PSMB1 cdna clone
PSMB1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]
Uniprot Description
PSMB1: a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
Protein type: EC 3.4.25.1; Proteasome complex; Cell cycle regulation; Protease
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function: protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMB1
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Product Notes
The PSMB1 psmb1 (Catalog #AAA1274422) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgttgtcct ctacagccat gtattcggct cctggcagag acttggggat ggaaccgcac agagccgcgg gccctttgca gctgcgattt tcgccctacg ttttcaacgg aggtactata ctggcaattg ctggagaaga ttttgcaatt gttgcttctg atactcgatt gagtgaaggg ttttcaattc atacgcggga tagccccaaa tgttacaaat taacagacaa aacagtcatt ggatgcagcg gttttcatgg agactgtctt acgctgacaa agattattga agcaagacta aagatgtata agcattccaa taataaggcc atgactacgg gggcaattgc tgcaatgctg tctacaatcc tgtattcaag gcgcttcttt ccatactatg tttacaacat catcggtgga cttgatgaag aaggaaaggg ggctgtatac agctttgatc cagtagggtc ttaccagaga gactccttca aggctggagg ctcagcaagt gccatgctac agcccctgct tgacaaccag gttggtttta agaacatgca gaatgtggag catgttccgc tgtccttgga cagagccatg cggctggtga aagatgtctt catttctgcg gctgagagag atgtgtacac tggggacgca ctccggatct gcatagtgac caaagagggc atcagggagg aaactgtttc cttaaggaag gactga. It is sometimes possible for the material contained within the vial of "PSMB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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