PSMC1 cdna clone
PSMC1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
Uniprot Description
RPT2: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family.
Protein type: Proteasome complex; Protease
Chromosomal Location of Human Ortholog: 14q32.11
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus; proteasome complex
Molecular Function: ATPase activity; protein binding; TATA-binding protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ER-associated protein catabolic process; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of transcriptional preinitiation complex assembly; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMC1
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Product Notes
The PSMC1 psmc1 (Catalog #AAA1268178) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggtcaaa gtcagagtgg tggtcatggt cctggaggtg gcaagaagga tgacaaggac aagaaaaaga aatatgaacc tcctgtacca actagagtgg ggaaaaagaa gaagaaaaca aagggaccag atgctgccag caaactgcca ctggtgacac ctcacactca gtgccggtta aaattactga agttagagag aattaaagac tatcttctca tggaggaaga attcattaga aatcaggaac aaatgaaacc attagaagaa aagcaagagg aggaaagatc aaaagtggat gatctgaggg ggaccccgat gtcagtagga accttggaag agattattga tgacaatcgt gccatcgtgt ctacatctgt gggctcagaa cactacgtca gcattctttc atttgtagac aaggatctgc tggaacctgg ctgctcggtc ctgctcaacc acaaggtgca tgccgtgata ggggtgctga tggatgacac ggatcccctg gtcacagtga tgaaggtaga aaaggccccc caggagacct atgcagatat tggggggttg gacaaccaaa ttcaggaaat taaggaatct gtggagcttc ctctcaccca tcctgaatat tatgaagaga tgggtataaa gcctcctaag ggggtcattc tctatggtcc acctggcaca ggtaaaacct tgttagccaa agcagtagca aaccaaacct cagccacttt cttgagagtg gttggctctg aacttattca gaagtaccta ggtgatgggc ccaaactcgt acgggaattg ttccgagttg ctgaagaaca tgcaccgtcc atcgtgttta ttgatgaaat tgacgccatt gggacaaaaa gatatgactc caattctggt ggtgagagag aaattcagcg aacaatgttg gaactgctga accagttgga tggatttgat tctaggggag atgtgaaagt tatcatggcc acaaaccgaa tagaaacttt ggatccagca cttatcagac caggccgcat tgacaggaag attgagttcc ccctgcctga tgaaaagacg aagaagcgca tctttcagat tcacacaagc aggatgacgc tggctgatga tgtaaccctg gacgacctga tcatggctaa agatgacctc tctggtgctg acatcaaggc aatctgtaca gaagctggtc tgatggcctt aagagaacgt agaatgaaag taacaaatga agacttcaaa aaatctaaag aaaatgttct ttataagaaa caggaaggca cccctgaggg gctgtatctc taa. It is sometimes possible for the material contained within the vial of "PSMC1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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