RAD1 cdna clone
RAD1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]
Uniprot Description
RAD1: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity. Belongs to the rad1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage; Deoxyribonuclease; Cell cycle regulation; EC 3.1.11.2
Chromosomal Location of Human Ortholog: 5p13.2
Cellular Component: chromosome; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: 3'-5' exonuclease activity; damaged DNA binding; protein binding
Biological Process: DNA damage checkpoint; DNA replication; meiotic recombination checkpoint; response to DNA damage stimulus; substantia nigra development
Research Articles on RAD1
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Product Notes
The RAD1 rad1 (Catalog #AAA1274264) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgccccttc tgacccaaca gatccaagac gaggatgatc agtacagcct tgtggccagc cttgacaacg ttaggaatct ctccactatc ttgaaagcta ttcatttccg agaacatgcc acgtgtttcg caactaaaaa tggtatcaaa gtaacagtgg aaaatgcaaa gtgtgtgcaa gcaaatgctt ttattcaggc tggaatattt caggagttta aagttcagga agagtctgtt acttttcgaa ttaatttaac tgtcctttta gactgtttat ctatttttgg atcaagtcct atgccaggga ctttaactgc acttcgaatg tgttaccaag gttatggtta ccctttgatg ctgttcctgg aagaaggagg agtggtgaca gtctgcaaaa tcaatacaca ggaacctgag gagaccctgg actttgattt ctgcagcacc aatgttatta ataaaattat tctgcagtca gaggggctcc gtgaagcatt ttctgaattg gatatgacga gtgaagtcct acaaattacc atgtctcctg acaagcctta tttcaggtta tctacttttg gaaatgcagg aagttcccac cttgactatc ccaaagattc tgatttgatg gaagcatttc attgtaatca gacccaagtc aacagataca agatttcctt actgaaaccc tctacaaagg cattagtcct atcttgtaag gtatctattc ggacagataa cagaggcttc ctttcattac agtatatgat tagaaatgaa gatggacaaa tatgttttgt ggaatattac tgctgccctg atgaagaagt tcctgaatct gagtcttga. It is sometimes possible for the material contained within the vial of "RAD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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