PTPRO cdna clone
PTPRO cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
Uniprot Description
PTPRO: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; EC 3.1.3.48; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.3-p13.2|12p13-p12
Cellular Component: neuron projection; growth cone; lamellipodium; integral to plasma membrane; axon; apical plasma membrane; integral to membrane; plasma membrane; dendritic spine; lateral plasma membrane
Molecular Function: Wnt-protein binding; protein binding; protein homodimerization activity; phosphoric monoester hydrolase activity; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: lamellipodium biogenesis; axon guidance; monocyte chemotaxis; regulation of glomerular filtration; negative regulation of glomerular filtration; cell morphogenesis; protein amino acid dephosphorylation; glomerulus development
Disease: Nephrotic Syndrome, Type 6
Research Articles on PTPRO
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Product Notes
The PTPRO ptpro (Catalog #AAA1269792) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggggcacc tgcccacggg gatacacggc gcccgccgcc tcctgcctct gctctggctc tttgtgctgt tcaagaatgc tacagctttc catgtaactg tccaagatga taataacatc gttgtctcat tagaagcttc agacgtcatc agtccagcat ctgtgtatgt tgtgaagata actggtgaat ccaaaaatta tttcttcgaa tttgaggaat tcaacagcac tttgcctcct cctgttattt tcaaggccag ttatcatggc ctttattata taatcactct ggtagtggta aatggaaatg tggtgaccaa gccatccaga tcaatcactg tgttaacaaa acctctacct gtaaccagtg tttccatata tgactataaa ccttctcctg aaacaggagt cctgtttgaa atacattatc cagaaaaata taacgttttc acaagagtga acattagcta ctgggaaggt aaagacttcc ggacaatgct atataaagat ttctttaagg gaaaaacagt atttaatcac tggctgccag gaatgtgtta tagtaatatc acctttcagc tggtatctga ggcaactttt aataaaagta cccttgttga gtacagtggt gtcagtcacg aacccaaaca gcacagaact gccccttatc cacctcaaaa tatttccgtt cgtatcgtaa acttgaacaa aaacaactgg gaagaacaga gtggcaattt cccagaagaa tccttcatga gatcacaaga tacaatagga aaagaaaaac tcttccattt tacagaagaa acccctgaaa ttccctcggg caacatttct tccggttggc ctgattttaa tagcagtgac tatgaaacta cgtctcagcc atattggtgg gacagtgcat ctgcagctcc tgaaagtgaa gatgaatttg tcagcgtact tcccatggaa tacgaaaata acagtacact cagtgagaca gagaagtcaa catcaggctc tttctccttt ttccctgtgc aaatgatatt gacctggtta ccacccaaac cacccactgc ttttgatggg ttccatatcc atattgaacg agaagagaac tttactgaat atttgatggt ggatgaagaa gcacatgaat ttgttgcaga actgaaggaa cctgggaaat ataagttatc tgtgacaacc tttagttcct caggatcttg tgaaactcga aaaagtcagt cagcaaaatc actcagcttt tatatcagtc cttcaggaga gtggattgaa gaactgaccg agaagccgca gcacgtgagt gtccacgttt taagctcaac cactgccttg atgtcctgga catcttccca agagaactac aacagcacca ttgtgtctgt ggtgtcgctg acctgccaga aacaaaagga gagccagagg cttgaaaagc agtactgcac tcaggtgaac tcaagcaaac ctattattga aaatctggtt cctggtgccc agtaccaggt tgtaatatac ctaaggaaag gccctttgat tggaccacct tcagatcctg tgacatttgc tattgttccc acaggaataa aggatttaat gctctatcct ttgggtccta cggccgtggt tctgagctgg accagacctt atttaggcgt gttcagaaaa tacgtggttg aaatgtttta tttcaaccct gctacaatga catcagagtg gaccacctac tatgaaatag cagcaactgt ttccttaact gcatccgtga gaatagctaa tctgctgcca gcatggtact acaacttccg ggttaccatg gtgacgtggg gagatccaga attgagctgc tgtgacagct ctaccatcag cttcataaca gccccagtgg ctccggaaat cacttctgtg gaatatttca acagtctgtt atatatcagt tggacatatg gggatgatac aacggacttg tcccattcta gaatgcttca ctggatggtg gttgcagaag gaaaaaagaa aattaaaaag agtgtaacac gcaatgtcat gactgcaatt ctcagcttgc ctccaggcga catctataac ctctcagtaa ctgcttgtac tgaaagagga agtaatacct ccatgctccg ccttgtcaag ctagaaccag ctccacccaa atcactcttc gcagtgaaca aaacccagac ttcagtgact ttgctgtggg tggaagaggg agtagctgat ttctttgaag ttttctgtca acaagttggc tccagtcaga aaaccaaact tcaggaacca gttgctgttt cttcccatgt cgtgaccatc tccagccttc ttcctgccac tgcctacaat tgtagtgtca ccagctttag ccatgacagc cccagtgtcc ctacgttcat agccgtctca acaatggtta cagagatgaa tcccaatgtg gtagtgatct ccgtgctggc catccttagc acacttttaa ttggactgtt gcttgttacc ctcattattc ttaggaaaaa gcatctgcag atggctaggg agtgtggagc tggtacattt gtcaattttg catccttaga gagggatgga aagcttccat acaactggcg taggagtata tttgctttct taaccctgct accctcatgt ctttggactg attatctttt ggcattttat attaatcctt ggagtaaaaa tggtttaaag aagaggaaac tgacaaaccc ggttcaactg gatgactttg atgcctatat taaggatatg gccaaagact ctgactataa attttctctt cagtttgagg agttgaaatt gattggactg gatatcccac actttgctgc agatcttcca ctgaatcgat gtaaaaaccg ttacacaaac atcctaccat atgacttcag ccgtgtgaga ttagtctcca tgaatgaaga ggaaggtgca gactacatca atgccaacta tattcctgga tacaactcac cccaggagta tattgccacc caggggccac tgcctgaaac cagaaatgac ttctggaaga tggtcctgca acaaaagtct cagattattg tcatgctcac tcagtgtaat gagaaaagga gggtgaaatg tgaccattac tggccattca cggaagaacc tatagcctat ggagacatca ctgtggagat gatttcagag gaagagcagg acgactgggc ctgtagacac ttccggatca actatgctga cgagatgcag gatgtgatgc attttaacta cactgcatgg cctgatcatg gtgtgcccac agcaaatgct gcagaaagta tcctgcagtt tgtacacatg gtccgacagc aagctaccaa gagcaaaggt cccatgatca ttcactgcag tgctggcgtg ggacggacag gaacattcat tgccctggac aggctcttgc agcacattcg ggatcatgag tttgttgaca tcttagggct ggtgtcagaa atgaggtcat accggatgtc tatggtacag acagaggagc agtacatttt tatccatcag tgtgtgcaac tgatgtggat gaagaagaag cagcagttct gcatcagtga tgtcatatac gagaatgtta gcaagtccta g. It is sometimes possible for the material contained within the vial of "PTPRO, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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