RAB7B cdna clone
RAB7B cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
RAB7B: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: Golgi apparatus; late endosome; lysosome; phagocytic vesicle; trans-Golgi network
Biological Process: activation of NF-kappaB transcription factor; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of toll-like receptor 9 signaling pathway; positive regulation of interleukin-6 production; positive regulation of megakaryocyte differentiation
Research Articles on RAB7B
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Product Notes
The RAB7B rab7b (Catalog #AAA1277506) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagccag cacgggaaca ggggggcagc ctagagcaca agctctatct gtgtccttca gagctcctgg gaaacatgat gcgccctcat gggaatggca ttttgcatat cacacaggct gtcctgggag tcaggcagac tggattgtca cgtgcggtgt gcatgcagca gcttgtgcac tgcagtggac ctgtggacca tttctaa. It is sometimes possible for the material contained within the vial of "RAB7B, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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