RACGAP1 cdna clone
RACGAP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]
Uniprot Description
MgcRacGAP: a rac GTPase activating protein. Plays an important role in cytokinesis by regulating cortical movement through RhoA. Phosphorylation by Aurora B apparently induces GAP activity toward RhoA.
Protein type: GAPs; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: cleavage furrow; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; midbody; nucleoplasm; nucleus; spindle midzone
Molecular Function: alpha-tubulin binding; beta-tubulin binding; gamma-tubulin binding; GTPase activator activity; microtubule binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein kinase binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cytokinesis after mitosis; cytokinesis, contractile ring formation; embryonic development; microtubule-based movement; neuroblast proliferation; positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; regulation of small GTPase mediated signal transduction; retrograde vesicle-mediated transport, Golgi to ER; spermatogenesis; spindle midzone assembly involved in mitosis; sulfate transport
Research Articles on RACGAP1
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Product Notes
The RACGAP1 racgap1 (Catalog #AAA1266440) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatacta tgatgctgaa tgtgcggaat ctgtttgagc agcttgtgcg ccgggtggag attctcagtg aaggaaatga agtccaattt atccagttgg cgaaggactt tgaggatttc cgtaaaaagt ggcagaggac tgaccatgag ctggggaaat acaaggatct tttgatgaaa gcagagactg agcgaagtgc tctggatgtt aagctgaagc atgcacgtaa tcaggtggat gtagagatca aacggagaca gagagctgag gctgactgcg aaaagctgga acgacagatt cagctgattc gagagatgct catgtgtgac acatctggca gcattcaact aagcgaggag caaaaatcag ctctggcttt tctcaacaga ggccaaccat ccagcagcaa tgctgggaac aaaagactat caaccattga tgaatctggt tccattttat cagatatcag ctttgacaag actgatgaat cactggattg ggactcttct ttggtgaaga ctttcaaact gaagaagaga gaaaagaggc gctctactag ccgacagttt gttgatggtc cccctggacc tgtaaagaaa actcgttcca ttggctctgc agtagaccag gggaatgaat ccatagttgc aaaaactaca gtgactgttc ccaatgatgg cgggcccatc gaagctgtgt ccactattga gactgtgcca tattggacca ggagccgaag gaaaacaggt actttacaac cttggaacag tgactccacc ctgaacagca ggcagctgga gccaagaact gagacagaca gtgtgggcac gccacagagt aatggaggga tgcgcctgca tgactttgtt tctaagacgg ttattaaacc tgaatcctgt gttccatgtg gaaagcggat aaaatttggc aaattatctc tgaagtgtcg agactgtcgt gtggtctctc atccagaatg tcgggaccgc tgtccccttc cctgcattcc taccctgata ggaacacctg tcaagattgg agagggaatg ctggcagact ttgtgtccca gacttctcca atgatcccct ccattgttgt gcattgtgta aatgagattg agcaaagagg tctgactgag acaggcctgt ataggatctc tggctgtgac cgcacagtaa aagagctgaa agagaaattc ctcagagtga aaactgtacc cctcctcagc aaagtggatg atatccatgc tatctgtagc cttctaaaag actttcttcg aaacctcaaa gaacctcttc tgacctttcg ccttaacaga gcctttatgg aagcagcaga aatcacagat gaagacaaca gcatagctgc catgtaccaa gctgttggtg aactgcccca ggccaacagg gacacattag ctttcctcat gattcacttg cagagagtgg ctcagagtcc acatactaaa atggatgttg ccaatctggc taaagtcttt ggccctacaa tagtggccca tgctgtgccc aatccagacc cagtgacaat gttacaggac atcaagcgtc aacccaaggt ggttgagcgc ctgctttcct tgcctctgga gtattggagt cagttcatga tggtggagca agagaacatt gaccccctac atgtcattga aaactcaaat gccttttcaa caccacagac accagatatt aaagtgagtt tactgggacc tgtgaccact cctgaacatc agcttctcaa gactccttca tctagttccc tgtcacagag agtccgttcc accctcacca agaacactcc tagatttggg agcaaaagca agtctgccac taacctagga cgacaaggca acttttttgc ttctccaatg ctcaagtga. It is sometimes possible for the material contained within the vial of "RACGAP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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