PSMD10 cdna clone
PSMD10 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]
Uniprot Description
PSMD10: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: Xq22.3
Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; nucleoplasm; nucleus; proteasome complex; proteasome regulatory particle
Molecular Function: protein binding; transcription factor binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cytoplasmic sequestering of NF-kappaB; inhibition of NF-kappaB transcription factor; MAPKKK cascade; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPKKK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMD10
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Product Notes
The PSMD10 psmd10 (Catalog #AAA1269225) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggaggggt gtgtgtctaa cctaatggtc tgcaacctgg cctacagcgg gaagctggaa gagttgaagg agagtattct ggccgataaa tccctggcta ctagaactga ccaggacagc agaactgcat tgcactgggc atgctcagct ggacatacag aaattgttga atttttgttg caacttggag tgccagtgaa tgataaagac gatgcaggtt ggtctcctct tcatattgcg gcttctgctg gccgggatga gattgtaaaa gcccttctgg gaaaaggtgc tcaagtgaat gctgtcaatc aaaatggctg tactccctta cattatgcag cttcgaaaaa caggcatgag atcgctgtca tgttactgga aggcggggct aatccagatg ctaaggacca ttatgaggct acagcaatgc accgggcagc agccaagggt aacttgaaga tgattcatat ccttctgtac tacaaagcat ccacaaacat ccaagacact gagggtaaca ctcctctaca cttagcctgt gatgaggaga gagtggaaga agcaaaactg ctggtgtccc aaggagcaag tatttacatt gagaataaag aagaaaagac acccctgcaa gtggccaaag gtggcctggg tttaatactc aagagaatgg tggaaggtta a. It is sometimes possible for the material contained within the vial of "PSMD10, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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