PSMA1 cdna clone
PSMA1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Uniprot Description
PSMA1: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome. Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells. Belongs to the peptidase T1A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.25.1; Proteasome complex; Protease
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component: centrosome; cytosol; nucleoplasm; nucleus; polysome; proteasome complex; proteasome core complex
Molecular Function: protein binding; RNA binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMA1
Similar Products
Product Notes
The PSMA1 psma1 (Catalog #AAA1278809) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtttcgaa atcagtatga caatgatgtc actgtttgga gcccccaggg caggattcat caaattgaat atgcaatgga agctgttaaa caaggttcag ccacagttgg tctgaaatca aaaactcatg cagttttggt tgcattgaaa agggcgcaat cagagcttgc agctcatcag aaaaaaattc tccatgttga caaccatatt ggtatctcaa ttgcggggct tactgctgat gctagactgt tatgtaattt tatgcgtcag gagtgtttgg attccagatt tgtattcgat agaccactgc ctgtgtctcg tcttgtatct ctaattggaa gcaagaccca gataccaaca caacgatatg gccggagacc atatggtgtt ggtctcctta ttgctggtta tgatgatatg ggccctcaca ttttccaaac ctgtccatct gctaactatt ttgactgcag agccatgtcc attggagccc gttcccaatc agctcgtact tacttggaga gacatatgtc tgaatttatg gagtgtaatt taaatgaact agttaaacat ggtctgcgtg ccttaagaga gacgcttcct gcagaacagg acctgactac aaagaatgtt tccattggaa ttgttggtaa agacttggag tttacaatct atgatgatga tgatgtgtct ccattcctgg aaggtcttga agaaagacca cagagaaagg cacagcctgc tcaacctgct gatgaacctg cagaaaaggc tgatgaacca atggaacatt aa. It is sometimes possible for the material contained within the vial of "PSMA1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
