Western Blot (WB)
(PC-13 cells were subjected to SDS PAGE followed by western blot with MBS7605518 (URAT1 antibody) at dilution of 1:600)
Rabbit URAT1 Polyclonal Antibody | anti-URAT1 antibody
URAT1 Rabbit Polyclonal
Purification: Immunogen affinity purified
Purification: Immunogen affinity purified
Western Blot (WB)
(PC-13 cells were subjected to SDS PAGE followed by western blot with MBS7605518 (URAT1 antibody) at dilution of 1:600)
Western Blot (WB)
(PC-13 cells were subjected to SDS PAGE followed by western blot with MBS7605518 (URAT1 antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Description
SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: apical plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: inorganic anion exchanger activity; PDZ domain binding; sodium-independent organic anion transmembrane transporter activity; urate transmembrane transporter activity
Biological Process: cellular homeostasis; response to drug; sodium-independent organic anion transport; urate metabolic process; urate transport
Disease: Hypouricemia, Renal, 1
Research Articles on URAT1
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Product Notes
The URAT1 slc22a12 (Catalog #AAA7605518) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The URAT1 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's URAT1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). WB : 1:200 - 1:2000. Researchers should empirically determine the suitability of the URAT1 slc22a12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "URAT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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