RNF138 cdna clone
RNF138 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Description
RNF138: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: nucleus
Molecular Function: protein binding; protein kinase binding; single-stranded DNA binding; ubiquitin conjugating enzyme binding
Biological Process: double-strand break repair via homologous recombination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination
Research Articles on RNF138
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Product Notes
The RNF138 rnf138 (Catalog #AAA1271706) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccgagg acctctctgc ggccacgtcc tacaccgaag atgatttcta ctgccccgtc tgtcaggagg tgctcaaaac gcccgtgcgg accacggcct gtcagcacgt tttctgtaga aaatgtttcc tgactgcaat gagggaaagc ggagcacatt gtcccctatg tcgtggaaat gtgactagaa gagagagagc atgtcctgaa cgggccttag accttgaaaa tataatgagg aagttttctg gtagctgcag atgctgtgca aaacagatta aattctatcg catgagacat cattacaaat cttgtaagaa gtatcaggat gaatatggtg tttcttctat cattccaaac tttcagatct ctcaagattc agtagggaac agcaatagga gtgaaacatc cacatctgat aacacagaaa cttaccaaga gaatacaagt tcttctggtc atcctacttt taagtgtccc ctgtgtcaag aatcaaattt taccagacag cgtttactgg atcactgtaa cagtaatcac ctatttcaga tagttcctgt gacatgtcct atttgtgtgt ctcttccttg gggagatcct agccagatta ccagaaattt cgttagtcat ctaaatcaga gacatcaatt tgattatgga gaatttgtga atcttcagct agatgaagaa acccaatacc aaactgctgt tgaagaatct tttcaagtaa acatctga. It is sometimes possible for the material contained within the vial of "RNF138, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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