SLC22A12 cdna clone
SLC22A12 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Description
SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: apical plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: inorganic anion exchanger activity; PDZ domain binding; sodium-independent organic anion transmembrane transporter activity; urate transmembrane transporter activity
Biological Process: response to drug; sodium-independent organic anion transport; urate metabolic process; urate transport
Disease: Hypouricemia, Renal, 1
Research Articles on SLC22A12
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Product Notes
The SLC22A12 slc22a12 (Catalog #AAA1268619) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcatttt ctgaactcct ggacctcgtg ggtggcctgg gcaggttcca ggttctccag acgatggctc tgatggtctc catcatgtgg ctgtgtaccc agagcatgct ggagaacttc tcggccgccg tgcccagcca ccgctgctgg gcacccctcc tggacaacag cacggctcag gccagcatcc tagggagctt gagtcctgag gccctcctgg ctatttccat cccgccgggc cccaaccaga ggccccatca gtgccgccgc ttccgccagc cacagtggca gctcttggac cccaatgcca cggccaccag ctggagcgag gccgacacgg agccgtgtgt ggatggctgg gtctatgacc gcagcatctt cacctccaca atcgtggcca agtggaacct cgtgtgtgac tctcacgctc tgaagcccat ggcccagtcc atctacctgg ctgggattct ggtgggagct gctgcgtgcg gccctgcctc agacaggttt gggcgcaggc tggtgctaac ctggagctac cttcagatgg ctgtgatggg tacggcagct gccttcgccc ctgccttccc cgtgtactgc ctgttccgct tcctgttggc ctttgccgtg gcaggcgtca tgatgaacac gggcactctc ctgatggagt ggacggcggc acgggcccga cccttggtga tgaccttgaa ctctctgggc ttcagcttcg gccatggcct gacagctgca gtggcctacg gtgtgcggga ctggacactg ctgcagctgg tggtctcggt ccccttcttc ctctgctttt tgtactcctg gtggctggca gagtcggcac gatggctcct caccacaggc aggctggatt ggggcctgca ggagctgtgg agggtggctg ccatcaacgg aaagggggca gtgcaggaca ccctgacccc tgaggtcttg ctttcagcca tgcgggagga gctgagcatg ggccagcctc ctgccagcct gggcaccctg ctccgcatgc ccggactgcg cttccggacc tgtatctcca cgttgtgctg gttcgccttt ggcttcacct tcttcggcct ggccctggac ctgcaggccc tgggcagcaa catcttcctg ctccaaatgt tcattggtgt cgtggacatc ccagccaaga tgggcgccct gctgctgctg agccacctgg gccgccgccc cacgctggcc gcatccctgt tgctggcggg gctctgcatt ctggccaaca cgctggtgcc ccacgaaatg ggggctctgc gctcagcctt ggccgtgctg gggctgggcg gggtgggggc tgccttcacc tgcatcacca tctacagcag cgagctcttc cccactgtgc tcaggatgac ggcagtgggc ttgggccaga tggcagcccg tggaggagcc atcctggggc ctctggtccg gctgctgggt gtccatggcc cctggctgcc cttgctggtg tatgggacgg tgccagtgct gagtggcctg gccgcactgc ttctgcccga gacccagagc ttgccgctgc ccgacaccat ccaagatgtg cagaaccagg cagtaaagaa ggcaacacat ggcacgctgg ggaactctgt cctaaaatcc acacagtttt ag. It is sometimes possible for the material contained within the vial of "SLC22A12, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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