SETD7 cdna clone
SETD7 cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
SETD7: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily.
Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 4q28
Cellular Component: nucleolus; nucleoplasm
Molecular Function: histone-lysine N-methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity
Biological Process: peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; response to DNA damage stimulus
Research Articles on SETD7
Similar Products
Product Notes
The SETD7 setd7 (Catalog #AAA1265703) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGATAGCG ACGACGAGAT GGTGGAGGAG GCGGTGGAAG GGCACCTGGA CGATGACGGA TTACCGCACG GGTTCTGCAC AGTCACCTAC TCCTCCACAG ACAGATTTGA GGGGAACTTT GTTCACGGAG AAAAGAACGG ACGGGGGAAG TTCTTCTTCT TTGATGGCAG CACCCTGGAG GGGTATTATG TGGATGATGC CTTGCAGGGC CAGGGAGTTT ACACTTACGA AGATGGGGGA GTTCTCCAGG GCACGTATGT AGACGGAGAG CTGAACGGTC CAGCCCAGGA ATATGACACA GATGGGAGAC TGATCTTCAA GGGGCAGTAT AAAGATAACA TTCGTCATGG AGTGTGCTGG ATATATTACC CAGATGGAGG AAGCCTTGTA GGAGAAGTAA ATGAAGATGG GGAGATGACT GGAGAGAAGA TAGCCTATGT GTACCCTGAT GAGAGGACCG CACTTTATGG GAAATTTATT GATGGAGAGA TGATAGAAGG CAAACTGGCT ACCCTTATGT CCACTGAAGA AGGGAGGCCT CACTTTGAAC TGATGCCTGG AAATTCAGTG TACCACTTTG ATAAGTCGAC TTCATCTTGC ATTTCTACCA ATGCTCTTCT TCCAGATCCT TATGAATCAG AAAGGGTTTA TGTTGCTGAA TCTCTTATTT CCAGTGCTGG AGAAGGACTT TTTTCAAAGG TAGCTGTGGG ACCTAATACT GTTATGTCTT TTTATAATGG AGTTCGAATT ACACACCAAG AGGTTGACAG CAGGGACTGG GCCCTTAATG GGAACACCCT CTCCCTTGAT GAAGAAACGG TCATTGATGT GCCTGAGCCC TATAACCACG TATCCAAGTA CTGTGCCTCC TTGGGACACA AGGCAAATCA CTCCTTCACT CCAAACTGCA TCTACGATAT GTTTGTCCAC CCCCGTTTTG GGCCCATCAA ATGCATCCGC ACCCTGAGAG CAGTGGAGGC CGATGAAGAG CTCACCGTTG CCTATGGCTA TGACCACAGC CCCCCCGGGA AGAGTGGGCC TGAAGCCCCT GAGTGGTACC AGGTGGAGCT GAAGGCCTTC CAGGCCACCC AGCAAAAGTG A. It is sometimes possible for the material contained within the vial of "SETD7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
