RBMX cdna clone

RBMX

Cat. Num. AAA200931

• Gene Names: RBMX; RNMX; HNRPG; HNRNPG; MRXS11; RBMXP1; RBMXRT; hnRNP-G
• Synonyms: RBMX; hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX; RBMX cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGTTGAAGCAGATCGCCCAGGAAAGCTCTTCATTGGTGGGCTTAATACGGAAACAAATGAGAAAGCTCTTGAAGCAGTATTTGGCAAATATGGACGAATAGTGGAAGTACTCTTGATGAAAGACCGTGAAACCAACAAATCAAGAGGATTTGCTTTTGTCACCTTTGAAAGCCCAGCAGACGCTAAGGATGCAGCCAGAGACATGAATGGAAAGTCATTAGATGGAAAAGCCATCAAGGTGGAACAAGCCACCAAACCATCATTTGAAAGTGGTAGACGTGGACCGCCTCCACCTCCAAGAAGTAGAGGCCCTCCAAGAGGTCTTAGAGGTGGAAGAGGAGGAAGTGGAGGAACCAGGGGACCTCCCTCACGGGGAGGACACATGGATGACGGTGGATATTCCATGAATTTTAACATGAGTTCTTCCAGGGGACCACTCCCAGTAAAAAGAGGACCACCACCAAGAAGTGGGGGTCCTCCTCCTAAGAGATCTGCACCTTCAGGACCAGTTCGCAGTAGCAGTGGAATGGGAGGAAGAGCTCCTGTATCACGTGGAAGAGATAGTTATGGAGGTCCACCTCGAAGGGAACCGCTGCCCTCTCGTAGAGATGTTTATTTGTCCCCAAGAGATGATGGGTATTCTACTAAAGACAGCTATTCAAGCAGAGATTACCCAAGTTCTCGTGATACTAGAGATTATGCACCACCACCACGAGATTATACTTACCGTGATTATGGTCATTCCAGTTCACGTGATGACTATCCATCAAGAGGATATAGCGATAGAGATGGATATGGTCGTGATCGTGACTATTCAGATCATCCAAGTGGAGGTTCCTACAGAGATTCATATGAGAGTTATGGTAACTCACGTAGTGCTCCACCTACACGAGGGCCCCCGCCATCTTATGGTGGAAGCAGTCGCTATGATGATTACAGCAGCTCACGTGACGGATATGGTGGAAGTCGAGACAGTTACTCAAGCAGCCGAAGTGATCTCTACTCAAGTGGTCGTGATCGGGTTGGCAGACAAGAAAGAGGGCTTCCCCCTTCTATGGAAAGGGGGTACCCTCCTCCACGTGATTCCTACAGCAGTTCAAGCCGCGGAGCACCAAGAGGTGGTGGCCGTGGAGGAAGCCGATCTGATAGAGGGGGAGGCAGAAGCAGATACTAG; ; Translation Sequence: MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA DAKDAARDMN GKSLDGKAIK VEQATKPSFE SGRRGPPPPP RSRGPPRGLR GGRGGSGGTR GPPSRGGHMD DGGYSMNFNM SSSRGPLPVK RGPPPRSGGP PPKRSAPSGP VRSSSGMGGR APVSRGRDSY GGPPRREPLP SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD YTYRDYGHSS SRDDYPSRGY SDRDGYGRDR DYSDHPSGGS YRDSYESYGN SRSAPPTRGP PPSYGGSSRY DDYSSSRDGY GGSRDSYSSS RSDLYSSGRD RVGRQERGLP PSMERGYPPP RDSYSSSSRG APRGGGRGGS RSDRGGGRSR Y
• Sequence Length: 391

• Species: Human
• Chromosome Location: Xq26.3
• OMIM Reference Number: 300199
• cDNA Size: 1176bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for RBMX cdna clone

RBMX belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns.

Product Categories/Family for RBMX cdna clone

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 56699409
• NCBI GeneID: 27316
• NCBI Accession #: NP_002130.2
• NCBI GenBank Nucleotide #: NM_002139.3
• UniProt Accession #: P38159
• NCBI Official Full Name: RNA-binding motif protein, X chromosome isoform 1
• NCBI Official Synonym Full Names: RNA binding motif protein X-linked
• NCBI Official Symbol: RBMX
• NCBI Official Synonym Symbols: RNMX; HNRPG; HNRNPG; MRXS11; RBMXP1; RBMXRT; hnRNP-G
• NCBI Protein Information: RNA-binding motif protein, X chromosome
• UniProt Protein Name: RNA-binding motif protein, X chromosome
• Protein Family: RNA-binding motif protein
• UniProt Gene Name: RBMX
• UniProt Synonym Gene Names: HNRPG; RBMXP1; hnRNP G
• UniProt Entry Name: RBMX_HUMAN

NCBI Description

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]

Uniprot Description

RBMX: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; RNA processing; Tumor suppressor; RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: nucleoplasm; extracellular space; membrane; nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; RNA binding; nucleotide binding; chromatin binding

Biological Process: positive regulation of nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; osteoblast differentiation; nuclear mRNA splicing, via spliceosome; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; membrane protein ectodomain proteolysis; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of alternative nuclear mRNA splicing, via spliceosome; protein homooligomerization