NCBI Description
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]
Uniprot Description
RGS11: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasm; plasma membrane; protein complex
Molecular Function: G-protein beta-subunit binding; GTPase activator activity
Biological Process: regulation of G-protein coupled receptor protein signaling pathway
Product Notes
The RGS11 rgs11 (Catalog #
AAA1274070) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCGCCG GCCCCGCGCC GCCCCCCGGC CGCCCCCGGG CGCAGATGCC GCATCTGAGG AAGATGGAGC GGGTGGTCGT GAGCATGCAG GACCCCGACC AGGGCGTGAA GATGCGGAGC CAGCGCCTGC TGGTCACCGT CATTCCCCAC GCGGTGACAG GCAGCGACGT CGTGCAGTGG TTGGCCCAGA AGTTCTGCGT CTCGGAGGAG GAGGCCCTGC ACCTGGGCGC CGTCCTGGTG CAGCATGGCT ACATCTACCC GCTGCGCGAC CCCCGTAGCC TCATGCTCCG GCCAGACGAG ACGCCCTACA GGTTCCAGAC CCCGTACTTC TGGACAAGTA CCCTGAGGCC GGCTGCAGAG CTGGACTATG CCATCTACCT GGCCAAGAAG AACATCCGAA AACGGGGGAC CCTGGTGGAC TATGAGAAGG ACTGCTATGA CCGGCTACAC AAGAAGATCA ACCACGCATG GGACCTGGTG CTGATGCAGG CGAGGGAGCA GCTGAGGGCA GCCAAGCAGC GCAGCAAGGG GGACAGGCTG GTCATTGCGT GCCAGGAGCA GACCTACTGG CTGGTGAACA GGCCCCCGCC CGGGGCCCCC GATGTGCTGG AGCAGGGTCC AGGGCGGGGA TCCTGCGCTG CCAGCCGTGT GCTCATGACC AAGAGTGCAG ATTTCCATAA GCGGGAGATC GAGTACTTCA GGAAAGCGCT GGGCAGGACC CGAGTGAAGT CCTCCGTCTG CCTTGAGGCG TACCTGAGTT TCTGCGGCCA GCGTGGACCC CACGATCCCC TCGTGTCGGG GTGCCTGCCC AGCAATCCCT GGATCTCAGA CAATGACGCC TACTGGGTCA TGAATGCCCC CACGGTGGCT GCCCCCACGA AGCTCCGTGT GGAGAGATGG GGCTTCAGCT TCCGGGAGCT CCTGGAGGAC CCCGTGGGGC GGGCCCACTT CATGGACTTT CTGGGAAAGG AGTTCAGTGG AGAAAACCTC AGCTTCTGGG AGGCATGTGA GGAGCTTCGA TATGGAGCGC AGGCCCAGGT CCCCACCCTG GTGGATGCCG TGTACGAGCA GTTCCTGGCC CCCGGAGCTG CCCACTGGGT CAACATCGAC AGCCGGACCA TGGAGCAGAC CCTGGAGGGG CTGCGCCAGC CCCACCGCTA TGTCCTGGAT GACGCCCAGC TGCACATATA CATGCTCATG AAGAAGGACT CCTACCCAAG GTTCCTGAAG TCTGACATGT ACAAGGCCCT CCTGGCAGAG GCTGGGATCC CGCTGGAGAT GAAGAGACGC GTGTTCCCGT TTACGTGGAG GCCACGGCAC TCGAGCCCCA GCCCTGCACT CCTTCCCACC CCTGTGGAGC CCACAGCGGC TTGTGGCCCT GGGGGTGGAG ATGGGGTGGC CTAG.
It is sometimes possible for the material contained within the vial of
"RGS11, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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