RPL11 cdna clone
RPL11
Translation Sequence: MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF SKARYTVRSFGIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS DTGNFGFGIQ EHIDLGIKYDPSIGIYGLDF YVVLGRPGFS IADKKRRTGC IGAKHRISKE EAMRWFQQKY DGIILPGK
NCBI and Uniprot Product Information
NCBI Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
Uniprot Description
RPL11: Binds to 5S ribosomal RNA. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML. Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7). DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L5P family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Motility/polarity/chemotaxis; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 1p36.1-p35
Cellular Component: membrane; cytoplasm; nucleolus; cytosol
Molecular Function: rRNA binding; protein binding; structural constituent of ribosome; RNA binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; viral reproduction; translation; ribosomal large subunit biogenesis and assembly; translational termination; viral infectious cycle; cellular protein metabolic process; translational elongation; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; rRNA processing; protein targeting
Disease: Diamond-blackfan Anemia 7
Research Articles on RPL11
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Product Notes
The RPL11 rpl11 (Catalog #AAA200909) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAATrans lation Sequence: MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC IGAKHRISKE EAMRWFQQKY DGIILPGK. It is sometimes possible for the material contained within the vial of "RPL11, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.
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