or acoustic stimuli, and life- threatening neonatal apnea episodes. Notably, in some cases, symptoms resolved in the first year of life. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: glycine:sodium symporter activity
Biological Process: synaptic transmission; synaptic transmission, glycinergic; transport
Disease: Hyperekplexia 3
Research Articles on SLC6A5
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Product Notes
The SLC6A5 slc6a5 (Catalog #AAA1276859) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGATTGCA GTGCTCCCAA GGAAATGAAT AAACTGCCAG CCAACAGCCC GGAGGCGGCG GCGGCGCAGG GCCACCCGGA TGGCCCATGC GCTCCCAGGA CGAGCCCGGA GCAGGAGCTT CCCGCGGCTG CCGCCCCGCC GCCGCCACGT GTGCCCAGGT CCGCTTCCAC CGGCGCCCAA ACTTTCCAGT CAGCGGACGC GCGAGCCTGC GAGGCTGAGC GGCCAGGAGT GGGGTCTTGC AAACTCAGTA GCCCGCGGGC GCAGGCGGCC TCTGCAGCTC TGCGGGACTT GAGAGAGGCG CAAGGCGCGC AGGCCTCGCC CCCTCCCGGG AGCTCCGGGC CCGGCAACGC GTTGCACTGT AAGATCCCTT CTCTGCGAGG CCCGGAGGGG GATGCGAACG TGAGTGTGGG CAAGGGCACC CTGGAGCGGA ACAATACCCC TGTTGTGGGC TGGGTGAACA TGAGCCAGAG CACCGTGGTG CTGGGCACGG ATGGAATCAC GTCCGTGCTC CCGGGCAGCG TGGCCACCGT TGCCACCCAG GAGGACGAGC AAGGGGATGA GAATAAGGCC CGAGGGAACT GGTCCAGCAA ACTGGACTTC ATCCTGTCCA TGGTGGGGTA CGCAGTGGGG CTGGGCAATG TCTGGAGGTT TCCCTACCTG GCCTTCCAGA ACGGGGGAGG TGCTTTCCTC ATCCCTTACC TGATGATGCT GGCTCTGGCT GGATTACCCA TCTTCTTCTT GGAGGTGTCG CTGGGCCAGT TTGCCAGCCA GGGACCAGTG TCTGTGTGGA AGGCCATCCC AGCTCTACAA GGCTGTGGCA TCGCGATGCT GATCATCTCT GTCCTAATAG CCATATACTA CAATGTGATT ATTTGCTATA CACTTTTCTA CCTGTTTGCC TCCTTTGTGT CTGTACTACC CTGGGGCTCC TGCAACAACC CTTGGAATAC ACCAGAATGC AAAGATAAAA CCAAACTTTT ATTAGATTCC TGTGTTATCA GTGACCATCC CAAAATACAG ATCAAGAACT CGACTTTCTG CATGACCGCT TATCCCAACG TGACAATGGT TAATTTCACC AGCCAGGCCA ATAAGACATT TGTCAGTGGA AGTGAAGAGT ACTTCAAGTA CTTTGTGCTG AAGATTTCTG CAGGGATTGA ATATCCTGGC GAGATCAGGT GGCCACTAGC TCTCTGCCTC TTCCTGGCTT GGGTCATTGT GTATGCATCG TTGGCTAAAG GAATCAAGAC TTCAGGAAAA GTGGTGTACT TCACGGCCAC GTTCCCGTAT GTCGTACTCG TGATCCTCCT CATCCGAGGA GTCACCCTGC CTGGAGCTGG AGCTGGGATC TGGTACTTCA TCACACCCAA GTGGGAGAAA CTCACGGATG CCACGGTGTG GAAAGATGCT GCCACTCAGA TTTTCTTCTC TTTATCTGCT GCATGGGGAG GCCTGATCAC TCTCTCTTCT TACAACAAAT TCCACAACAA CTGCTACAGG GACACTCTAA TTGTCACCTG CACCAACAGT GCCACAAGCA TCTTTGCCGG CTTCGTCATC TTCTCCGTTA TCGGCTTCAT GGCCAATGAA CGCAAAGTCA ACATTGAGAA TGTGGCAGAC CAAGGGCCAG GCATTGCATT TGTGGTTTAC CCGGAAGCCT TAACCAGGCT GCCTCTCTCT CCGTTCTGGG CCATCATCTT TTTCCTGATG CTCCTCACTC TTGGACTTGA CACTATGTTT GCCACCATCG AGACCATAGT GACCTCCATC TCAGACGAGT TTCCCAAGTA CCTACGCACA CACAAGCCAG TGTTTACTCT GGGCTGCTGC ATTTGTTTCT TCATCATGGG TTTTCCAATG ATCACTCAGG GTGGAATTTA CATGTTTCAG CTTGTGGACA CCTATGCTGC CTCCTATGCC CTTGTCATCA TTGCCATTTT TGAGCTCGTG GGGATCTCTT ATGTGTATGG CTTGCAAAGA TTCTGTGAAG ATATAGAGAT GATGATTGGA TTCCAGCCTA ACATCTTCTG GAAAGTCTGC TGGGCATTTG TAACCCCAAC CATTTTAACC TTTATCCTTT GCTTCAGCTT TTACCAGTGG GAACCCATGA CCTATGGCTC TTACCGCTAT CCTAACTGGT CCATGGTGCT CGGATGGCTA ATGCTCGCCT GTTCCGTCAT CTGGATCCCA ATTATGTTTG TGATAAAAAT GCATCTGGCC CCTGGAAGAT TTATTGAGAG GCTGAAGTTG GTGTGCTCGC CACAGCCGGA CTGGGGCCCA TTCTTAGCTC AACACCGCGG GGAGCGTTAC AAGAACATGA TCGACCCCTT GGGAACCTCT TCCTTGGGAC TCAAACTGCC AGTGAAGGAT TTGGAACTGG GCACTCAGTG CTAG. It is sometimes possible for the material contained within the vial of "SLC6A5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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