PSMA5 cdna clone
PSMA5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Description
PSMA5: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Up-regulated in colon cancer cell lines. Up-regulated in fetal Down syndrome (DS) brain. May be the target of the transcriptional activator NFE2L2. Expressed in fetal brain. Belongs to the peptidase T1A family.
Protein type: Protease; EC 3.4.25.1; Proteasome complex
Chromosomal Location of Human Ortholog: 1p13
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function: protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMA5
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Product Notes
The PSMA5 psma5 (Catalog #AAA1275679) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTTTCTTA CCCGGTCTGA GTACGACAGG GGCGTGAATA CTTTTTCTCC CGAAGGAAGA TTATTTCAAG TGGAATATGC CATTGAGGCT ATCAAGCTTG GTTCTACAGC CATTGGGATC CAGACATCAG AGGGTGTGTG CCTAGCTGTG GAGAAGAGAA TTACTTCCCC ACTGATGGAG CCCAGCAGCA TTGAGAAAAT TGTAGAGATT GATGCTCACA TAGGTTGTGC CATGAGTGGG CTAATTGCTG ATGCTAAGAC CTTAATTGAT AAAGCCAGAG TGGAGACACA GAACCACTGG TTCACCTACA ATGAGACAAT GACAGTGGAG AGTGTGACCC AAGCTGTGTC CAATCTGGCT TTGCAGTTTG GAGAAGAAGA TGCAGATCCA GGTGCCATGT CTCGTCCCTT TGGAGTAGCA TTATTATTTG GAGGAGTTGA TGAGAAAGGA CCCCAGCTGT TTCATATGGA CCCATCTGGG ACCTTTGTAC AGTGTGATGC TCGAGCAATT GGCTCTGCTT CAGAGGGTGC CCAGAGCTCC TTGCAAGAAG TTTACCACAA GTCTATGACT TTGAAAGAAG CCATCAAGTC TTCACTCATC ATCCTCAAAC AAGTAATGGA GGAGAAGCTG AATGCAACAA ACATTGAGCT AGCCACAGTG CAGCCTGGCC AGAATTTCCA CATGTTCACA AAGGAAGAAC TTGAAGAGGT TATCAAGGAC ATTTAA. It is sometimes possible for the material contained within the vial of "PSMA5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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