RIT1 cdna clone
RIT1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Uniprot Description
RIT1: a small G protein of the Ras family. Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and p38-alpha signaling pathways and in NGF- dependent neuronal differentiation. Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation. Interacts with afadin, the C-terminal domain of RalGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with c-Raf. BRAF and c-RAF association is dependent upon the GTP-bound state. Interacts with RGL3. Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras
Chromosomal Location of Human Ortholog: 1q22
Molecular Function: calmodulin binding; GTP binding; GTPase activity; protein binding
Biological Process: Ras protein signal transduction; signal transduction
Disease: Noonan Syndrome 8
Research Articles on RIT1
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Product Notes
The RIT1 rit1 (Catalog #AAA1277971) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGATTCTG GAACTCGCCC AGTTGGTAGC TGCTGTAGCA GCCCCGCTGG GCTCTCACGG GAGTACAAAC TAGTGATGCT GGGTGCTGGT GGTGTAGGGA AGAGTGCCAT GACCATGCAG TTCATCAGCC ACCGATTCCC AGAAGATCAT GATCCCACCA TTGAAGATGC TTATAAGATC AGGATCCGTA TTGATGATGA GCCTGCCAAT CTGGACATTT TGGATACAGC TGGACAGGCA GAGTTTACAG CCATGCGGGA CCAGTATATG AGGGCAGGAG AAGGGTTTAT CATCTGTTAC TCTATCACGG ATCGTCGAAG TTTCCATGAA GTTCGTGAGT TTAAACAGCT TATTTATCGA GTCCGACGTA CTGACGATAC ACCTGTGGTT CTTGTGGGAA ACAAGTCAGA CCTCAAACAG CTAAGACAGG TCACCAAGGA AGAAGGATTG GCCTTGGCCC GAGAATTCAG CTGTCCCTTT TTTGAGACAT CTGCTGCATA CCGCTACTAT ATTGATGATG TTTTCCATGC CCTTGTACGG GAGATACGTA GGAAAGAAAA GGAGGCAGTA CTGGCCATGG AGAAAAAATC TAAGCCCAAA AACAGTGTAT GGAAGAGGCT AAAATCACCA TTCCGGAAGA AGAAAGATTC AGTAACTTGA. It is sometimes possible for the material contained within the vial of "RIT1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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