RNF5 cdna clone

RNF5 cDNA Clone

Cat. Num. AAA1277511

• Gene Names: RNF5; RMA1; RING5
• Synonyms: RNF5; RNF5 cDNA Clone; RNF5 cdna clone

• Sequence: ATGGCAGCAGCGGAGGAGGAGGACGGGGGCCCCGAAGGGCCAAATCGCGAGCGGGGCGGGGCGGGCGCGACCTTCGAATGTAATATATGTTTGGAGACTGCTCGGGAAGCTGTGGTCAGTGTGTGTGGCCACCTGTACTGTTGGCCATGTCTTCATCAGTGGCTGGAGACACGGCCAGAACGGCAAGAGTGTCCAGTATGTAAAGCTGGGATCAGCAGAGAGAAGGTTGTCCCGCTTTATGGGCGAGGGAGCCAGAAGCCCCAGGATCCCAGATTAAAAACTCCACCCCGCCCCCAGGGCCAGAGACCAGCTCCGGAGAGCAGAGGGGGATTCCAGCCATTTGGTGATACCGGGGGCTTCCACTTCTCATTTGGTGTTGGTGCTTTTCCCTTTGGCTTTTTCACCACCGTCTTCAATGCCCATGAGCCTTTCCGCCGGGGTACAGGTGTGGATCTGGGACAGGGTCACCCGGCCTCCAGCTGGCAGGATTCCCTCTTCCTGTTTCTCGCCATCTTCTTCTTTTTTTGGCTGCTCAGTATTTGA
• Sequence Length: 543

• Vector: pENTR223.1 or pUC
• Clone Sequence Report: Provided with product shipment

NCBI and Uniprot Product Information

• NCBI GI #: 111599521
• NCBI GeneID: 6048
• Molecular Weight: 19,881 Da
• NCBI Official Full Name: Homo sapiens ring finger protein 5, mRNA
• NCBI Official Synonym Full Names: ring finger protein 5
• NCBI Official Symbol: RNF5
• NCBI Official Synonym Symbols: RMA1; RING5
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF5
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF5
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF5
• UniProt Synonym Gene Names: G16; NG2; RMA1; HsRma1
• UniProt Entry Name: RNF5_HUMAN

NCBI Description

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

Uniprot Description

RNF5: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Protein type: Ubiquitin ligase; Membrane protein, integral; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21.3

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: cellular protein catabolic process