PRUNE2 cdna clone
PRUNE2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Description
PRUNE2: May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. Belongs to the PPase class C family. Prune subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 9q21.2
Biological Process: apoptosis
Research Articles on PRUNE2
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Product Notes
The PRUNE2 prune2 (Catalog #AAA1274324) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggacatcc cctttgaaga gggcgtgctg agtcccagtg ctgcagacat gaggcctgaa cctcctaatt ctctggatct taatgacact catcctcgga gaatcaagct cacagcccca aatatcaatc tttctctgga ccaaagtgaa ggatctattc tctctgatga taacttggac agtcctgatg aaattgacat caatgtggat gaacttgata cccccgatga agcagattct tttgagtaca ctggccatga agatcccaca gccaacaaag attctggcca agagtcagag tctattccag aatatacggc cgaagaggaa cgggaggaca accggctttg gaggacagtg gtcattggag aacaagagca gcgcattgac atgaaggtca tcgagcccta caggagagtc atttctcacg gaggatacta tggggacggt ctaaatgcca tcattgtgtt tgccgcctgt tttctgccag acagcagtcg ggcggattac cactatgtca tggaaaatct tttcctatat gtaataagta ctttcacact acagccgcag agctga. It is sometimes possible for the material contained within the vial of "PRUNE2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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